Patents by Inventor Antonio Victor Osorio-Lozada

Antonio Victor Osorio-Lozada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of thiazolidinethione indene-based chiral auxiliaries
    Patent number: 8309738
    Abstract: Methods for the preparation of indene-based thiazolidinethiones are provided comprising contacting 1-amino-2,3-dihydro-1H-inden-2-ol, or a substituted derivative thereof, with an acid under suitable reaction conditions to provide a first intermediate; and contacting the first intermediate with an alkali xanthate in the presence of an alkali hydroxide under suitable reaction conditions to provide a compound of formula (III), wherein R1-R8 are defined herein.
    Type: Grant
    Filed: January 11, 2010
    Date of Patent: November 13, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Horacio F. Olivo, Antonio Victor Osorio Lozada
  • Methods for the Preparation of Thiazolidinethione Indene-Based Chiral Auxiliaries
    Publication number: 20100179330
    Abstract: Methods for the preparation of indene-based thiazolidinethiones are provided comprising contacting 1-amino-2,3-dihydro-1H-inden-2-ol, or a substituted derivative thereof, with an acid under suitable reaction conditions to provide a first intermediate; and contacting the first intermediate with an alkali xanthate in the presence of an alkali hydroxide under suitable reaction conditions to provide a compound of formula (III), wherein R1-R8 are defined herein.
    Type: Application
    Filed: January 11, 2010
    Publication date: July 15, 2010
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Horacio F. Olivo, Antonio Victor Osorio Lozada
  • Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
    Patent number: 7553646
    Abstract: The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive oxidation-amidation of benzhydrylsulfanyl carboxylic acid to produce racemic and enantiomers of modafinil using at least one microorganism of yeast, bacteria, or fungus. Also disclosed are pharmaceutical compositions of racemic and enantiomers of modafinil along with their use in the treatment of diseases, including attention deficit hyperactivity disorder and drug addiction.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: June 30, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Horacio F. Olivo, Antonio Victor Osorio-Lozada