Patents by Inventor Antonio Machado

Antonio Machado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210392886
    Abstract: The disclosed invention provides agricultural compositions for effective disruption of bacterial biofilms, for the treatment and preventing of bacterial diseases and disorders. The present invention also provides methods for the treatment and of prevention in a plant or plant part thereof, comprising applying to the plant or plant part said agricultural composition.
    Type: Application
    Filed: June 17, 2020
    Publication date: December 23, 2021
    Inventors: Alessandra Alves de Souza Della Coletta, Helvecio Della Coletta Filho, Marco Aurelio Takita, Marcos Antonio Machado, Simone Cristina Picchi, Lígia Segatto Muranaka
  • Publication number: 20160029626
    Abstract: “Cysteine amino-acid compound (or its analogues) used in the disruption of microbial biofilms by treatment of prevention of diseases generated by phytopathogenic bacteria attacking plants of agricultural interest” represented by an innovative solution within the agriculture sector, where said compound can be used in the pharmacological form, as a drug associated with fertilizer for the combat of bacterial diseases which form microbial biofilms, such as citrus variegated chlorosis (CVC), citric canker', huanlongbing (HLB) disease or ‘greening’, amongst other, which inventive concept, as such, never before completed, resides in the benefit deriving from the cysteine amino-acid, and all of its analogues, in the inhibitory action and progressive disruption of the microbial biofilm thus liberating the nutritive flux and hydration of the root to the upper part of the plant and the subsequent regression of the disease symptoms, with the added advantage that the cysteine amino-acid compound is non-toxic, guaranteeing
    Type: Application
    Filed: July 6, 2015
    Publication date: February 4, 2016
    Applicant: INSTITUTO AGRONOMICO DE CAMPINAS - IAC
    Inventors: Alessandra ALVES DE SOUZA, Helvecio DELLA COLETTA FILHO, Marco Aurelio TAKITA, Marcos Antonio MACHADO, Ligia SEGATTO MURANAKA
  • Patent number: 8304450
    Abstract: The invention relates to pharmaceutical compositions comprising anhydrous(2R,3S)4-acetoxy-2-a-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I)(docetaxel) and 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il (2R,3S)3-benzoylamino-2-hydroxy-3-phenylpropionate (II) (paclitaxel), methods for treating neoplastic tumors using anhydrous docetaxel and paclitaxel, and a process for the preparation of the anhydrous docetaxel and paclitaxel.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: November 6, 2012
    Assignees: Quiral Quimica Do Brasil S.A., Biorganica Ltda.
    Inventors: Marco Antônio Santini, Antônio Machado, Aurélio Maranduba, Eneida Guimarães, Marcio Santiago Junior, Maria Silva
  • Patent number: 7838551
    Abstract: This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxy carbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1, 7-?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: November 23, 2010
    Assignees: Quiral Quimica do Basil S.A., Biorganica LTDA.
    Inventors: Marco Antônio Santini, Antônio Machado, Aurélio Maranduba, Eneida Guimarães, Marcio Santiago Junior, Maria Silva
  • Publication number: 20090221688
    Abstract: Pharmaceutical compositions containing polysorbate 80, anhydrous docetaxel (I) or its trihydrate and an organic acid with a pKa between 2.5-4.5 employed as a degradation inhibitor.
    Type: Application
    Filed: February 9, 2006
    Publication date: September 3, 2009
    Applicants: Quiral Quimica DO Brasil S.A., Biorganica Ltda.
    Inventors: Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Livia Machado, Marcio Santiago, JR., Maria Silva
  • Publication number: 20090069409
    Abstract: The invention relates to pharmaceutical compositions comprising anhydrous(2R,3S)4-acetoxy-2-a-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I)(docetaxel) and 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il (2R, 3S)3-benzoylamino-2-hydroxy-3-phenylpropionate (II) (paclitaxel), methods for treating neoplastic tumors using anhydrous docetaxel and paclitaxel, and a process for the preparation of the anhydrous docetaxel and paclitaxel.
    Type: Application
    Filed: August 7, 2008
    Publication date: March 12, 2009
    Applicants: QUIRAL QUIMICA DO BRASIL, BIORGANICA LTDA.
    Inventors: Marco Antonio SANTINI, Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Marcio Santiago Junior, Maria Silva
  • Publication number: 20080051450
    Abstract: This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1, 7?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).
    Type: Application
    Filed: December 10, 2004
    Publication date: February 28, 2008
    Applicant: BIORGANICA LTDA.
    Inventors: Marco Antonio Santini, Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Marcio Santiago, Maria Silva
  • Publication number: 20050134003
    Abstract: A radial lip seal including an annular support with a radially extending portion having an inner periphery. An annular seal lip formed of elastomeric material such as polytetrafluoroethylene is connected to the inner periphery. The lip has an inner side adapted to seal a circumferential surface of a shaft and an outer side. The outer side of the lip has a plurality of grooves or protrusions to vary the diameter of the lip. The varied diameter creates a substantial leak between the outer side of the lip and the circumferential surface. The leak created is sufficient to be detected by a low-pressure air test.
    Type: Application
    Filed: December 17, 2003
    Publication date: June 23, 2005
    Inventors: Steven Bryde, Terrence Christensen, Marcos Teixeira, Marcio Camargo Lima, Antonio Machado, Marcos Santanna