Abstract: An aseptic protector for skin penetrating devices includes a body of deformable material for accepting and encapsulating a protruding portion of a skin penetrating device, such as a pin or drain, from a location where the skin penetrating device protrudes from a skin surface to a location spaced outwardly from the skin surface. The body of deformable material functions as a buffer and inhibits movement of the skin penetrating device. The body of deformable material includes an aseptic agent, preferably dispersed throughout the body of material, for contacting the skin surface and the skin penetrating device at the location where the skin penetrating device penetrates the skin surface to prevent, inhibit or arrest infection where the skin penetrating device penetrates the skin surface.