Patents by Inventor Antonius G. Hazendonk

Antonius G. Hazendonk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine comprising an immunogenic protein and, as an adjuvant, a substantially non-immunogenic, sequentially homologous peptide
    Patent number: 4946676
    Abstract: The invention relates to a new vaccine comprising a native protein capable of inducing the production of protective antibodies in a host, together with an adjuvant amount of certain proteins or peptides which, as such, are not capable of inducing substantial protective antibody titres but considerably enhance the immunizing activity of said native protein.The amino acid sequences of the adjuvant proteins and peptides show homology with the native proteins. Combination of inactivated picornavirus, such as poliovirus, with adjuvant amounts of denatured picornavirus, such as poliovirus, capsis proteins, in a vaccine, is highly advantageous.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: August 7, 1990
    Assignee: De Staat Der Nederlanden
    Inventors: Antonius L. Van Wezel, Antonius G. Hazendonk, Eduard C. Beuvery