Patents by Inventor Anupa Menjoge

Anupa Menjoge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170028075
    Abstract: Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the PAMAM dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel is formed as small crosslinked particles in the size range 25 nm to 10 ?m and is suitable for injectable delivery of hydrogel or ocular delivery for the purpose of therapeutic treatment and imaging.
    Type: Application
    Filed: September 27, 2016
    Publication date: February 2, 2017
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra Navath, Anupa Menjoge
  • Patent number: 9526794
    Abstract: The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: December 27, 2016
    Assignees: Wayne State University, National Institutes of Health
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra Navath, Anupa Menjoge
  • Patent number: 9517201
    Abstract: Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: December 13, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Hilliard Kutscher, Manjeet Deshmukh, Anupa Menjoge, Yashveer Singh, Simi Gunaseelan
  • Publication number: 20140086975
    Abstract: Formulations of cross-linkable polymers, capable of forming non-toxic and biocompatible hydrogels in situ, containing at least one of doxycycline or minocycline. Methods of using the hydrogels for treating the skin or ocular tissues of mammals exposed to vesicant compounds such as sulfur mustard (SM), nitrogen mustard (NM) or half mustard (2-chloroethyl ethyl sulfide (CEES)) are also disclosed.
    Type: Application
    Filed: October 21, 2010
    Publication date: March 27, 2014
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Manjeet Deshmukh, SivaNaga S. Anumolu, Anupa Menjoge, Marion Gordon
  • Publication number: 20130136697
    Abstract: The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms.
    Type: Application
    Filed: March 31, 2011
    Publication date: May 30, 2013
    Applicants: NATIONAL INSTITUTES OF HEALTH, WAYNE STATE UNIVERSITY
    Inventors: Rangaramanujam M. Kannan, Sujatha Kannan, Roberto Romero, Raghavendra Navath, Anupa Menjoge
  • Publication number: 20110117024
    Abstract: Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.
    Type: Application
    Filed: April 6, 2009
    Publication date: May 19, 2011
    Applicant: RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Hilliard Kutscher, Manjeet Deshmukh, Anupa Menjoge, Yashveer Singh, Simi Gunaseelan
  • Publication number: 20060141053
    Abstract: The present invention discloses compositions, comprising a lipid-polymer matrix to mask the bitter or unpleasant taste of the medicament. The lipid or a blend of lipids, are used in combination with the pH dependent polymer where the said polymer is acid soluble or swellable The process for the preparation of taste masked pharmaceutical compositions of the bitter drugs comprising the said lipid-polymer compositions are disclosed. The concomitant use of the acid soluble polymer, which remains collapsed at the pH of saliva, inhibits the release of drug at that pH and hence they further help in bitterness inhibition. The said compositions deliver substantial amount of the bitter drug immediately at the gastric pH with improved palatability.
    Type: Application
    Filed: December 23, 2004
    Publication date: June 29, 2006
    Applicant: Council of Scientific and Industrial Research
    Inventors: Anupa Menjoge, Mohan Kulkarni
  • Publication number: 20060134054
    Abstract: The present invention relates a novel pH sensitive polymer which exhibits pH dependant swelling/dissolution behavior. The composition is useful for taste masking of bitter drugs and also for the gastric delivery of the drugs. The said polymer comprises a hydrophobic monomer polymerized along with a basic monomer or a hydrophobic monomer polymerized along with a basic monomer and a hydrophilic monomer.
    Type: Application
    Filed: February 15, 2006
    Publication date: June 22, 2006
    Applicant: Council of Scientific and Industrial Research
    Inventors: Mohan Kulkarni, Anupa Menjoge
  • Publication number: 20050281874
    Abstract: The present invention discloses coating compositions with taste masking property, comprising a blend of pH sensitive polymers and optionally a pH independent polymer or a blend of the pH sensitive polymer and pH independent polymer used for taste masking of highly bitter drugs. The pH sensitive polymers used comprise the acid soluble polymers and the enteric polymers. The process for the preparation of taste masked pharmaceutical compositions of the bitter drugs comprising the said coating compositions is disclosed. The concomitant use of the polymers inhibits the release of the bitter drug at the pH of saliva. The said coating compositions deliver substantial amount of the bitter drug immediately with improved palatability.
    Type: Application
    Filed: June 21, 2004
    Publication date: December 22, 2005
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Anupa Menjoge, Mohan Kulkarni
  • Publication number: 20050136115
    Abstract: The present invention discloses a substantially amorphous pharmaceutical composition comprising a drug that can exist in a variety of polymorphic forms and a pH sensitive polymer, which inhibits the crystallization of the drug during formulation and reconstitution. Polymers of higher molecular weight are more effective at lower loading, especially when the drug polymer matrix is prepared by the solvent evaporation or solvent extraction technique. The compositions used as dry syrups maintain bioavailability of the drug and effectively mask the taste of the drug when the composition is reconstituted.
    Type: Application
    Filed: December 19, 2003
    Publication date: June 23, 2005
    Applicant: Council of Scientific and Industrial Research
    Inventors: Mohan Kulkarni, Anupa Menjoge
  • Publication number: 20050137372
    Abstract: The present invention relates a novel pH sensitive polymer which exhibits pH dependant swelling/dissolution behavior. The composition is useful for taste masking of bitter drugs and also for the gastric delivery of the drugs. The said polymer comprises a hydrophobic monomer polymerized along with a basic monomer or a hydrophobic monomer polymerized along with a basic monomer and a hydrophilic monomer.
    Type: Application
    Filed: December 19, 2003
    Publication date: June 23, 2005
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Mohan Kulkarni, Anupa Menjoge
  • Publication number: 20050136114
    Abstract: The present invention discloses pharmaceutical compositions comprising of pH sensitive polymers used for taste masking highly bitter drugs. The pH sensitive polymer acts as a reverse enteric coating, which is soluble in the acidic pH range 1.0 to 3.0 normally found in the stomach but is insoluble in the pH range 3.5 to 7 thus inhibiting the release of the bitter drug at the pH of saliva and also at the pH of reconstitution medium in case of liquid orals.
    Type: Application
    Filed: December 19, 2003
    Publication date: June 23, 2005
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Mohan Kulkarni, Anupa Menjoge