Patents by Inventor Antonius H. N. M. Bruins

Antonius H. N. M. Bruins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4188338
    Abstract: New and useful phenylalkylcarbohydroxamic acids are disclosed of the formula ##STR1## wherein: (a) R is selected from the group consisting of alkoxy of one to six carbon atoms, alkenyloxy of two to six carbon atoms, alkyl of one to six carbon atoms, and benzyloxy;(b) R.sub.1 and R.sub.2 are each selected from the group consisting of hydrogen, alkoxy of one to six carbon atoms, alkenyloxy of two to six carbon atoms, alkyl from one to six carbon atoms, and benzyloxy;(c) R.sub.3 and R.sub.4 are selected from the group consisting of hydrogen or alkyl of one to six carbon atoms;(d) R.sub.5 is hydrogen or R.sub.5 together with R.sub.3 or R.sub.4 represent methylene; and(e) n signifies the number 0 or 1,and non-toxic salts thereof, which novel compounds exert a pronounced inhibition of blood platelet aggregation and accelerate the disaggregation of platelet aggregates already formed.
    Type: Grant
    Filed: December 9, 1977
    Date of Patent: February 12, 1980
    Assignee: Akzona Incorporated
    Inventors: Antonius H. N. M. Bruins, Gerlof Vollema
  • Patent number: 4173652
    Abstract: New and useful phenylalkylcarbohydroxamic acids are disclosed of the formula ##STR1## wherein: (a) R is selected from the group consisting of alkoxy of one to six carbon atoms, alkenyloxy of two to six carbon atoms, alkyl of one to six carbon atoms, and benzyloxy;(b) R.sub.1 and R.sub.2 are each selected from the group consisting of hydrogen, alkoxy of one to six carbon atoms, alkenyloxy of two to six carbon atoms, alkyl from one to six carbon atoms, and benzyloxy;(c) R.sub.3 and R.sub.4 are selected from the group consisting of hydrogen or alkyl of one to six carbon atoms;(d) R.sub.5 is hydrogen or R.sub.5 together with R.sub.3 or R.sub.4 represent methylene; and(e) n signifies the number 0 to 1,and non-toxic salts thereof, which novel compounds exert a pronounced inhibition of blood platelet aggregation and accelerate the disaggregation of platelet aggregates already formed.
    Type: Grant
    Filed: October 31, 1978
    Date of Patent: November 6, 1979
    Assignee: Akzona Incorporated
    Inventors: Antonius H. N. M. Bruins, Gerlof Vollema