Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.

Abstract: A firearm suppressor includes a muzzle mount; blast, intermediate and distal baffle cups; a distal end cap; and a shroud. The muzzle mount, baffle cups, and end cap thread together at threaded interfaces. Each baffle cup has an externally threaded proximal segment threadably received in the proximally adjacent component. The distal baffle cup has an externally threaded distal segment received in the end cap. The components are shaped and arranged to form sealed interfaces upstream of the threaded interfaces along the flow path of gas through the suppressor. The baffle cups include baffle walls defining chambers sized and arranged to limit first round pop. The baffle walls define vent passages extending along axes oriented at skew angles with respect to the axes of the baffle cups. A distal baffle cup includes an annular recess for reducing the weight of the suppressor adjacent the distal end.

Abstract: A firearm suppressor includes a muzzle mount; blast, intermediate and distal baffle cups; a distal end cap; and a shroud. The muzzle mount, baffle cups, and end cap thread together at threaded interfaces. Each baffle cup has an externally threaded proximal segment threadably received in the proximally adjacent component. The distal baffle cup has an externally threaded distal segment received in the end cap. The components are shaped and arranged to form sealed interfaces upstream of the threaded interfaces along the flow path of gas through the suppressor. The baffle cups include baffle walls defining chambers sized and arranged to limit first round pop. The baffle walls define vent passages extending along axes oriented at skew angles with respect to the axes of the baffle cups. A distal baffle cup includes an annular recess for reducing the weight of the suppressor adjacent the distal end.

Abstract: A firearm suppressor includes a muzzle mount; blast, intermediate and distal baffle cups; a distal end cap; and a shroud. The muzzle mount, baffle cups, and end cap thread together at threaded interfaces. Each baffle cup has an externally threaded proximal segment threadably received in the proximally adjacent component. The distal baffle cup has an externally threaded distal segment received in the end cap. The components are shaped and arranged to form sealed interfaces upstream of the threaded interfaces along the flow path of gas through the suppressor. The baffle cups include baffle walls defining chambers sized and arranged to limit first round pop. The baffle walls define vent passages extending along axes oriented at skew angles with respect to the axes of the baffle cups. A distal baffle cup includes an annular recess for reducing the weight of the suppressor adjacent the distal end.

Abstract: A firearm suppressor includes a muzzle mount; blast, intermediate and distal baffle cups; a distal end cap; and a shroud. The muzzle mount, baffle cups, and end cap thread together at threaded interfaces. Each baffle cup has an externally threaded proximal segment threadably received in the proximally adjacent component. The distal baffle cup has an externally threaded distal segment received in the end cap. The components are shaped and arranged to form sealed interfaces upstream of the threaded interfaces along the flow path of gas through the suppressor. The baffle cups include baffle walls defining chambers sized and arranged to limit first round pop. The baffle walls define vent passages extending along axes oriented at skew angles with respect to the axes of the baffle cups. A distal baffle cup includes an annular recess for reducing the weight of the suppressor adjacent the distal end.

Abstract: A firearm suppressor includes a muzzle mount; blast, intermediate and distal baffle cups; a distal end cap; and a shroud. The muzzle mount, baffle cups, and end cap thread together at threaded interfaces. Each baffle cup has an externally threaded proximal segment threadably received in the proximally adjacent component. The distal baffle cup has an externally threaded distal segment received in the end cap. The components are shaped and arranged to form sealed interfaces upstream of the threaded interfaces along the flow path of gas through the suppressor. The baffle cups include baffle walls defining chambers sized and arranged to limit first round pop. The baffle walls define vent passages extending along axes oriented at skew angles with respect to the axes of the baffle cups. A distal baffle cup includes an annular recess for reducing the weight of the suppressor adjacent the distal end.