Patents by Inventor Antonio MACCHIARULO

Antonio MACCHIARULO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TGR5 modulators and methods of use thereof
    Patent number: 11807659
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Grant
    Filed: April 14, 2022
    Date of Patent: November 7, 2023
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventors: Roberto Pellicciari, Antimo Gioiello, Antonio Macchiarulo, Francoise Perron-Sierra, Klaus Seedorf
  • TGR5 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20220380404
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: April 14, 2022
    Publication date: December 1, 2022
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO, Antonio MACCHIARULO, Francoise PERRON-SIERRA, Klaus SEEDORF
  • TGR5 modulators and methods of use thereof
    Patent number: 11345721
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: May 31, 2022
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventors: Roberto Pellicciari, Antimo Gioiello, Antonio Macchiarulo, Francoise Perron-Sierra, Klaus Seedorf
  • TGR5 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20210122779
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: September 2, 2020
    Publication date: April 29, 2021
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO, Antonio MACCHIARULO, Francoise PERRON-SIERRA, Klaus SEEDORF
  • TGR5 modulators and methods of use thereof
    Patent number: 10800807
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: October 13, 2020
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello, Antonio Macchiarulo, Francoise Perron-Sierra, Klaus Seedorf
  • TGR5 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20190284225
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: June 16, 2016
    Publication date: September 19, 2019
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO, Antonio MACCHIARULO