Patents by Inventor Anuj Goel
Anuj Goel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230342690Abstract: Methods, computing systems, and non-transitory computer-readable media are disclosed for automating and tracking loading and management of data into a data ecosystem. Data is ingested into the data ecosystem. The ingested data is standardized to generate standardized data and metadata for storage and display. The standardized data is quality controlled to produce quality controlled standardized data. The quality controlled standardized data is approved. Progress of the ingesting, the standardizing, the quality controlling, and the approving is displayed on a Kanban board.Type: ApplicationFiled: September 16, 2021Publication date: October 26, 2023Inventors: Jamie CRUISE, Andrew MACGREGOR, Fernando Nahu CANTERA RUBIO, Anuj GOEL
-
Publication number: 20220356487Abstract: An expression vector for mammalian cells includes a selection cassette with a nucleotide sequence encoding a glutamine synthetase, operably linked to a PGK promoter and a pA signal. The vector may include the EASE element which is known to promote stable integration of the expression cassettes into the genome. The vector also includes a selection cassette with a nucleotide sequence encoding an enzyme that confers resistance against an antibiotic to a bacterial host as a bacterial selection marker, operably linked to a suitable promoter. The vector further includes an expression cassette for a target polypeptide with an insertion site for a nucleotide sequence encoding the target polypeptide, operably linked to a. CMV promoter and a pA signal. The vector also includes a bacterial origin of replication.Type: ApplicationFiled: May 25, 2020Publication date: November 10, 2022Inventors: NAGARAJA GOVINDAPPA, GARIMA MISHRA, P. VENGATAPRIYA, SHERENE MATHAI, ANUJ GOEL
-
Patent number: 9670519Abstract: The present disclosure relates to methods of decreasing lactate production in cell culture using divalent transitional metallic salts. The present disclosure also relates to a method of producing polypeptide by adding divalent transitional metallic salt to the cell culture medium for reducing lactate accumulation followed by fermenting and recovering the polypeptide.Type: GrantFiled: April 27, 2012Date of Patent: June 6, 2017Assignee: Biocon LimitedInventors: Ruchika Srivastava, Sneha Lakshmandas Hemdev, Ankur Bhatnagar, Saravanan Desan, Anuj Goel, Harish Iyer, Vana Raja, Lavanya Rao
-
Patent number: 9631216Abstract: The present disclosure relates to a method of reducing heterogeneity in antibodies during culturing, wherein the heterogeneity is due to proportion of charge variant of the antibody. The disclosure also comprises a process of growing cells in a cell culture system that results in antibodies with the reduced heterogeneity. In one embodiment antibody heterogeneity is reduced by the addition of divalent transitional metal ions such as zinc (Zn2+) to the cell culture medium. In another embodiment antibody heterogeneity is reduced by decreasing the osmolality of the cell culture medium.Type: GrantFiled: April 27, 2012Date of Patent: April 25, 2017Assignee: Biocon Research LimitedInventors: Ruchika Srivastava, Sneha Lakshmandas Hemdev, Ankur Bhatnagar, Saravanan Desan, Anuj Goel, Harish Iyer
-
Patent number: 9255285Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogs, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.Type: GrantFiled: January 23, 2014Date of Patent: February 9, 2016Assignee: Biocon LimitedInventors: Sanjay Tiwari, Mukesh Babuappa Patale, Saurabh Garg, Mayank Kumar Garg, Sulekha Joshi, Chittnalli Ramegowda Naveen Kumar, Bimal Kumar, Anuj Goel, Harish Iyer
-
Patent number: 8927256Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.Type: GrantFiled: February 5, 2009Date of Patent: January 6, 2015Assignee: Biocon LimitedInventors: Sanjay Tiwari, Mukesh Babuappa Patale, Saurabh Garg, Mayank Kumar Garg, Sulekha Joshi, Chittnalli Ramegowda Naveen Kumar, Bimal Kumar, Anuj Goel, Harish Iyer
-
Patent number: 8802816Abstract: The invention relates to methods of separation and/or purification of impurities yielding a purified heterologous protein product devoid of related impurities or with substantially minimal quantities of such glycosylated impurities. More specifically, the invention relates to the identification of glycosylated forms of insulin analogues such as glargine impurities characterized post expression in yeast based systems such as Pichia pastoris. The invention also relates to methods used to clone gene encoding the protein insulin glargine; inserting the related gene in a suitable yeast host; producing culture of the recombinant strain, stimulating expression of the heterologous polypeptide, its secretion and purification post fermentation and related enzymatic conversions.Type: GrantFiled: April 3, 2008Date of Patent: August 12, 2014Assignee: Biocon LimitedInventors: Partha Hazra, Nitesh Dave, Vivekanandan Kannan, Sanjay Tiwari, Anuj Goel, Harish Iyer, Nita Roy, Krishnamurthy Venkatesan, Anoop Vasudevan, Anupama Jagadish, Goldy Sachdev, Mukesh Babuappa Patale
-
Publication number: 20140199729Abstract: The present disclosure relates to a method of reducing heterogeneity in antibodies during culturing, wherein the heterogeneity is due to proportion of charge variant of the antibody. The disclosure also comprises a process of growing cells in a cell culture system that results in antibodies with the reduced heterogeneity. In one embodiment antibody heterogeneity is reduced by the addition of divalent transitional metal ions such as zinc (Zn2+) to the cell culture medium. In another embodiment antibody heterogeneity is reduced by decreasing the osmolality of the cell culture medium.Type: ApplicationFiled: April 27, 2012Publication date: July 17, 2014Applicant: Biocon Research LimitedInventors: Ruchika Srivastava, Sneha Lakshmandas Hemdev, Ankur Bhatnagar, Saravanan Desan, Anuj Goel, Harish Iyer
-
Publication number: 20140141467Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.Type: ApplicationFiled: January 23, 2014Publication date: May 22, 2014Applicant: Biocon LimitedInventors: Sanjay Tiwari, Mukesh Babuappa Patale, Saurabh Garg, Mayank Kumar Garg, Sulekha Joshi, Chittnalli Ramegowda Naveen Kumar, Bimal Kumar, Anuj Goel, Harish Iyer
-
Publication number: 20140051124Abstract: The present disclosure relates to methods of decreasing lactate production in cell culture using divalent transitional metallic salts. The present disclosure also relates to a method of producing polypeptide by adding divalent transitional metallic salt to the cell culture medium for reducing lactate accumulation followed by fermenting and recovering the polypeptide.Type: ApplicationFiled: April 27, 2012Publication date: February 20, 2014Inventors: Ruchika Srivastava, Sneha Lakshmandas Hemdev, Ankur Bhatnagar, Saravanan Desan, Anuj Goel, Harish Iyer, Vana Raja, Lavanya Rao
-
Patent number: 8501444Abstract: The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, preferably oleic acid and/or its derivatives is employed during said process resulting in an improved yield co-efficient, productivity further providing ease of operation.Type: GrantFiled: May 22, 2008Date of Patent: August 6, 2013Assignee: Biocon LimitedInventors: Sanjay Tiwari, Chittnalli Ramegowda Naveen Kumar, Deepthy Sathyanathan, Anuj Goel, Harish Iyer
-
Patent number: 8058391Abstract: The invention claims a process for making an insulin-oligomer conjugate IN-105. IN-105 precursor having formula G-A-V-R-[B-Chain]-R-D-A-D-D-R-[A-Chain] is cloned and expressed in Pichia. The biosynthetic precursor is then conjugated with an activated oligomer. The IN-105 precursor-oligomer conjugate is then treated with protease and purified to afford active insulin-oligomer conjugate of formula insulin-OC—CH2—CH2—(OCH2CH2)3—OCH3.Type: GrantFiled: October 13, 2005Date of Patent: November 15, 2011Assignee: Biocon LimitedInventors: Nitesh Dave, Partha Hazra, Anuj Goel, Nita Roy, Anand Khedkar, Harish Iyer, Gautam Krishnan, H. S. Manjunath, Shrikumar Suryanarayan, Govindasamy Manikam, Goldy Sachdev, Mayank Garg
-
Publication number: 20110236925Abstract: The invention relates to methods of separation and/or purification of impurities yielding a purified heterologous protein product devoid of related impurities or with substantially minimal quantities of such glycosylated impurities. More specifically, the invention relates to the identification of glycosylated forms of insulin analogues such as glargine impurities characterized post expression in yeast based systems such as Pichia pastoris. The invention also relates to methods used to clone gene encoding the protein insulin glargine; inserting the related gene in a suitable yeast host; producing culture of the recombinant strain, stimulating expression of the heterologous polypeptide, its secretion and purification post fermentation and related enzymatic conversions.Type: ApplicationFiled: April 3, 2008Publication date: September 29, 2011Applicant: BIOCON LIMITEDInventors: Partha Hazra, Nitesh Dave, Vivekanandan Kannan, Sanjay Tiwari, Anuj Goel, Harish Iyer, Nita Roy, Krishnamurthy Venkatesan, Anoop Vasudevan, Anupama Jagadish, Goldy Sachdev, Mukesh, Babuappa Patale
-
Publication number: 20110020871Abstract: The invention claims a process for making an insulin-oligomer conjugate IN-105. IN-105 precursor having formula G-A-V-R-[B-Chain]-R-D-A-D-D-R-[A-Chain] is cloned and expressed in Pichia. The biosynthetic precursor is then conjugated with an activated oligomer. The IN-105 precursor-oligomer conjugate is then treated with protease and purified to afford active insulin-oligomer conjugate of formula insulin-OC—CH2—CH2—(OCH2CH2)3—OCH3.Type: ApplicationFiled: October 13, 2005Publication date: January 27, 2011Applicant: BIOCAN LIMITEDInventors: Nitesh Dave, Partha Hazra, Anuj Goel, Nita Roy, Anand Khedkar, Harish Iyer, Gautam Krishnan, H.S. Manjunath, Shrikumar Suryanarayan, Govindasamy Manikam, Goldy Sachdev, Mayank Garg
-
Publication number: 20110014664Abstract: The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, preferably oleic acid and/or its derivatives is employed during said process resulting in an improved yield co-efficient, productivity further providing ease of operation.Type: ApplicationFiled: May 22, 2008Publication date: January 20, 2011Inventors: Sanjay Tiwari, Chittnalli Ramegowda Naveen Kumar, Deepthy Sathyanathan, Anuj Goel, Harish Iyer
-
Publication number: 20100317056Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.Type: ApplicationFiled: February 5, 2009Publication date: December 16, 2010Applicant: BIOCON LIMITEDInventors: Sanjay Tiwari, Mukesh Babuappa Patale, Saurabh Garg, Mayank Kumar Garg, Sulekha Joshi, Chittnalli Ramegowda Naveen Kumar, Bimal Kumar, Anuj Goel, Harish Iyer
-
Publication number: 20090165015Abstract: A solution for managing dependencies among multiple applications is disclosed. A method may comprise: receiving dependency information of each application; receiving state information of a first application of the multiple applications; determining a state transition for a second different application of the multiple applications based on the dependency information and the state information; and outputting the determined state transition information to manage the second different application.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Applicant: SCHLUMBERGER TECHNOLOGY CORPORATIONInventor: Anuj Goel
-
Patent number: 7189558Abstract: In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens.Type: GrantFiled: September 27, 2001Date of Patent: March 13, 2007Assignee: Biocon LimitedInventors: Ramavana Gururaja, Anuj Goel, Madhavan Sridharan, Ramakrishnan Sadhana Melarkode, Madhav Kulkarni, Acharya Poornaprajna, Deepthy Sathyanathan, Sambasivam Ganesh, Shrikumar Suryanarayan
-
Publication number: 20040209335Abstract: In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens.Type: ApplicationFiled: February 4, 2004Publication date: October 21, 2004Inventors: Ramavana Gururaja, Anuj Goel, Madhavan Sridharan, Ramakrishnan Sadhana Melarkode, Madhav Kulkarni, Acharya Poornaprajna, Deepthy Sathyanathan, Sambasivam Ganesh, Shrikumar Suryanarayan