Abstract: A prediction device is configured to perform a prediction method to predict a risk of chemotherapy-induced peripheral neuropathy, CIPN, in a test subject. The prediction method comprises receiving (211) perception data comprising low-frequency vibration perception data, LF-VPD, and operating (214) at least one prediction model on the perception data to determine at least one risk variable, which is indicative of a risk that the test subject will develop peripheral neuropathy as a result of chemotherapy. The LF-VPD designates measured perception of vibrations at one or more predetermined locations on one or more limbs of the test subject, and represents, for vibrations at each of one or more predefined frequencies below 64 Hz, a vibration energy that causes the test subject to switch between perception and non-perception of the vibrations.

Abstract: Aspects of the disclosure are directed to methods and/or apparatuses involving modifying flow and/or concentration of an agent being injected for characterizing a vascular system. As may be implemented in accordance with one or more embodiments, a liquid including an agent is injected into a vascular system, by dynamically modulating a flow rate of the agent being injected over a range of flow rates. The vascular system is characterized based on a response of the vascular system to the dynamic modulation. In some implementations, such an approach involves using an injector that operates to separately control the rate at which an agent and other liquid such as saline are injected. These approaches can be implemented with modulation schemes using one or more of a variety of functions.

Abstract: A multi-modality phantom is provided. The multi-modality phantom includes a container and an insert. The container defines an exterior that is separated from an interior space and designed to receive a tissue-mimicking medium for an ultrasound imaging process. The container further includes at least one access port formed in the container to perform the ultrasound imaging process of the interior space. The insert can be dimensioned to be selectively arranged within the interior space of the container. The insert includes imaging features arranged to simulate an environment and constructed to yield simultaneous imaging results when performing the ultrasound imaging process and at least one non-ultrasound imaging process.

Abstract: An apparatus (1) is configured to perform a test procedure for measuring vibrotactile perception of a human subject. The apparatus (1) comprises a vibration probe (5) with an end portion (5A) arranged for engagement by a body part (100), a contactless temperature sensor (13) arranged to face the body part (100) when engaged with the end portion (5 A), and a force sensor (7) coupled to the vibration probe (5). A control unit (10) prepares for the test procedure by computing, as a function of a first output signal (TIR) of the contactless temperature sensor (13) and/or a second output signal (f) of the force sensor (7), one or more characteristic parameters indicative of presence or absence of the body part (100). When presence of the body part (100) is indicated by the one or more characteristic parameters, the control unit (10) sets a current temperature of the body part (100) to a current temperature value given by the first output signal (TIR).

Abstract: Aspects of the disclosure are directed to methods and/or apparatuses involving modifying flow and/or concentration of an agent being injected for characterizing a vascular system. As may be implemented in accordance with one or more embodiments, a liquid including an agent is injected into a vascular system, by dynamically modulating a flow rate of the agent being injected over a range of flow rates. The vascular system is characterized based on a response of the vascular system to the dynamic modulation. In some implementations, such an approach involves using an injector that operates to separately control the rate at which an agent and other liquid such as saline are injected. These approaches can be implemented with modulation schemes using one or more of a variety of functions.

Abstract: A multi-modality phantom is provided. The multi-modality phantom includes a container and an insert. The container defines an exterior that is separated from an interior space and designed to receive a tissue-mimicking medium for an ultrasound imaging process. The container further includes at least one access port formed in the container to perform the ultrasound imaging process of the interior space. The insert can be dimensioned to be selectively arranged within the interior space of the container. The insert includes imaging features arranged to simulate an environment and constructed to yield simultaneous imaging results when performing the ultrasound imaging process and at least one non-ultrasound imaging process.

Abstract: Identifying a vibrotactile perception threshold of different mechanoreceptors at a skin site of a subject by detecting sensory deficits in peripheral nerves and, in particular, those associated with neuropathy in the fingers or other parts of the body. Controlling and monitoring of the static dynamic contact force between the human skin site and a vibrating probe which transmits a frequency signal to a receiver for measuring the spatial position of the transmitted signal, whereby a human feedback device records the signal and adjusts for continuous contact force between the skin site and vibrating probe.