Patents by Inventor Antonio TOPPINO

Antonio TOPPINO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of midostaurin with high purity
    Patent number: 11939342
    Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: March 26, 2024
    Assignee: PROCOS S.P.A.
    Inventors: Alberto Lena, Antonio Toppino, Katia Miele, Jacopo Roletto, Paolo Paissoni
  • PROCESS FOR THE PREPARATION OF AMORPHOUS MIDOSTAURIN WITH A LOW CONTENT OF RESIDUAL ORGANIC SOLVENT
    Publication number: 20220251111
    Abstract: The present invention relates to a process for the preparation of an amorphous form of midostaurin with a low content of residual organic solvent.
    Type: Application
    Filed: August 5, 2020
    Publication date: August 11, 2022
    Applicant: Procos S.P.A.
    Inventors: Alberto Lena, Matteo Baudino, Gabriele Prina Cerai, Antonio Toppino, Jacopo Roletto, Paolo Paissoni
  • PROCESS FOR THE PREPARATION OF MIDOSTAURIN WITH HIGH PURITY
    Publication number: 20220098216
    Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.
    Type: Application
    Filed: March 25, 2020
    Publication date: March 31, 2022
    Applicant: PROCOS S.P.A.
    Inventors: Alberto LENA, Antonio TOPPINO, Katia MIELE, Jacopo ROLETTO, Paolo PAISSONI