Abstract: The present invention concerns the use of a neutralizing antibody for matrix metalloproteinase-10 (MMP-10) in the preparation of a medicine useful for anti-fibrinolytic treatment, and for hemorrhages and hemorrhagic complications of various etiologies.

Abstract: The present invention is related to acyclic sulfamide derivatives, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulfamide derivatives are also useful for cosmetic use.

Abstract: The invention relates to the biotechnology sector involving the area of human health. More specifically, the invention is based on the surprising usefulness of peptides LxVPc1, c3 and c4 as efficient selective inhibitors of the calcineurin signalling pathway (CN)-NFAT and the phosphate activity of CN. Said compounds are useful immunosuppressors and serve as a base for the preparation of therapeutic compositions for the prophylactics and treatment of human diseases associated with T-lymphocyte activation, including, but not limited to, autoimmune diseases, inflammation and allergy or transplant rejections. In addition, said peptides and the associated biological and genetic material can form useful tools for the development of tests that can be used to find compounds that have a selective antagonist activity in relation to CN.

Abstract: Provided is a grab and go themed coffee maker that stores and dispenses multiple ingredients into a cup or container with specific amounts of each ingredient according to the individual's beverage preferences and the desired time of day they want the beverage. It can be programmed for multiple users. This invention will accommodate multiple users with their desired hot beverage, their desired ingredients and their desired ingredient quantities at their desired brew time. It contains an LED screen with LED buttons as a user interface. In the interior it has multiple chambers with sensors inside each for storage of ingredients and each has dispensing mechanisms. The exterior tray where the cup or container for beverage is located also has an LED sensor. It also contains a microchip for use as an internal memory to store user interface settings and individual beverage preferences.

Abstract: The invention relates to a method and apparatus for detecting substances or analytes form the analysis of one or several samples. The method comprises mixing the sample with a suitable liquid buffer, homogenizing said sample, adding reagents thereto, filtering it, injecting the sample into the incubation chamber, allowing the sample to react with a biosensor, washing the non-reacted sample excess and detecting the sample retained in the biosensor. The apparatus includes a sample homogenizer module with an ultrasonic piezoelectric device formed by a converter (49) and a horn (16); a sample processing module including a homogenization container (6) and a moving frame (17); a reagent and solution management module including a motorized syringe (60), a reaction module consisting of a support (50) forming a reaction chamber (51) and a data reading module including a laser diode (66) and a CCD camera (67).

Abstract: The present invention is directed to methods, compositions and articles comprising olfactory-active compositions. An article of the present invention comprises a structural component and an olfactory-active composition. The article may control the release, release rate or absorption of the olfactory-active composition. The article may be of various shapes and sizes. A method of use of an article comprises providing fragrance to an environment.

Abstract: A one piece reclosable container for circular cookies or other cookies or food articles having rounded edges that is easy to use, handle, stack, and/or transport. The container comprises a base and a lid hingedly secured together. The lid and bases define two rows of parallel tubular segments when the lid is in the closed position. Each tubular segment defines a plurality of receptacles configured to receive a plurality of the food articles arranged in a side-by-side manner. The base comprises a plurality of base receptacle members defining the receptacles. Each base receptacle member includes a plurality of base shock absorbers configured to maintain the cookies at an elevation when the container is resting on a surface. The lid comprises a plurality of lid shock absorbers and a plurality of lid receptacle members further defining the receptacles. The containers may also be stackable.

Abstract: The present invention relates to the use of matrix metalloproteinase MMP-10 in the preparation of a pharmaceutical composition useful for thrombolytic therapy, it also being possible for said composition to contain a plasminogen activator. Additionally, the present invention relates to said pharmaceutical composition for the treatment of thrombotic disorders.

Abstract: There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.

Abstract: The present invention is related to acyclic sulphamide derivatives of formula (I), wherein R1 and R2 may be the same or different, when R1 and R2 are different, R1 is a linear C12-C20 alkyl group or a linear C12-C20 alkenyl group comprising 1, 2, 3 or 4 double bonds; and R2 is a hydrogen atom or a C1-C4 alkyl group, or when R1 and R2 are the same, R1 and R2 are a linear C14-C20 alkyl group or a linear C14-C20 alkenyl group with 1, 2, 3 or 4 double bonds, and pharmaceutically acceptable salts, solvates and hydrates thereof, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulphamide derivatives are also useful for cosmetic use for reducing subcutaneous fat.

Abstract: The present invention concerns the use of a neutralising antibody for matrix metalloproteinase-10 (MMP-10) in the preparation of a medicine useful for anti-fibrinolytic treatment, and for haemorrhages and haemorrhagic complications of various etiologies.

Abstract: A technique for allocating protection-switching mechanisms operates on a per wavelength basis. This allows a designer of an optical network to select a particular protection switching mechanism for a given traffic type, which is usually specific to a particular wavelength in an optical network. For another traffic type, the designer can allocate a different protection switching mechanism, thereby providing optimal protection switching for each traffic type.

Abstract: The invention relates to the biotechnology sector involving the area of human health. More specifically, the invention is based on the surprising usefulness of peptides LxVPc1, c3 and c4 as efficient selective inhibitors of the calcineurin signalling pathway (CN)-NFAT and the phosphate activity of CN. Said compounds are useful immunosuppressors and serve as a base for the preparation of therapeutic compositions for the prophylactics and treatment of human diseases associated with T-lymphocyte activation, including, but not limited to, autoimmune diseases, inflammation and allergy or transplant rejections. In addition, said peptides and the associated biological and genetic material can form useful tools for the development of tests that can be used to find compounds that have a selective antagonist activity in relation to CN.

Abstract: The present invention is related to acyclic sulphamide derivatives of formula (I), wherein R1 and R2 may be the same or different, when R1 and R2 are different, R1 is a linear C12-C20 alkyl group or a linear C12-C20 alkenyl group comprising 1, 2, 3 or 4 double bonds; and R2 is a hydrogen atom or a C1-C4 alkyl group, or when R1 and R2 are the same, R1 and R2 are a linear C14-C20 alkyl group or a linear C14-C20 alkenyl group with 1, 2, 3 or 4 double bonds, and pharmaceutically acceptable salts, solvates and hydrates thereof, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulphamide derivatives are also useful for cosmetic use for reducing subcutaneous fat.

Abstract: The present invention relates to a computer-aided process for carrying out the structural design of a stiffened panel (9) made of a composite material, optimizing a target variable, comprising a first preparation phase (21) in which a Simulation Model (25) of the stiffened panel (9) with all the relevant information for the structural analysis thereof is obtained from a General Finite Element Model (23) and the modifiable variables and the restrictions (27) are defined, and a second simulation phase (51) in which the design variables are iteratively modified for the purpose of optimizing the target variable, taking into account in each iteration the load distribution changes resulting from the previous iteration, and verifying that the restrictive conditions and the safety margins associated to the pre-established failure modes are met using for that purpose simulation expert modules (55) of families of failure modes.

Abstract: The present invention relates to the use of matrix metalloproteinase MMP-10 in the preparation of a pharmaceutical composition useful for thrombolytic therapy, it also being possible for said composition to contain a plasminogen activator. Additionally, the present invention relates to said pharmaceutical composition for the treatment of thrombotic disorders.

Abstract: A method for obtaining a pharmaceutical composition from Roystonea regia whole fruit including drying, grinding, and sieving the Roystonea regia whole fruit, and separating an extract through a solid/liquid extraction in organic solvents with the organic solvents are selected from hydrocarbons of 5 to 8 carbon atoms, alcohols of 1 to 3 carbon atoms, and mixture thereof, with or without a previous basic hydrolysis using hydroxides or alkalis.

Abstract: A method for treating and/or preventing BPH prostatitis, alopecia and hirsutism including administering a medication of the pharmaceutical composition obtained from the green or mature fruits of Roystonea regia including a mixture of primary fatty acids with 8 to 28 carbon atoms, the fatty acid selected from the group consisting of caprilic acid (C8:0), capric acid (C10:0), lauric acid (C12:0), miristic acid (C14:0), palmitic acid (C16:0), palmitoleic acid (C16:1), stearic acid (C18:0), oleic acid (C18:1), linoleic acid, and linolenic acid and a mixture of esters of the fatty acids, and free fatty acids are enriched from ester hydrolysis.

Abstract: A method for merging protection switching messages in an optical network enables a control of the amount of message bandwidth used for sending protection switching messages. A method for performing protection switching in an optical network does so in an optimal manner by performing the protection switching actions in the various nodes of a protection path in parallel rather than in sequence. To do so, a channel failure message is transmitted from an end node A in the optical network upon detecting a failure in a link in the optical network that includes the end node A. If a failure can be detected at both end nodes, the channel failure messages are transmitted from both end nodes the moment they detect failure without any further waiting. Upon receiving the first channel failure message regardless its originating end node, switching actions in intermediate nodes are initiated.