Patents by Inventor Antonito T. Panganiban

Antonito T. Panganiban has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VIRAL NUCLEOCAPSID PROTEIN AS A MULTIFUNCTIONAL TRANSLATION INITIATION FACTOR AND INCREASED PROTEIN AND POLYPEPTIDE PRODUCTION USING SAME
    Publication number: 20110189730
    Abstract: The present invention is directed to a system to significantly increase the expression of genes of interest, and in particular proteins and polypeptide products. Expression of hantavirus nucleocapsid protein (N) by itself results in augmented translational expression of diverse genes. The mechanism of this augmentation relies on the ability of N to replace the cellular cap binding complex to attain more efficient translation initiation—the result being great mRNA production and greater protein/polypeptide production. The inventors have also recently found that inclusion of a 5? untranslated leader region (viral UTR) from a viral RNA, in conjunction with N, leads to even more robust expression. This mechanism appears to involve recognition of the viral UTR by the N to provide even more robust protein production.
    Type: Application
    Filed: July 17, 2009
    Publication date: August 4, 2011
    Inventors: Antonito T. Panganiban, Mohammed A. Mir
  • Method of identifying modulators of HIV-1 Vpu and Gag interaction with U binding protein (Ubp)
    Patent number: 6927023
    Abstract: A preparation of U binding protein (Ubp) and a gene sequence encoding Ubp and an anti-Ubp antibody are disclosed. An assay to identify modulators of Ubp/Vpu interaction and Gag/Ubp interaction is also disclosed.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: August 9, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Antonito T. Panganiban, Michael A. Callahan, Mark A. Handley
  • Method of identifying modulators of HIV-1 Vpu and Gag interaction with U binding protein (Ubp)
    Publication number: 20020115830
    Abstract: A preparation of U binding protein (Ubp) and a gene sequence encoding Ubp and an anti-Ubp antibody are disclosed. An assay to identify modulators of Ubp/Vpu interaction and Gag/Ubp interaction is also disclosed.
    Type: Application
    Filed: March 4, 2002
    Publication date: August 22, 2002
    Inventors: Antonito T. Panganiban, Michael A. Callahan, Mark A. Handley
  • Method of identifying modulators of HIV-1 Vpu and Gag interaction with U binding protein (Ubp)
    Patent number: 6392015
    Abstract: A preparation of U binding protein (Ubp) and a gene sequence encoding Ubp and an anti-Ubp antibody are disclosed. An assay to identify modulators of Ubp/Vpu interaction and Gag/Ubp interaction is also disclosed.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: May 21, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Antonito T. Panganiban, Michael A. Callahan, Mark A. Handley
  • METHOD OF IDENTIFYING MODULATORS OF HIV-1 VPU AND GAG INTERACTION WITH U BINDING PROTEIN (UBP)
    Publication number: 20020022221
    Abstract: A preparation of U binding protein (Ubp) and a gene sequence encoding Ubp and an anti-Ubp antibody are disclosed. An assay to identify modulators of Ubp/Vpu interaction and Gag/Ubp interaction is also disclosed.
    Type: Application
    Filed: April 29, 1999
    Publication date: February 21, 2002
    Inventors: ANTONITO T. PANGANIBAN, MICHAEL A. CALLAHAN, MARK A. HANDLEY