Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.

Abstract: Ion detectors of the type used in scientific instrumentation, such as mass spectrometers. More particularly, a self-contained particle detector includes an enclosure formed in part by a transmission mode secondary electron emissive element, the enclosure defining an internal environment and an external environment, wherein the transmission mode secondary electron emissive element has an externally facing surface and an internally facing surface and is configured such that impact of a particle on the externally facing surface causes emission of one or more secondary electrons from the internally facing surface.

Abstract: A system and method for locating electronic devices and establishing peer to peer communication with electronic devices, such as a currency exchange unit, using a beacon, is disclosed. The method may include determining a location of the currency exchange unit; generating a message indicating a location of the currency exchange unit and the availability of a variety of different currencies; and managing currency exchanges with various mobile devices.

Abstract: A user device may obtain access control data which is derived based on a test result or score of a test for assessing a risk of a user of having or developing a contagious illness. The access control data may be communicated from the user device to an access control system in response to a reading of the user device by the access control system. The access control system may permit or deny entry of the user into an area based on the access control data. In some aspects, the user device is an identity (ID) or access badge. In other aspects, the user device is a mobile user device having one or more illness risk factor assessment functions, where the test result or score is obtained based on resulting data from executing the one or more illness risk factor assessment functions.

Abstract: A pointing controller enables interaction with virtual objects in a virtual or augmented reality environment. The pointing controller comprises a form factor that enables it to be securely positioned in the user's fingers during a pointing gesture. The pointing controller tracks a pointing direction in three-dimensional space based on motion of the pointing controller. The pointing controller furthermore includes one or more control elements such as buttons or touch interfaces to enable additional interactions.

Abstract: An artificially intelligent loan recommendation agent and a method of making loan recommendations are disclosed. The artificially intelligent loan recommendation agent can classify applicants into traditional and non-traditional categories. Based on this categorization, the agent may use different information to make loan recommendations for the applicant. For non-traditional applicants, applicant rating information can be used, including ratings of an applicant’s professional skills obtained from consumer review sites. The agent can also conduct virtual interviews and analyze body language and speech to determine if an applicant may be lying.

Abstract: A method for authenticating signatures is disclosed. The method includes measuring dynamic properties of the signature as the signature is created. The method includes recording pressure and velocity information as an electronic signature is created on an electronic device. The recorded pressure and velocity information may be compared with stored pressure and velocity information to determine if the signature is authentic.

Abstract: A system and method for a guided inspection of an apartment, home or other physical space is disclosed. The system and method use augmented reality to guide a user through a physical space. The system and method further use machine learning to automatically detect and classify damage to various physical structures in the physical space. In response to detected damage, the system may prompt a user to move closer to the detected damage for further inspection. The system can also detect obscured structures and prompt a user to make changes to the environment to increase the visibility of the obscured structures.

Abstract: The present disclosure relates to a system, method, and apparatus for managing orders and invoices among customers of a retail merchant. The system allows a first customer to establish trusted links with one or more associated fellow customers, thereby authorizing the fellow customers to add purchases to the first customer's invoice. This allows a primary customer to purchase items for a secondary customer under tightly controlled and well communicated conditions, without extra work from the merchant. The system also uses location aware services on customer's smartphones to provide data that enhances the customers' experiences, by triggering prompts to open and close and invoice. The system also uses location aware services to determine which other customers may be in a related party together.

Abstract: Ion detectors of the type used in scientific instrumentation, such as mass spectrometers. More particularly, a self-contained particle detector includes an enclosure formed in part by a transmission mode secondary electron emissive element, the enclosure defining an internal environment and an external environment, wherein the transmission mode secondary electron emissive element has an externally facing surface and an internally facing surface and is configured such that impact of a particle on the externally facing surface causes emission of one or more secondary electrons from the internally facing surface.

Abstract: A system and method for locating electronic devices and establishing peer to peer communication with electronic devices, such as a currency exchange unit, using a beacon, is disclosed. The method may include determining a location of the currency exchange unit; generating a message indicating a location of the currency exchange unit and the availability of a variety of different currencies; and managing currency exchanges with various mobile devices.

Abstract: A pointing controller worn by a user enables intuitive control of various connected smart devices. Users may indicate which device is to be controlled by pointing in the direction of the smart device (or a proxy object) and performing a predefined action to select the device for control. Once selected, the user may interact with the smart device by performing various gestures or interactions with one or more control elements integrated into the pointing controller. The smart device may provide feedback using visual or auditory indicators on the smart device, or by sending a control signal to the pointing controller or other device in proximity to the user that provides haptic, auditory, or visual feedback.

Abstract: A system and method for locating mobile communication devices in a peer to peer communication using a beacon. The system and method include determining a first location of a first mobile communication device and transmitting the beacon from the first mobile communication device, which may be received by a second mobile computing device. In response to the beacon, the first mobile communication device may receive a message from a second mobile communication device. A peer to peer communication between the first mobile communication device and the second mobile communication device based on the message may be established. The first mobile communication device may receive a second location of the second mobile communication device from the second mobile communication device, and display both the first location and the second location on a map of the first mobile communication device.

Abstract: A system and method for a guided inspection of an apartment, home or other physical space is disclosed. The system and method use augmented reality to guide a user through a physical space. The system and method further use machine learning to automatically detect and classify damage to various physical structures in the physical space. In response to detected damage, the system may prompt a user to move closer to the detected damage for further inspection. The system can also detect obscured structures and prompt a user to make changes to the environment to increase the visibility of the obscured structures.

Abstract: An energy dissipation device (1) is provided for a car body of a multi-element vehicle in particular a rail vehicle, the energy dissipation device (1) having a damping unit (10) having a regeneratively implemented damping element (11) for damping traction and impact forces occurring in normal travel operation and an energy dissipation unit (20) having a destructively implemented energy dissipation element (21), and the energy dissipation element (21) being designed to respond after a previously determinable critical impact force is exceeded and to transmit at least a part of the impact forces transmitted via the energy dissipation device (1) into heat and deformation work by plastic deformation and thus dissipate them.

Abstract: The present invention relates to an automatic central buffer coupling, especially of the “Tlghtlock/AAR” type of construction. The coupling includes a coupling head, with a supporting unit underneath; a hydraulic and/or compressed air terminal for a hydraulic or compressed air line; and an electrical contact carrier arranged underneath the supporting unit and having electrical contact terminals; and an actuating device to longitudinally displace the electrical contact carrier via the air line. The electrical contact carrier is in an uncoupled position rearward of the coupling plane of the central buffer coupling, and is displaceable into a coupling-ready forward position in the coupling plane via the actuating device. In order to ensure that the electrical contact carrier is automatically co-coupled after the mechanical coupling operation, a release mechanism is configured to ensure a coupling mechanism is triggered to co-couple the at least one hydraulic and/or compressed air terminal.

Abstract: A ridge end assembly for a hipped roof is disclosed in which panel-supporting elongate members of the hipped roof are connected to the ridge end by connectors which are provided with means for locating lengths of sealing material betwen panels supported, in use, by the panel supporting members and an overlying ridge end cap. In one embodiment, the ridge assembly can include a ridge structure, a ridge cap for fitting atop the ridge structure, the ridge cap having a channel at its underside, and at least one fastener having an enlarged part for reception and retention in the channel, the fastener comprising a flexible tie by means of which the cap can be drawn into place on the ridge structure and then secured by a locking member co-operating with the tie.

Abstract: The present invention relates to an automatic central buffer coupling, especially of the “Tlghtlock/AAR” type of construction. The coupling includes a coupling head, with a supporting unit underneath; a hydraulic and/or compressed air terminal for a hydraulic or compressed air line; and an electrical contact carrier arranged underneath the supporting unit and having electrical contact terminals; and an actuating device to longitudinally displace the electrical contact carrier via the air line. The electrical contact carrier is in an uncoupled position rearward of the coupling plane of the central buffer coupling, and is displaceable into a coupling-ready forward position in the coupling plane via the actuating device. In order to ensure that the electrical contact carrier is automatically co-coupled after the mechanical coupling operation, a release mechanism is configured to ensure a coupling mechanism is triggered to co-couple the at least one hydraulic and/or compressed air terminal.

Abstract: A protective plate assembly comprises a plurality of overlapping rigid plates (1, 2, 3) for covering a wearer's chest and abdomen, the plates being attached together such that the amount of overlap between successive plates is variable. Elements (13, 16) of compressible material are provided, distributed on an inner side of the assembly, such that when the amount of overlap between the plates (1, 2, 3) increases, the elements move closer together in the direction in which said overlap increases, and vice versa. Two adjacent plates of the assembly are attached to each other by means of a peg (12) extending from one of said plates, which peg is captive within a slot (9) on the other of said plates, the slot running substantially perpendicular to the overlapping edges of the plates.

Abstract: A device (1) is provided for horizontal resetting to center for a central buffer coupling arranged pivotably by a coupling shaft (2) on a rail-borne vehicle. The device has a guide (3) following the pivoting movement of the coupling shaft (2) around its vertical pivot axis. The device has pressing surfaces (4) provided symmetrically to the longitudinal axis of the coupling shaft (2), and has a pressing device (7), with parts supported against an articulated housing (5) for the coupling shaft and bringing about the horizontal resetting to center. The pressing device acts permanently or switches off or can be switched off depending on the pivot angle or can be actuated by a pneumatically, hydraulically or electrically operated actuating device. To facilitate especially the coupling in tight curves or to make it possible in the first place, the actuating device is designed as a remote-controllable adjusting drive (11).