Patents by Inventor Antonius Ter Laak

Antonius Ter Laak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION
    Publication number: 20160089364
    Abstract: The invention relates to a pharmaceutical composition for non-hormonal, on-demand contraception and to processes for preparing this pharmaceutical composition. The latter comprises 2H-indazole as novel EP2 receptor antagonists in combination with COX inhibitors. The invention furthermore provides a method for non-hormonal female-controlled on-demand contraception where a pharmaceutical composition comprising EP2 receptor antagonists in combination with COX inhibitors is taken on demand prior to expected sexual intercourse.
    Type: Application
    Filed: May 16, 2014
    Publication date: March 31, 2016
    Applicants: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Bernhard LlNDENTHAL, Nico BRÄUER, Peter SERNO, Andrea ROTGERI, Ulrike FUHRMANN, Bernd BUCHMANN, Anne MENGEL, Ulrike RÖHN, Antonius TER LAAK
  • -indazoles as EPreceptor antagonists
    Patent number: 9062041
    Abstract: The present invention relates to novel 2H-indazoles of the general formula (I), methods for the preparation thereof and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are linked with the EP2-receptor.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: June 23, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Nico Bräuer, Anne Mengel, Ulrike Charlotte Röhn, Andrea Rotgeri, Bernd Buchmann, Bernhard Lindenthal, Antonius Ter Laak
  • 6,7-Dihydro-5H-benzo[7]annulene derivatives, processes for their preparation, pharmaceutical products comprising them and their use for preparing medicaments
    Publication number: 20150080438
    Abstract: The invention relates to selective oestrogen receptor modulators (SERMs) and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.
    Type: Application
    Filed: December 4, 2012
    Publication date: March 19, 2015
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Tim Wintermantel, Carsten Moeller, Ulrich Bothe, Reinhard Nubbemeyer, Ludwig Zorn, Antonius Ter Laak, Rolf Bohlmann, Lars Wortmann
  • Novel 2H-Indazoles as EP2 Receptor Antagonists
    Publication number: 20140336172
    Abstract: The present invention relates to novel 2H-indazoles of the general formula (I), methods for the preparation thereof and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are linked with the EP2-receptor.
    Type: Application
    Filed: November 26, 2012
    Publication date: November 13, 2014
    Inventors: Nico Bräuer, Anne Mengel, Ulrike Röhn, Andrea Rotgeri, Bernd Buchmann, Bernhard Lindenthal, Antonius Ter Laak
  • 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS
    Publication number: 20130252890
    Abstract: The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.
    Type: Application
    Filed: June 21, 2011
    Publication date: September 26, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Tim Wintermantel, Carsten Möller, Ulrich Bothe, Reinhard Nubbemeyer, Ludwig Zorn, Dirk Kosemund, Antonius Ter Laak, Rolf Bohlmann, Lars Wortmann, Donald Bierer
  • 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents
    Patent number: 7977325
    Abstract: This invention relates to compounds of general formula I in which R1 and R2 are described in this application, the use of the compounds of general formula I as inhibitors of protein tyrosine kinases for treatment of various diseases as well as the compounds of general formulas II and III as intermediate compounds for the production of compounds of general formula I, wherein X, R1a and R2a have the meaning that is described in general formulas II and III.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: July 12, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Wolfgang Schwede, Hermann Kuenzer, Antonius Ter Laak, Benjamin Bader, Roman Hillig, Ursula Moenning, Arndt Schmitz, Dieter Zopf
  • Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same
    Patent number: 7842809
    Abstract: The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: November 30, 2010
    Assignee: Bayer Schering Pharma AG
    Inventors: Wolfgang Schwede, Hans Briem, Hermann Kuenzer, Manfred Husemann, Georg Kettschau, Martina Schaefer, Antonius Ter Laak, Karl-Heinz Thierauch, Stuart James Ince
  • Substituted arylpyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
    Patent number: 7795264
    Abstract: The invention relates to substituted arylpyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: September 14, 2010
    Assignee: Bayer Schering Pharma AG
    Inventors: Ingo Hartung, Georg Mendelstr Kettschau, Karl-Heinz Thierauch, Hans Briem, Philip Lienau, Antonius Ter Laak
  • Indolylamides as modulators of the EP2 receptor
    Publication number: 20100029599
    Abstract: The present invention relates to indolylamide derivatives of the general formula (I), to processes for preparation thereof and to use thereof for production of pharmaceutical compositions for treatment of disorders and indications associated with the EP2 receptor.
    Type: Application
    Filed: July 29, 2009
    Publication date: February 4, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Marcus Koppitz, Antonius Ter Laak, Tim Wintermantel, Bernhard Lindenthal, Nico Bräuer, Gernot Langer, Bernd Buchmann
  • Extended Benzamide Derivatives as Modulators of the EP2 Receptor
    Publication number: 20100029598
    Abstract: The present invention relates to extended benzamide derivatives of the general formula I, to processes for preparation thereof and to use thereof for production of pharmaceutical compositions for treatment of disorders and indications associated with the EP2 receptor.
    Type: Application
    Filed: July 24, 2009
    Publication date: February 4, 2010
    Applicant: Bayer Schering Pharma AG
    Inventors: Marcus Kopitz, Bernhard Lindenthal, Antonius Ter Laak, Tim Wintermantel, Olaf Peters, Gernot Langer, Nico Braeuer, Bernd Buchmann
  • THIENOPYRIMIDYLAMINES AS MODULATORS OF THE EP2 RECEPTOR
    Publication number: 20090042878
    Abstract: The present invention relates to thienopyrimidylamines of the general formula I, to processes for their preparation and to their use for production of pharmaceutical compositions for treatment of disorders and indications connected to the EP2 receptor.
    Type: Application
    Filed: July 10, 2008
    Publication date: February 12, 2009
    Inventors: Nico BRAEUER, Bernd Buchmann, Marcus Koppitz, Olaf Peters, Antonius Ter Laak, Bernhard Lindenthal, Gernot Langer, Tim Wintermantel
  • SUBSTITUTED ACETAMIDES AS MODULATORS OF THE EP2 RECEPTOR
    Publication number: 20090042882
    Abstract: The present invention relates to substituted acetamides of the general formula I, process for their preparation, and the use thereof for the manufacture of pharmaceutical compositions for the treatment of disorders and indications connected with the EP2 receptor.
    Type: Application
    Filed: June 12, 2008
    Publication date: February 12, 2009
    Inventors: Bernd BUCHMANN, Nico Braeuer, Olaf Peters, Knut Eis, Marcus Koppitz, Bernhard Lindenthal, Gernot Langer, Tim Wintermantel, Antonius Ter Laak
  • Indolylalkylthienopyrimidylamines as modulators of the EP2 receptor
    Publication number: 20090042913
    Abstract: The present invention relates to indolylalkylthienopyrimidylamines of the general formula I, to processes for their preparation and to their use for production of pharmaceutical compositions for treatment of disorders and indications connected to the EP2 receptor.
    Type: Application
    Filed: July 11, 2008
    Publication date: February 12, 2009
    Inventors: Nico BRAEUER, Bernd Buchmann, Marcus Koppitz, Olaf Peters, Antonius Ter Laak, Bernhard Lindenthal, Gemot Langer, Tim Wintermantel
  • 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents
    Publication number: 20090030010
    Abstract: This invention relates to compounds of general formula I in which R1 and R2 are described in this application, the use of the compounds of general formula I as inhibitors of protein tyrosine kinases for treatment of various diseases as well as the compounds of general formulas II and III as intermediate compounds for the production of compounds of general formula I, whereby X, R1a and R2a have the meaning that is described in general formulas II and III.
    Type: Application
    Filed: December 14, 2005
    Publication date: January 29, 2009
    Inventors: Wolfgang Schwede, Hermann Kuenzer, Antonius Ter Laak, Benjamin Bader, Roman Hillig, Ursula Moenning, Arndt Schmitz, Dieter Zopf
  • ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR
    Publication number: 20090023741
    Abstract: The present invention relates to aryl/hetarylamide derivatives of the general formula I, process for their preparation, and the use thereof for the manufacture of pharmaceutical compositions for the treatment of disorders and indications connected with the EP2 receptor.
    Type: Application
    Filed: June 12, 2008
    Publication date: January 22, 2009
    Inventors: Bernd Buchmann, Nico Braeuer, Olaf Peters, Knut Eis, Marcus Koppitz, Bernhard Lindenthal, Gernot Langer, Tim Wintermantel, Antonius Ter Laak
  • DIAMINOPYRIMIDINES AS MODULATORS OF THE EP2 RECEPTOR
    Publication number: 20090023738
    Abstract: The present invention relates to diaminopyrimidines of the general formula I, process for their preparation, and the use thereof for the manufacture of pharmaceutical compositions for the treatment of disorders and indications connected with the EP2 receptor.
    Type: Application
    Filed: June 19, 2008
    Publication date: January 22, 2009
    Inventors: Nico Braeuer, Bernd Buchmann, Marcus Koppitz, Antonius Ter Laak, Gernot Langer, Bernhard Lindenthal, Olaf Peters, Tim Wintermantel
  • N-(1-Phthalazin-1-ylpiperidin-4-yl)amides as EP2 receptor modulators
    Publication number: 20080146576
    Abstract: The present invention relates to phthalazin-1-ylpiperidin-4-ylamides of the general formula I, to processes for their preparation and to their use for producing pharmaceutical compositions for treatment of disorders and indications connected to the EP2 receptor.
    Type: Application
    Filed: September 6, 2007
    Publication date: June 19, 2008
    Inventors: Nico Braeuer, Bernd Buchmann, Koppitz Marcus, Antonius Ter Laak, Gernot Langer, Bernard Lindenthal, Olaf Peters, Tim Wintermantel
  • 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioureas as modulators of the EP2 receptor
    Publication number: 20080125435
    Abstract: The present invention relates to aryl-3-[(het)aryl-piperidin-4-yl]-thioureas, processes for the production thereof and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are connected with the EP2 receptor.
    Type: Application
    Filed: September 6, 2007
    Publication date: May 29, 2008
    Inventors: Nico Brauer, Bernd Buchmann, Christoph Huwe, Marcus Koppitz, Antonius Ter Laak, Gernot Langer, Bernhard Lindenthal, Olaf Peters, Tim Wintermantel
  • N-(1-hetarylpiperidin-4-yl)(het)arylamides as EP2 receptor modulators
    Publication number: 20080125463
    Abstract: The present invention relates to (het)aryl-3-[(het)arylpiperidin-4-yl]amides, to processes for their preparation and to their use for producing pharmaceutical compositions for treatment of disorders and indications connected to the EP2 receptor.
    Type: Application
    Filed: September 6, 2007
    Publication date: May 29, 2008
    Inventors: Nico Braeuer, Bernd Buchmann, Marcus Koppitz, Antonius Ter Laak, Gernot Langer, Bernhard Lindenthal, Olaf Peters, Tim Wintermantel
  • SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
    Publication number: 20080064707
    Abstract: The invention relates to substituted arylpyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
    Type: Application
    Filed: June 12, 2007
    Publication date: March 13, 2008
    Inventors: Ingo Hartung, Georg Kettschau, Karl-Heinz Thierauch, Hans Briem, Philip Lienau, Antonius Ter Laak