Patents by Inventor Antti S. Haapalinna

Antti S. Haapalinna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5498623
    Abstract: The invention provides compounds of the formula ##STR1## wherein Y is --CH.sub.2 -- or --CO--;R.sub.1 is F, Cl or OH; R.sub.2 is H, F or Cl; and R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3, excluding 4-(5-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole and 4-(4-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole; and their non-toxic acid addition salts and mixtures thereof. Processes for the preparation of these compounds are described, as are pharmaceutical compositions comprising at least one of the compounds or its salt. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are highly selective and long acting antagonists at .alpha..sub.2 -adrenoceptors. Their peroral bioavailability is good. The compounds are especially useful in the treatment of cognitive disorders.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: March 12, 1996
    Assignee: Orion-yhtyma Oy
    Inventors: Arto J. Karjalainen, Raimo E. Virtanen, Arja L. Karjalainen, Maire M. Eloranta, Jarmo S. Salonen, Hannu T. Sipila, Antti S. Haapalinna