Abstract: A lateral flow immunoassay for the detection of anti-drug antibodies against a biological drug includes a membrane having a capture area, a sample application area, a flow path from the sample application area to the capture area, and a conjugate area located in the flow path. The conjugate area has said biological drug detectably labeled and the capture area has said biological drug immobilized thereto.

Abstract: A lateral flow immunoassay for the detection of anti-drug antibodies against a biological drug includes a membrane having a capture area, a sample application area, a flow path from the sample application area to the capture area, and a conjugate area located in the flow path. The conjugate area has said biological drug detectably labeled and the capture area has said biological drug immobilized thereto.

Abstract: The invention relates to the field of personalized therapy and, in particular, to a method for classifying a patient suffering from rheumatoid arthritis as a responder or as a non-responder patient to a treatment based on a biological drug.

Abstract: A lateral flow immunoassay for the detection of anti-drug antibodies against a biological drug includes a membrane having a capture area, a sample application area, a flow path from the sample application area to the capture area, and a conjugate area located in the flow path. The conjugate area has said biological drug detectably labeled and the capture area has said biological drug immobilized thereto.

Abstract: The present invention relates to a bottle jack comprising a main body and a shaft that expands or contracts, further comprising: a passage space communicating a hydraulically operated circuit with an unloading circuit through which the controlled outlet of hydraulic fluid from the hydraulically operated circuit and subsequent lowering of the shaft occur; a closure element elastically pushed towards the passage space to prevent the outlet of hydraulic fluid therethrough; a ram assembly elastically pushed in the longitudinal backward movement direction (B) with a force greater than the force with which the closure element is elastically pushed against the passage space; and a telescopic lever assembly which can be lowered by a user to operate the hydraulically operated system.

Abstract: The invention relates to the field of personalized therapy and, in particular, to a method for classifying a patient suffering from rheumatoid arthritis as a responder or as a non-responder patient to a treatment based on a biological drug.

Abstract: Hydraulic press which comprises: a structure which comprises at least one support for supporting the hydraulic press on the floor, a working table intended to house a set of pieces from which at least one piece is separated or removed by means of a compressive force exerted by the hydraulic press. a collection area positioned below the working table receiving the piece separated or removed from the set, and a damper connected between the working table and the structure, capable of being expanded to cause the ascent of the working table with respect to the structure and is capable of being compressed to allow the retained descent of the working table with respect to the structure.

Abstract: The present invention relates to a trolley jack comprising a main body and a lifting element capable of moving up or down for lifting a heavy object, and a lever assembly projecting upwards along a longitudinal axis for allowing a user to manually push and move the jack, where a lower end of the lever assembly is connected in an articulated manner to the main body according to a transverse axis of rotation, the lever assembly being capable of being lowered with respect to said transverse axis of rotation and arranged against the main body. Providing a hinged lever assembly increases jack storage and transport possibilities.

Abstract: The present invention relates to a bottle jack comprising a main body and a shaft that expands or contracts, further comprising: a passage space communicating a hydraulically operated circuit with an unloading circuit through which the controlled outlet of hydraulic fluid from the hydraulically operated circuit and subsequent lowering of the shaft occur; a closure element elastically pushed towards the passage space to prevent the outlet of hydraulic fluid therethrough; a ram assembly elastically pushed in the longitudinal backward movement direction (B) with a force greater than the force with which the closure element is elastically pushed against the passage space; and a telescopic lever assembly which can be lowered by a user to operate the hydraulically operated system.

Abstract: A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.

Abstract: A method for prognosing recurrence of prostate cancer (PCa) in a subject following prostatectomy using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping PCa associated genetic variations comprising use of a DNA microarray. A microarray for use in the described methods.

Abstract: A method for prognosing recurrence of prostate cancer (PCa) in a subject following prostatectomy using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping PCa associated genetic variations comprising use of a DNA microarray. A microarray for use in the described methods.

Abstract: The present invention relates to a group of epilepsy biomarkers comprising (i) SNP rs2740574; (ii) SNP rs1799735; (iii) SNP rs1695; (iv) SNP rs6280; and the locus of the human glutathione S-transferase theta-1 (GSTT1) gene. The invention particularly relates to this group of biomarkers as marker for protection against drug-resistant epilepsy. The group of biomarkers may additionally comprise at least one clinical marker selected from the group comprising (i) a focal seizure with secondary generalization; (ii) age at confirmed diagnosis of epilepsy; (iii) atrophy of hippocampus or medial temporal sclerosis; and (iv) the presence of a brain tumor.

Abstract: A method for prognosing a rheumatoid arthritis phenotype using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping multiple rheumatoid arthritis associated genetic variations comprising use of a DNA microrarray. A microarray for use in the described methods.

Abstract: The present invention refers to a group of biomarkers and to non-invasive in vitro methods for the diagnosis or prognosis of endometriosis, as well as to a kit to perform said methods.

Abstract: The invention relates to extracorporeal methods of analyzing the presence or absence of mutations which cause familial hypercholesterolemia. The inventive methods describe the way in which said mutations can be detected using a DNA sample from an individual and comprising the following: chain reaction of the polymerase with primers which are complementary to the low-density lipoprotein receptor gene; analysis of the amplified product by sequencing; restriction analysis; single strand conformation polymorphism techniques; heteroduplex analysis and analysis of a device on top of a biochip glass support on which oligonucleotide probes are disposed, which can be used to detect the aforementioned mutations in the DNA.