Patents by Inventor Antonius Kerkenaar

Antonius Kerkenaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing thiol compounds with bacterial .beta.-lyase
    Patent number: 5578470
    Abstract: A method for preparing thiol compounds, comprising: (1) reacting cysteine by a non-enzymatical addition reaction with a compound having the formula (R.sub.1)(R.sub.2)C.dbd.C(R.sub.3)--CO--R.sub.4 via an --S-- bridge to form a cysteine conjugate, wherein the symbols R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or an optionally saturated and/or heterogeneous hydrocarbon group or wherein a combination of two groups selected from the group consisting of R.sub.1, R.sub.3 and R.sub.4, together with the carbon atoms to which the groups are bonded, form an optionally saturated and/or heterogeneous hydrocarbon ring system of five or six members; and (2) reacting the cysteine conjugate so obtained in a concentration of >1 mM conjugate with a microbial .beta.-lyase to form a thiol compound.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: November 26, 1996
    Assignee: Nederlandse Organisatie Voor Toegepast
    Inventors: Antonius Kerkenaar, Diederik J. M. Schmedding, Jan Berg
  • Method for preparing p-mentha-8-thiol-3-one
    Patent number: 5182194
    Abstract: Method for preparing thiol compounds by coupling cysteine having the formula HS--CH.sub.2 --CH(NH.sub.2)COOH via and --S-- bridge to a hydrocarbon compound and subsequently reacting the cysteine conjugate obtained with .beta.-lyase to form the relevant thiol compounds.
    Type: Grant
    Filed: January 26, 1988
    Date of Patent: January 26, 1993
    Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappe Lijk Onderzoektno
    Inventors: Antonius Kerkenaar, Diederik J. M. Schmedding, Jan Berg
  • Bifunctional oligosaccharides and also active compounds derived therefrom
    Patent number: 4958016
    Abstract: Bifunctional oligosaccharides, characterized by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group having 1-4 carbon atoms or an alkali metal, R.sub.2 represents a single bond or a divalent radical compound of monosaccharides and glc represents glucose, are obtained with the help of a specific microbial lyase cleaving the glucose-glucoronic acid bond in polysaccharides; said bifunctional oligosaccharides can be reacted with all kinds of products like proteins and drugs resulting in products having modified properties like solubility etc.
    Type: Grant
    Filed: June 3, 1988
    Date of Patent: September 18, 1990
    Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno
    Inventors: Antonius Kerkenaar, Diederik J. M. Schmedding, Ronald T. M. Van Den Dool
  • Method for controlling vascular withering diseases in plants, especially dutch elm disease
    Patent number: 4814331
    Abstract: Method for controlling vascular withering diseases in plants, especially trees, such as controlling Dutch elm disease by a propylactic or curative treatment of plants with a systemic fungicide which inhibits sterol biosynthesis.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: March 21, 1989
    Assignee: Nederlandse Organisatie Voor et al.
    Inventor: Antonius Kerkenaar