Patents by Inventor Antony J. Mathews

Antony J. Mathews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
    Patent number: 7049406
    Abstract: The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: May 23, 2006
    Assignees: Baxter Biotech Technology SARL, William Marsh Rice University
    Inventors: Michael J Weickert, Christopher B Glascock, Antony J Mathews, Douglas D Lemon, Daniel H Doherty, John S Olson
  • Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
    Publication number: 20030017537
    Abstract: The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
    Type: Application
    Filed: March 27, 2002
    Publication date: January 23, 2003
    Applicant: Baxter Biotech Technology SARL William Marsh Rice Univ.
    Inventors: Michael J. Weickert, Christopher B. Glascock, Antony J. Mathews, Douglas D. Lemon, Daniel H. Doherty, John S. Olson
  • Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
    Patent number: 6455676
    Abstract: The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: September 24, 2002
    Assignees: Baxter Biotech Technology SARL, William Marsh Rice Univerisity
    Inventors: Michael J. Weickert, Christopher B. Glascock, Antony J. Mathews, Douglas D. Lemon, Daniel H. Doherty, John S. Olson
  • Globins containing binding domains
    Patent number: 6218513
    Abstract: The present invention relates to globins containing non-naturally occurring binding domains, In particular, the present invention is directed toward a binding domain comprising the oligomerizing domain GCN4 and GCN4 derivatives. Thc present invention also relates to multimeric hemoglobins comprised of at least one globin containing at least one non-naturally occurring binding domain.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: April 17, 2001
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Spencer J. Anthony-Cahill, Janet K. Epp, Bruce A. Kerwin, Peter O. Olins, Antony J. Mathews
  • Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
    Patent number: 6204009
    Abstract: This invention relates to recombinant hemoglobins containing mutations in or near the heme pocket of the hemoglobin molecule. This invention particularly relates to recombinant hemoglobins that have altered geometry or polarity around the distal portion of the heme pocket.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: March 20, 2001
    Assignee: Baxter Biotech Technology Sàrl
    Inventors: John S. Olson, Antony J. Mathews, Jacqueline F. Aitken, Kyoshi Nagai
  • Production and use of multimeric hemoglobins
    Patent number: 6184356
    Abstract: DNA molecules which encode pseudodimeric globin-like polypeptides with an asymmetric cysteine mutation suitable for crosslinking two tetramers, or which encode pseudooligomeric globin-like polypeptides comprising four or more globin-like domains, are useful in the preparation of multimeric hemoglobin-like proteins.
    Type: Grant
    Filed: April 13, 1998
    Date of Patent: February 6, 2001
    Assignee: Baxter Biotech Technology Sarl
    Inventors: David C. Anderson, Antony J. Mathews, Gary L. Stetler
  • Modified hemoglobin-like compounds and methods of purifying same
    Patent number: 6150506
    Abstract: The present invention relates to modified hemoglobin-like polypeptides containing multiple dialpha (or dibeta) domains. The present invention also relates to multimeric hemoglobin-like proteins comprising covalently joined hemoglobin-like moieties. Another aspect of the inention is directed at a purification method of hemoglobin-like polypeptides utilizing ion exchange chromatography.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: November 21, 2000
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Stephen P. Trimble, Antony J. Mathews, Bruce A. Kerwin, David A. Marquardt, Spencer Anthony-Cahill, Janet K. Epp, Dominic G. Madril, David C. Anderson
  • Mutant recombinant hemoglobins containing heme pocket mutations
    Patent number: 6022849
    Abstract: This invention relates to recombinant hemoglobins containing mutations in or near the heme pocket of the hemoglobin molecule. This invention particularly relates to recombinant hemoglobins that have altered geometry or polarity around the distal portion of the heme pocket.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: February 8, 2000
    Assignee: Baxter Biotech Technology Saarl
    Inventors: John S. Olson, Antony J. Mathews, Jacqueline F. Aitken, Kyoshi Nagai
  • Modified hemoglobin-like compounds
    Patent number: 5844090
    Abstract: The present invention relates to modified hemoglobin-like compounds. The novel compounds include a globin-like polypeptide containing at least two di-alpha domains and multimeric hemoglobin-like proteins having a core hemoglobin-like moiety directly attached to at least two other hemoglobin-like moieties. The invention also relates to nucleic acid molecules encoding the novel polypeptides. Methods of making the multimeric hemoglobin-like proteins are also provided, as well as compositions containing the proteins.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 1, 1998
    Assignee: Somatogen, Inc.
    Inventors: David C. Anderson, Antony J. Mathews, Stephen P. Trimble, Spencer Anthony-Cahill
  • Purification of hemoglobin
    Patent number: 5840851
    Abstract: The present invention generally relates to methods for purifying hemoglobin solutions and to hemoglobin solutions obtained by the methods. In one aspect, such methods include removing contaminants in crude hemoglobin-containing lysates with heat treatment. In a further aspect, the present invention provides methods for producing substantially purified hemoglobin solutions using immobilized metal affinity chromatography, optionally following by anion exchange chromatography.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: November 24, 1998
    Inventors: J. Jeffrey Plomer, James R. Ryland, Maura-Ann H. Matthews, David W. Traylor, Erin E. Milne, Steven L. Durfee, Antony J. Mathews, Justinian O. Neway
  • Production and use of multimeric hemoglobins
    Patent number: 5599907
    Abstract: Multimeric hemoglobin-like proteins are obtained by crosslinking cysteines of the component tetramers, or by genetically fusing globin-like domains of one tetramer with those of another, by means of an interdomain spacer sequence. Artificial cysteines are introduced selectively in a single globin-like domain per tetramer to control polymerization.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: February 4, 1997
    Assignee: Somatogen, Inc.
    Inventors: David C. Anderson, Antony J. Mathews, Gary L. Stetler