Patents by Inventor Antonio Ferrante
Antonio Ferrante has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8268635Abstract: The present invention relates to a method of selectively modulating a signalling pathway of interest controlled by a cell receptor involved in signalling through multiple pathways. The method includes exposing the receptor to an agent that modulates signalling by the receptor through the signalling pathway of interest and does not substantially modulate signalling through one or more other signalling pathways controlled by the receptor.Type: GrantFiled: May 18, 2007Date of Patent: September 18, 2012Inventors: Antonio Ferrante, Charles S. T. Hii
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Publication number: 20100104546Abstract: The present invention relates to a method of inhibiting antigen-dependent proliferation of T-cells in a subject without substantially inhibiting mitogen-dependent proliferation of T-cells in the subject. The method includes administering to the subject an effective amount of a polyunsaturated fatty acid, or a salt or derivative of a polyunsaturated fatty acid.Type: ApplicationFiled: February 5, 2008Publication date: April 29, 2010Applicant: CHILDREN, YOUTH AND WOMEN'S HEALTH SERVICEInventors: Antonio Ferrante, Nick Gorgani, Charles S.T. Hii
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Publication number: 20090291899Abstract: The present invention relates to a method of selectively modulating a signalling pathway of interest controlled by a cell receptor involved in signalling through multiple signalling pathways The method includes exposing the receptor to an agent that modulates signalling by the receptor through the signalling pathway of interest and does not substantially modulate signalling through one or more other signalling pathways controlled by the receptor.Type: ApplicationFiled: May 18, 2007Publication date: November 26, 2009Inventors: Antonio Ferrante, Charles S.T. Hii
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Publication number: 20090215895Abstract: The present invention relates generally to compounds comprising a hydrocarbon chain portion and more particular to compounds comprising chemical derivatizations of the hydrocarbon chain which are useful therapeutic and prophylactic molecules. The present invention further provides compounds where the hydrocarbon chain portion is a carrier molecule for functional groups, moieties or agents. The compounds of the present invention are particularly useful in the treatment and prophylaxis of a range of conditions including cancers, protein kinase c(PKC)- or NFkB-related- or -associated conditions, cardiovascular conditions, pain, inflammatory conditions, vascular or immunological conditions such as diabetes, neurological conditions and infection by a range of viruses or prokaryotic or eukaryotic organisms. The present invention further provides pharmaceutical compositions and methods of medical treatment.Type: ApplicationFiled: January 28, 2005Publication date: August 27, 2009Applicant: PEPLIN BIOLIPIDS PTY LTDInventors: Antonio Ferrante, Deborah Ann Rathjen
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Publication number: 20050222253Abstract: The present invention relates to pharmaceutical compositions comprising, as an anticancer agent: (a) one or more compounds having the formula NO2-A-B, wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 double bonds, and B is (CH2)m(COOH)n in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or a derivative thereof in which the hydrocarbon chain has one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy; (b) one or more compounds selected from polyunsaturated fatty acids (PUFA's) having a 16 to 26 carbon atom chain and 3 to 6 double bonds, and wherein the PUFA is covalently coupled at the carboxylic acid group to an amino acid selected from glycine and aspartic acid; (c) one or more compounds selected from unsaturated fatty acids having an 18 to 25 carbon atom chain and 1 to 6 double bonds and wherein the fatty acid has one or two ?-oxa, ?-oxa, ?-thia, ?-thia substitutions; or (d) one or more compounds having formulaType: ApplicationFiled: May 19, 2005Publication date: October 6, 2005Inventors: Antonio Ferrante, J. Easton, S.T. Hii
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Publication number: 20050176817Abstract: The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A? is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B? is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.Type: ApplicationFiled: March 4, 2005Publication date: August 11, 2005Inventors: Antonio Ferrante, Christopher Easton, Ling Xia
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Publication number: 20050176815Abstract: The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A? is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B? is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.Type: ApplicationFiled: March 4, 2005Publication date: August 11, 2005Inventors: Antonio Ferrante, Christopher Easton, Ling Xia
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Publication number: 20050176816Abstract: The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A? is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B? is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.Type: ApplicationFiled: March 4, 2005Publication date: August 11, 2005Inventors: Antonio Ferrante, Christopher Easton, Ling Xia
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Patent number: 6924309Abstract: The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A? is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B? is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.Type: GrantFiled: March 18, 2002Date of Patent: August 2, 2005Assignees: Children, Youth and Women's Health Service Incorporated, Peptech LimitedInventors: Antonio Ferrante, Christopher J. Easton, Ling Xia
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Publication number: 20050123479Abstract: The present invention provides a novel scientific approach to determine whether a compound has anti-inflammatory activity. In particular, the novel assays allow the screening of compounds for the purposes of prophylactic and therapeutic use in treating or ameliorating the symptoms of T-cell, macrophage or neutrophil mediated diseases in mammals. In particular, the invention is based on the measurement of the capacity of a substance being an oil or fat, an alcoholic extract of an oil or fat, a biologically active component of an oil or a fat, or a preparation comprising an oil or fat, to suppress the activity of T-cells, macrophages or neutrophils in humans or animals in response to chemical and/or biological agents that activate these cell types. Measurements are made either in vivo (eg in mice) or in an in vitro preparation of human T-cells, macrophages or neutrophils, or a cell line derived therefrom. The substance is, in particular, emu oil or an ethanolic extract thereof.Type: ApplicationFiled: March 3, 2003Publication date: June 9, 2005Inventor: Antonio Ferrante
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Patent number: 6866712Abstract: A fibrous reinforcing material (1) is envisaged which is produced from glass filaments (2), advantageously consisting of fragments of glass yarns (3) or of chopped yarns, having a mean diameter of greater than five micrometers and a mean length of greater than six millimeters. The process comprises a selection step (4a, 4b) during which the glass yarns (3) consisting of filaments having a diameter greater than or equal to five micrometers and less than or equal to twenty-four micrometers are chosen, optionally a step (5) of mixing the selected yarns, and a milling step (6) during which the mixed yarns are chopped into filaments (2) having a length of greater than or equal to six millimeters. Advantageously, the fibrous material is in the form of flakes.Type: GrantFiled: April 12, 2000Date of Patent: March 15, 2005Assignee: Saint-Gobain Vetrotex France S.A.Inventors: Francesco Rossi, Antonio Ferrante
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Publication number: 20040254240Abstract: The present invention relates to pharmaceutical compositions comprising, as an anticancer agent (a) one or more compounds having the formula NO2-A-B, wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 double bonds, and B is (CH2)m(COOH)n in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or a derivative thereof in which the hydrocarbon chain has one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy; (b) one or more compounds selected from polyunsaturated fatty acids (PUFA's) having a 16 to 26 carbon atom chain and 3 to 6 double bonds, and wherein the PUFA is covalently coupled at the carboxylic acid group to an amino acid selected from glycine and aspartic acid; (c) one or more compounds selected from unsaturated fatty acids having an 18 to 25 carbon atom chain and 1 to 6 double bonds and wherein the fatty acid has one or two &bgr;-oxa, &ggr;-oxa, &bgr;-thia, &ggr;-thia substitutions; or (d) one or more compounds havinType: ApplicationFiled: April 5, 2004Publication date: December 16, 2004Inventors: Antonio Ferrante, J. Christopher Easton, S.T. Charles Hll
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Patent number: 6645627Abstract: A filler (1) is envisioned which comprises glass-based granules (2) provided with a sizing composition, in which filler each of the granules (2) consists of a multiplicity of milled glass fragments (3) agglomerated together by the agency of a sizing composition (4) containing especially a compound chosen from esters of alkylsilicic acids, particularly an aminosilane. The process comprises a milling step (6) during which the glassy material is comminuted into fragments by this milling, a metering step (7) during which a mixture including the fragments (3) and the sizing composition (4) is formed and an agglomeration step (8) during which the mixture is dried so as to form granules each including a multiplicity of fragments (3) and dried parts of the sizing composition (4).Type: GrantFiled: June 14, 2002Date of Patent: November 11, 2003Assignee: Saint-Gobain Vetrotex France S.A.Inventors: Francesco Rossi, Antonio Ferrante
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Publication number: 20030092762Abstract: The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A′ is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B′ is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.Type: ApplicationFiled: March 18, 2002Publication date: May 15, 2003Inventors: Antonio Ferrante, Christopher J. Easton, Ling Xia
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Publication number: 20030078299Abstract: The present invention relates to pharmaceutical compositions comprising, as an anti-cancer agent: (a) one or more compounds having the formula NO2—A—B, 1Type: ApplicationFiled: March 18, 2002Publication date: April 24, 2003Inventors: Antonio Ferrante, J. Christopher Easton, S. T. Charles Hii
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Publication number: 20030064021Abstract: The present invention provides peptides capable of stimulating neutrophils. In particular, the peptides prime neutrophils for a respiratory burst following treatment with N-formyl-L-methionyl-L-leucyl-L-phenylalanine. The peptides have an amino acid sequence substantially corresponding to amino acids 54 to 94 of FIG. 1 or a part thereof. These peptides may also be used in the treatment of a subject having depressed neutrophil function.Type: ApplicationFiled: April 10, 2002Publication date: April 3, 2003Applicant: Peptech LimitedInventors: Deborah Ann Rathjen, Antonio Ferrante
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Patent number: 6455466Abstract: This invention relates to compositions and methods for preserving plants and plant parts.Type: GrantFiled: July 17, 2000Date of Patent: September 24, 2002Assignee: The Regents of the University of CaliforniaInventors: Michael A. Reid, Antonio Ferrante, Donald A. Hunter, Wesley P. Hackett
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Patent number: 6375928Abstract: The present invention provides peptides capable of stimulating neutrophils. In particular, the peptides prime neutrophils for a respiratory burst following treatment with N-formyl-L-methionyl-L-leucyl-L-phenylalanine. The peptides have an amino acid sequence substantially corresponding to amino acids 54 to 94 of FIG. 1 or a part thereof. These peptides may also be used in the treatment of a subject having depressed neutrophil function.Type: GrantFiled: June 21, 2000Date of Patent: April 23, 2002Assignee: Peptech LimitedInventors: Deborah Ann Rathjen, Antonio Ferrante
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Patent number: 6376688Abstract: The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two substitutions selected from the group consisting of &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia. It is also preferred that the polyunsaturated fatty acid compound includes a further substitution selected from the group consisting of hydroxy, hydroperoxy, peroxy, carboxymethyl substitutions or attached to an amino acid.Type: GrantFiled: May 29, 1997Date of Patent: April 23, 2002Assignee: Peptide Technology LimitedInventors: Antonio Ferrante, Alfred Poulos, Christopher John Easton, Michael Joseph Pitt, Thomas Alistair Robertson, Deborah Ann Rathjen
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Patent number: 6262119Abstract: Method of treating or ameliorating symptoms of T-cell mediated disease wherein a composition comprising a therapeutically effective amount of a polyunsaturated fatty acid and a pharmaceutically acceptable carrier is administered to the patient. The polyunsaturated fatty acid contains 18-25 carbon atoms, 1-6 double bonds and has 1 or 2 substitutions selected from &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia, based on the fatty acid acyl carbon atom, or the polyunsaturated fatty acid contains 16-26 carbon atoms, 3-double bonds and is covalently coupled at the carboxylic acid group to an amino acid.Type: GrantFiled: April 12, 1999Date of Patent: July 17, 2001Assignees: Peptide Technology Limited, Women's and Children's Hospital AdelaideInventors: Antonio Ferrante, Alfred Poulos, Michael Joseph Pitt, Christopher John Easton, Merilyn Joy Sleigh, Deborah Ann Rathjen, Fred Widmer