Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Aggregates useful in building materials such as concrete are described. The aggregates may include fly ash and an inorganic polymer binder, which may be present as an outer layer on a core of fly ash. Methods of preparing the aggregates and concrete mixtures comprising the aggregates are also described. For example, the aggregates may be prepared by contacting fly ash agglomerates with an alkaline solution. The concrete mixtures may comprise the aggregates and a hydraulic cement.

Abstract: Gateway and bridge devices for internet of things systems are described. The gateway device is configured to communicate with a server using signals encrypted according to a first encryption protocol and to communicate with bridge device using signals encrypted with a second protocol. The bridge device is configured to decrypt the signals received from the gateway device and to communicate with sensors and actuators. The bridge device is further configured to encrypt data signals from the sensors for sending to the gateway device.

Abstract: A method for providing stateful proxying is disclosed, comprising: associating a first base station with a first base station identifier at a signaling protocol gateway, and with a first Internet Protocol (IP) address of the signaling protocol gateway; associating a second base station with a second base station identifier at the signaling protocol gateway, and with a second IP address of the signaling protocol gateway; establishing a first signaling protocol connection between a third base station and the first base station via the signaling protocol gateway with the first base station using the first IP address of the signaling protocol gateway; and establishing a signaling protocol connection between the third base station and the second base station with the second base station using the second IP address of the signaling protocol gateway.

Abstract: Methods, systems and kits are described herein for detecting the results of an assay. In particular, the methods, systems and devices of the present disclosure rely on a difference between the diffusion rates of a reporter molecule and an analyte of interest in order to quantify an amount of analyte in a microfluidic device. The analyte may be a secreted product of a biological micro-object.

Abstract: A method for performing a health check of a customized function across multiple cloud/hybrid platforms is disclosed. The method includes submitting a customized function to a health check system, which includes components on both on an on-premise network and a public cloud network. The submitted function is then uploaded to a cloud object storage. The method further includes having the customized function retrieved from the cloud object storage and scheduling an execution of the customized function according to a user defined schedule. Once the customized function is executed, the method further acquires results of the executed function and corresponding metrics and updates a health check metrics table of a metadata database with the acquired results and metrics.

Abstract: In some implementations, a first network device may transmit data to a second network device based on the data being associated with a media access control (MAC) address that is associated with an access port of the second network device, wherein the first network device and the second network device are included in a plurality of network devices interconnected by first tunnels associated with a forwarding plane and second tunnels associated with a control plane. The first network device may determine that the MAC address is associated with an access port of the first network device and may transmit, via one or more first tunnels, a notification indicating that the MAC address is associated with the first network device. The first network device may transmit, via one or more second tunnels, a notification indicating that the MAC address is associated with the first network device.

Abstract: The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.

Abstract: Various arrangements are presented for training and using a machine learning model. A first training data set may be created that has more samples but fewer dimensions than a second dataset. A second set of training data, created from the second dataset, has at least one additional dimension of data than the first set of training data. An additional dimension of data can then be simulated for the first set of training data. The simulated additional dimension of data can be incorporated with the first set of training data. A first machine learning model can be trained based on the first set of training data that comprises the simulated additional dimension of data to obtain various weights. A second machine learning model can then be trained based on the second set of training data and the obtained plurality of weights from the first trained machine learning model.

Abstract: Systems and methods for moving, reconciling, and aggregating data from mainframe computers to hybrid cloud are disclosed.

Abstract: Jewelry with non-precious metallic core and process for producing, comprising an outer layer (10) and an inner core (50), a melting temperature of the inner core (50) is higher than that of the outer layer (10), consequent to a synchronous position of an outer markers (12a, 12b, 12c) and an inner markers (52a, 52b, 52c), the outer layer (10) engulfs the inner core (50) with a prescribed thickness dimension (44) all around; mechanically moving, flexing and load bearing part of an active jewelry are made of non-precious metal, the outer layer (10) is made of a precious metal like gold, silver, platinum and the like; while the inner core (50) is made of a non-precious metal like steel, titanium and the like, the jewelry article (100) is studded with diamonds and precious stones. The jewelry article (100) may be an array of closed links (110).

Abstract: A data packet for delivery to a user equipment can be inspected. Based on the inspecting, whether to use a robust downlink delivery can be determined. Based on the determining, a robust modulation coding scheme (MCS) for the data packet can be selected. The data packet can be transmitted utilizing the selected robust MCS. At least one of the inspecting, the determining, the selecting, and the transmitting is performed using at least one processor of at least one computing system. Related apparatus, systems, techniques, and articles are also described.

Abstract: Method embodiments are disclosed for treating retinal degeneration in a subject in need thereof. In some embodiments, the method comprises administering to the subject a therapeutically effective amount of compound, and/or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, or tautomer thereof, selected from 3-(dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol hydrochloride or a compound having a structure according to a formula selected from Formula I, II, or III, as described herein. In some non-limiting examples, the subject has retinitis pigmentosa, LCA, Stargardt’s macular dystrophy, cone-rod dystrophy, choroideremia or age-related macular degeneration.

Abstract: Various methods, apparatuses/systems, and media for integrating incompatible open identity connect (OIDC) implementations are disclosed. A processor creates a custom protocol within an API gateway that understands data coming in from the aIDC protocol; receives data from the OIDC protocol; and determines, based on analyzing the data received from the aIDC protocol, any communication gap between an application and an identity layer, wherein the API gateway is implemented between the application and the identity layer. The processor then converts, in response to determining a communication gap, the data received from the aIDC protocol into a formatted data that is understandable by the application; transmits the formatted data to the application; and automatically eliminates any communication gap between the application and the identity layer based on the received formatted data.

Abstract: A system and method configures permission settings for applications (“apps”) running on a computing device of a user. A data center generates at least one model of collective privacy preferences. The computing device is in communication with the data center via a communications network. The computing device comprises a processor that execute at least a first app that requests access to at least one permission of the computing device and a personal privacy assistant app. The personal privacy assistant app receives the at least one model from the one or more servers of the data center; collects information about the user; identifies at least one recommended permission setting for the first app based on the at least one model and such that the recommended permission setting is user-specific; and configures the computing device to implement the received at least one user-specific recommended permission setting.

Abstract: Compositions and methods for rapid and efficient Toehold mediated strand displacement (TMSD) reactions are disclosed.

Abstract: Present disclosure describes the method and system for detecting the brain condition state of a subject. Method comprising calibrating a power zone of the system in real-time and detecting a reflected signal for each of a plurality of transmitted input signals on scanning each of lobe locations of the subject after calibration. Thereafter, method comprising validating an array generated using the plurality of transmitted input signal and corresponding reflected signal for each of the lobe locations and generating a lobe fit value for the validated array using a curve fitting technique. Subsequently, method comprising computing logarithmic ratios corresponding to four pairs of contralateral lobe location, six pairs of ipsilateral lobe locations in left hemisphere and six pairs of ipsilateral lobe locations in right hemisphere using the lobe fit value and classifying the logarithmic ratios into one of brain condition state classes by comparing with pre-labelled logarithmic ratios stored in system.

Abstract: A system and method for joining dissimilar metals. In one embodiment, a method comprises providing a first metal plate, a second metal plate, and an intermediate body that is positioned between the first metal plate and the second metal plate. The first metal plate is then driven into the intermediate body, which causes at least a portion of the intermediate body to collide with the second metal plate. As a result, the material of the intermediate body joins the first metal plate to the second plate. In another embodiment, a method for joining dissimilar metals comprises providing a first metal that is not amenable to welding, a second metal that is joinable to the first metal, and an intermediate body that is not joinable to at least the first metal. The intermediate body may have at least one hole such that the first metal and the second metal are positioned over and on opposite sides of the hole(s). At least a portion of the second metal may then be driven into the hole(s) to be joined to first metal.

Abstract: There are provided systems and methods for a shared prediction engine for machine learning model deployment. A service provider may provide AI hosting platforms that allow for clients, customers, and other end users to upload AI models for execution, such as machine learning models. A user may utilize one or more user interfaces provided to a client device by the service provider to select machine learning models to perform predictive services based on input features provided in an input string. Thereafter, a machine learning engine may host and execute the models during an instance of the engine provided to the client device. The engine may then process the input features in a processing thread remotely from the client device during the instance so that machine learning predictions may be determined. Thereafter, an output string for the predictions and model explanations may be provided to the client device.

Abstract: According to one embodiment, an imprint lithography template comprises a substrate transparent to ultraviolet light. A first mesa region is on the substrate. A surface of the first mesa region includes a pattern region to be pressed into a photocurable resist film. The pattern region having four sides. A second mesa region is also on the substrate. The first mesa region protrudes from a surface of the second mesa region. A blocking film is adjacent to two sides of the four sides pattern region. The two sides to which the blocking film is adjacent are connected to each other at a corner of the pattern region. The blocking film blocks ultraviolet light.