Patents by Inventor Antonio Manca

Antonio Manca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3 imidazolidine derivatives and their use in the production of carbapenem
    Patent number: 8383661
    Abstract: Preparation of new heterocyclic compounds characterized by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1?-methylcarbapenem production.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: February 26, 2013
    Assignee: ACS DOBFAR S.p.A.
    Inventors: Mauro Freccero, Giovanni Fogliato, Antonio Manca, Michele Bassanini
  • 1,3 IMIDAZOLIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF CARBAPENEM
    Publication number: 20110015389
    Abstract: Preparation of new heterocyclic compounds characterised by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1?-methylcarbapenem production
    Type: Application
    Filed: October 1, 2009
    Publication date: January 20, 2011
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Mauro Freccero, Giovanni Fogliato, Antonio Manca, Michele Bassanini
  • PROCESS FOR SYNTHESIZING CARBAPENEM USING RANEY NICKEL
    Publication number: 20100004463
    Abstract: Convenient method for obtaining carbapenem by hydrogenation with Raney Nickel, as an alternative to the known catalytic hydrogenation conducted under hydrogen overpressure in the presence of Palladium, starting from corresponding protected intermediates such as p-nitrobenzylesters and with optional suitable protections of any primary and secondary amino functions structurally present.
    Type: Application
    Filed: June 25, 2009
    Publication date: January 7, 2010
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Antonio MANCA, Riccardo Ambrogio Monguzzi
  • Process for preparing sodium cefoxitin
    Patent number: 7605256
    Abstract: Cefalotin is methoxylated in position 7?, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: October 20, 2009
    Assignee: ACS DOBFAR S.p.A.
    Inventors: Antonio Manca, Riccardo Monguzzi, Maurizio Zenoni, Leonardo Marsili
  • Process for obtaining cefotetan with high yield
    Patent number: 7560545
    Abstract: The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Al3+ ions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which practically tautomer-free cefotetan is obtained.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: July 14, 2009
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Antonio Manca, Riccardo Monguzzi
  • Process for producing Cefepime and cephalosporin analogues
    Patent number: 7479556
    Abstract: Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: January 20, 2009
    Assignee: ACS Dobfar S.p.A.
    Inventors: Antonio Manca, Riccardo Monguzzi, Maurizio Zenoni, Leonardo Marsili
  • PROCESS FOR PREPARING SODIUM CEFOXITIN
    Publication number: 20070027314
    Abstract: Cefalotin is methoxylated in position 7?, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.
    Type: Application
    Filed: June 21, 2006
    Publication date: February 1, 2007
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Antonio MANCA, Riccardo MONGUZZI, Maurizio ZENONI, Leonardo MARSILI
  • PROCESS FOR OBTAINING CEFOTETAN WITH HIGH YIELD
    Publication number: 20060281916
    Abstract: The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Al3+ ions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which practically tautomer-free cefotetan is obtained.
    Type: Application
    Filed: May 12, 2006
    Publication date: December 14, 2006
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Maurizio ZENONI, Antonio MANCA, Riccardo MONGUZZI
  • Process for preparing cephalosporins with salified intermediate
    Patent number: 7071329
    Abstract: Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein: Z is benzathine; and X and R2 are as defined in the specification, is reacted with thiourea. The resulting product may be crystallized as a sodium salt, as an internal salt, or as a pharmaceutically acceptable salt.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: July 4, 2006
    Assignee: ACS Dobfar S.p.A.
    Inventors: Riccardo Monguzzi, Antonio Manca, Leonardo Marsili, Maurizio Zenoni
  • Process for producing Cefepime and cephalosporin analogues
    Publication number: 20060100424
    Abstract: Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.
    Type: Application
    Filed: September 9, 2005
    Publication date: May 11, 2006
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Antonio Manca, Riccardo Monguzzi, Maurizio Zenoni, Leonardo Marsili
  • Crystalline form of cefdinir
    Publication number: 20050209451
    Abstract: A new crystalline form of cefdinir having a dissolution rate less than that of the known crystalline form of the same product.
    Type: Application
    Filed: May 16, 2005
    Publication date: September 22, 2005
    Inventors: Antonio Manca, Bruno Sala, Riccardo Monguzzi
  • Process for preparing cephalosporins with salified intermediate
    Publication number: 20050119478
    Abstract: Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein: Z is benzathine; and X and R2 are as defined in the specification, is reacted with thiourea. The resulting product may be crystallized as a sodium salt, as an internal salt, or as a pharmaceutically acceptable salt.
    Type: Application
    Filed: August 12, 2004
    Publication date: June 2, 2005
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Riccardo Monguzzi, Antonio Manca, Leonardo Marsili, Maurizio Zenoni
  • Process for preparing cephalosporins with salified intermediate
    Publication number: 20050119244
    Abstract: Cephalosporins may be conveniently prepared by a process in which 7-ACA is silylated, acylated, desilylated and then salified to give an intermediate which is eventually cyclized with thiourea.
    Type: Application
    Filed: April 12, 2004
    Publication date: June 2, 2005
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Riccardo Monguzzi, Antonio Manca, Leonardo Marsili, Maurizio Zenoni
  • Crystalline form of cefdinir
    Publication number: 20030204082
    Abstract: A new crystalline form of cefdinir having a dissolution rate less than that of the known crystalline form of the same product.
    Type: Application
    Filed: April 3, 2003
    Publication date: October 30, 2003
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Antonio Manca, Bruno Sala, Riccardo Monguzzi