Patents by Inventor Antonis K. Hatzopoulos

Antonis K. Hatzopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods useful for directing stem cell differentiation
    Patent number: 9040694
    Abstract: The presently-disclosed subject matter relates to compounds of the formula: and methods for use thereof. The presently-disclosed subject matter relates methods of selectively differentiating a stem cell, and methods of screening for compounds useful for enhancing terminal differentiation of committed cardiac progenitor cells.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: May 26, 2015
    Assignee: Vanderbilt University
    Inventors: Charles C. Hong, Corey R. Hopkins, Antonis K. Hatzopoulos, Craig W. Lindsley, Jijun Hao
  • Compounds and methods useful for directing stem cell differentiation
    Patent number: 8822684
    Abstract: The presently-disclosed subject matter relates to compounds of the formula: and methods for use thereof. The presently-disclosed subject matter relates methods of selectively differentiating a stem cell, and methods of screening for compounds useful for enhancing terminal differentiation of committed cardiac progenitor cells.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: September 2, 2014
    Assignee: Vanderbilt University
    Inventors: Charles C. Hong, Corey R. Hopkins, Antonis K. Hatzopoulos, Craig Lindsley, Jijun Hao
  • USE OF ADENOSINE RECEPTOR LIGANDS TO PROMOTE CELL ADHESION IN CELL-BASED THERAPIES
    Publication number: 20090136460
    Abstract: Intracoronary delivery of endothelial progenitor cells (EPCs) is an emerging concept for the treatment of cardiovascular disease, and enhancement of EPC adhesion to vascular endothelium should improve cell retention within targeted organs, as well as vascular development. The present inventors have shown that stimulation of adenosine receptors (AdoR) in murine embryonic EPCs (eEPCs) and cardiac endothelial cells (cECs) rapidly, within minutes, increased eEPC adhesion to cECs. eEPCs and cECs were found to predominantly express functional A1 and A2B AdoR subtypes, respectively, and both subtypes are involved in the regulation of eEPC adhesion to cECs. Adenosine, adenosine precursors (e.g., AMP) and adenosine receptor agonists thus can be used to stimulate EPC/stem cell homing and engraftment in cell-based therapies.
    Type: Application
    Filed: July 10, 2008
    Publication date: May 28, 2009
    Inventors: Italo Biaggioni, Igor Feoktistov, Antonis K. Hatzopoulos, Sergey Ryzhov, Douglas E. Vaughan