Patents by Inventor Antonius Johannes Maria Berns

Antonius Johannes Maria Berns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic non-human animals depleted in a mature lymphocytic cell-type
    Patent number: 6023010
    Abstract: Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: February 8, 2000
    Assignee: GenPharm International
    Inventors: Paulus Jacobus Angelinus Krimpenfort, Antonius Johannes Maria Berns