Abstract: The present disclosure relates to the use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea or 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea, or a pharmaceutically acceptable salt thereof, in combination with a MAPKAP pathway inhibitor such as for example a RAS, RAF, MEK, or ERK inhibitor for the treatment of mastocytosis.

Abstract: A device may receive historical project data identifying experiences and/or work product from previous projects and client data identifying a client with a problem, and may process the historical project data and the client data, with machine learning models, to generate recommendations for the problem and confidence scores for the recommendations. The device may process the recommendations and the confidence scores, with an NLG model, to generate a solution to the problem and content for the solution, and may generate a digitized dynamic client solution to the problem based on the solution and the content. The device may provide the digitized dynamic client solution to a user device, and may receive feedback on the digitized dynamic client solution from the user device. The device may generate a final digitized dynamic client solution based on the feedback, and may perform actions based on the final digitized dynamic client solution.

Abstract: The present disclosure relates to the use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea or 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea, or a pharmaceutically acceptable salt thereof, in combination with a MAPKAP kinase inhibitor for the treatment of cancers, including c-KIT-mediated cancers, such as GIST.

Abstract: The present invention relates to novel substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.

Abstract: The present invention relates to novel blood-brain barrier (BBB) penetrable substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.

Abstract: The present disclosure relates to the use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea or 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea, or a pharmaceutically acceptable salt thereof, in combination with a MAPKAP pathway inhibitor such as for example a RAS, RAF, MEK, or ERK inhibitor for the treatment of mastocytosis.

Abstract: The present disclosure relates to the use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea or 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea, or a pharmaceutically acceptable salt thereof, in combination with a MAPKAP kinase inhibitor for the treatment of cancers, including c-KIT-mediated cancers, such as GIST.

Abstract: A device may receive historical project data identifying experiences and/or work product from previous projects and client data identifying a client with a problem, and may process the historical project data and the client data, with machine learning models, to generate recommendations for the problem and confidence scores for the recommendations. The device may process the recommendations and the confidence scores, with an NLG model, to generate a solution to the problem and content for the solution, and may generate a digitized dynamic client solution to the problem based on the solution and the content. The device may provide the digitized dynamic client solution to a user device, and may receive feedback on the digitized dynamic client solution from the user device. The device may generate a final digitized dynamic client solution based on the feedback, and may perform actions based on the final digitized dynamic client solution.

Abstract: The present disclosure relates to the use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea or 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea, or a pharmaceutically acceptable salt thereof, in combination with a MAPKAP kinase inhibitor for the treatment of cancers, including c-KIT-mediated cancers, such as GIST.

Abstract: The present disclosure relates to the use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea or 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea, or a pharmaceutically acceptable salt thereof, in combination with a MAPKAP pathway inhibitor such as for example a RAS, RAF, MEK, or ERK inhibitor for the treatment of mastocytosis.

Abstract: An intelligent system and method detects and informs operators of unstable vehicle conditions. An accelerometer and gyro based micro-controller system dynamically computing the center of mass, speeds, positions, angles, stability factors, Velocity-Road Roughness Index, Dynamic Stability Function, and other parameters critical in determining the dynamics of vehicle motion. The apparatus may be integrated into an overall vehicle network and may incorporate a method for detecting and warning vehicle operators of unstable driving conditions which may include rollover, high velocity turns, sideslope conditions, rough roads, slip, and other dynamic events.

Abstract: An intelligent system and method detects and prevents vehicle rollover conditions. An accelerator determines vehicle speed and lateral G force, a processor computes the center of mass of the vehicle by correlating the lateral G force produced while the vehicle is turning, and an alert that is activated if the speed is exceeded or if the turn radius is reduced beyond safety limits indicative of potential rollover of the vehicle. The preferred embodiment further includes a gyroscope operative to sense lateral yaw rate excursions of the vehicle, enabling the processor to correlate the yaw rate excursions at a given speed with the lateral G forces produced while the vehicle is turning. The accelerator may further be operative to determine vertical acceleration at a given speed along a third axis, and augment rollover alarm conditions on rough road surfaces.