Abstract: The present invention is related to the use of compounds or pharmaceutically acceptable salts thereof that modulate astrocytic release of substances through connexin and pannexin hemichannels, for the treatment of psychiatric disorders. Compounds or pharmaceutically acceptable salts thereof used in the present invention comprise any compound that differentially modulates, blocks, opens, inhibits, and/or activates connexin and/or pannexin hemichannels from astrocytes while not affecting gap junctions. The invention is also related to a method for treating psychiatric disorders, comprising administering to a mammal or human a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, that modulates astrocytic release of substances through connexin and pannexin hemichannels. Pharmaceutical compositions and a screening method are also considered in the present invention.

Abstract: The present invention is related to the use of compounds or pharmaceutically acceptable salts thereof that modulate astrocytic release of substances through connexin and pannexin hemichannels, for the treatment of psychiatric disorders. Compounds or pharmaceutically acceptable salts thereof used in the present invention comprise any compound that differentially modulates, blocks, opens, inhibits, and/or activates connexin and/or pannexin hemichannels from astrocytes while not affecting gap junctions. The invention is also related to a method for treating psychiatric disorders, comprising administering to a mammal or human a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, that modulates astrocytic release of substances through connexin and pannexin hemichannels. Pharmaceutical compositions and a screening method are also considered in the present invention.

Abstract: The present invention is directed to an in-line mixer for mixing a plurality of fluids to produce a mixed product. The mixer includes one or more mixing chambers, an impeller in each of the mixing chambers, one or more inlets coupled to injection valves for conveying the fluids into the mixing chamber, and an outlet for conveying the mixed product out of the mixing chamber. The in-line mixer is well suited to components, such as those used in making automotive OEM and refinish paints.

Abstract: The present invention is directed to an in-line mixer for mixing a plurality of fluids to produce a mixed product. The mixer includes one or more mixing chambers, an impeller in each of the mixing chambers, one or more inlets coupled to injection valves for conveying the fluids into the mixing chamber, and an outlet for conveying the mixed product out of the mixing chamber. The in-line mixer is well suited to components, such as those used in making automotive OEM and refinish paints.

Abstract: The present invention is directed to an in-line mixer for mixing a plurality of fluids to produce a mixed product. The mixer includes one or more mixing chambers, an impeller in each of the mixing chambers, one or more inlets coupled to injection valves for conveying the fluids into the mixing chamber, and an outlet for conveying the mixed product out of the mixing chamber. The in-line mixer is well suited to components, such as those used in making automotive OEM and refinish paints.

Abstract: A system which continuously automatically produces paint, particularly for automotive applications, includes tanks of raw materials which are constructed to supply resins, paint concentrates, paint additives, and paint solvents in a fully automated and continuous matter, which results in the production of paints substantially without manual intervention. The system includes a main circulation system which receives the metered dosages of raw materials automatically, collects the raw materials in mixing tanks and which includes outlet pipes which direct the mixture towards a main mixer. The paint is directed to a storage tank, with a portion of the paint being diverted to a control cell which samples the paint and analyzes it and derives from it parametric information which is compared to prestored criteria and which serves to adjust the properties of the ultimately obtained paint as to color, coverage and viscosity.