Abstract: Mixtures of at least two of the macrocyclic musk fragrances hexadecanolide, cyclopentadecanone and pentadecanolide and methods of using such mixtures are described. These mixtures possess substantivity to proteinaceous and cellulosic substrates which is significantly better than the substantivity of the separate components and are therefore very suitable for perfumes to be applied in products intended for treating skin, hair or textile fibers, such as bath and shower products, shampoos, laundry detergents, rinse conditioners, fabric softeners and the like. The mixtures are thus able to replace polycyclic musk fragrances in such products.