Abstract: Multi-modal, portable, handheld devices for tissue assessment (e.g., wound assessment) are provided, as are methods of fabricating and methods of using the same. The devices can be used for virtual medicine (VM)-based wound management, such as VM-based diabetic foot triage (DFT) and management. The device can be used to take physiological measurements of temperature and/or tissue oxygenation of a wound to assess the wound, for example in a remote setting environment. The device can also be used to provide therapy for tissue repair and/or wound healing, apart from the multi-modal imaging of the tissue surface of the patient. For example, light therapy, such as low-level light therapy (LLLT) can be provided via one or more light emitting diodes (LEDs) and/or laser diodes.

Abstract: A cellphone-based oxygenation tool can include a circuitry housing unit, a light emitting diode (LED) box disposed on the circuitry housing unit, a plurality of LEDs disposed in the LED box, a diffuser sheet or lens disposed on the LED box, a lens holder disposed on the circuitry housing unit and configured to be movable with respect to the circuitry housing unit, a near-infrared (NIR) filter disposed on the lens holder, and a cellphone disposed on the circuitry housing unit and having an NIR sensitive camera. Each of the plurality of LEDs can have different wavelengths, and application software of the cellphone can be configured to acquire data from the NIR sensitive camera and process the data before storing the data.

Abstract: The present application describes techniques to image biological tissue to determine biological information of an imaged tissue sample such as changes in hemoglobin concentrations, blood flow rate (pulse), and/or spatio-temporal features. Embodiments include illuminating the tissue sample with light in the near-infrared (NIR) spectrum, which is minimally absorbed but scattered through the tissue sample. By detecting the NIR light that is attenuated through, transmitted through, and/or reflected off the tissue to be imaged, the resulting NIR intensity signals may be further analyzed to provide this data. Embodiments include using multiple NIR light sources having varying wavelengths to obtain changes in the oxy- and deoxy-hemoglobin concentrations of the imaged tissue region. The tissue sample may be imaged over a time period, and the NIR images may be viewed statically or in real time after post-processing analyses have been performed.

Abstract: A cellphone-based oxygenation tool can include a circuitry housing unit, a light emitting diode (LED) box disposed on the circuitry housing unit, a plurality of LEDs disposed in the LED box, a diffuser sheet or lens disposed on the LED box, a lens holder disposed on the circuitry housing unit and configured to be movable with respect to the circuitry housing unit, a near-infrared (NIR) filter disposed on the lens holder, and a cellphone disposed on the circuitry housing unit and having an NIR sensitive camera. Each of the plurality of LEDs can have different wavelengths, and application software of the cellphone can be configured to acquire data from the NIR sensitive camera and process the data before storing the data.

Abstract: Systems and methods for scanning near infrared (NIR) and visible light images and creating co-registered images are provided. A system can include a visible light image capturing device, an near infrared image capturing device, a housing unit, a light source configured to emit light at multiple wavelengths, and a processor configured to use image segmentation algorithms to measure a target issue or wound, detect hemodynamic signals, and combine the visible light image and a hemodynamic image to create a single image.

Abstract: A method, apparatus, and system acquire data to create a 3D mesh representing a 3D object. The method, apparatus, and system acquire image data of the 3D object using an imaging probe that includes illumination and detection capability. A light source operates to illuminate the 3D object for reflection and/or trans-illumination imaging, and a detection assembly receives image reflection and/or trans-illumination image data. The reflectance and trans-illumination image data collected by the detection assembly are co-registered with a previously acquired 3D mesh using data from a tracking system monitoring the position of the probe, displayed in real-time, and optionally saved.

Abstract: The present application describes techniques to image biological tissue to determine biological information of an imaged tissue sample such as changes in hemoglobin concentrations, blood flow rate (pulse), and/or spatio-temporal features. Embodiments include illuminating the tissue sample with light in the near-infrared (NIR) spectrum, which is minimally absorbed but scattered through the tissue sample. By detecting the NIR light that is attenuated through, transmitted through, and/or reflected off the tissue to be imaged, the resulting NIR intensity signals may be further analyzed to provide this data. Embodiments include using multiple NIR light sources having varying wavelengths to obtain changes in the oxy- and deoxy-hemoglobin concentrations of the imaged tissue region. The tissue sample may be imaged over a time period, and the NIR images may be viewed statically or in real time after post-processing analyses have been performed.

Abstract: The present application describes techniques to image biological tissue to determine biological information of an imaged tissue sample such as changes in hemoglobin concentrations, blood flow rate (pulse), and/or spatio-temporal features. Embodiments include illuminating the tissue sample with light in the near-infrared (NIR) spectrum, which is minimally absorbed but scattered through the tissue sample. By detecting the NIR light that is attenuated through, transmitted through, and/or reflected off the tissue to be imaged, the resulting NIR intensity signals may be further analyzed to provide this data. Embodiments include using multiple NIR light sources having varying wavelengths to obtain changes in the oxy- and deoxy-hemoglobin concentrations of the imaged tissue region. The tissue sample may be imaged over a time period, and the NIR images may be viewed statically or in real time after post-processing analyses have been performed.

Abstract: Systems and methods for scanning near infrared (NIR) and visible light images and creating co-registered images are provided. A system can include a visible light image capturing device, an near infrared image capturing device, a housing unit, a light source configured to emit light at multiple wavelengths, and a processor configured to use image segmentation algorithms to measure a target issue or wound, detect hemodynamic signals, and combine the visible light image and a hemodynamic image to create a single image.

Abstract: The claimed method and system uses a hand-held based optical process to image large tissue volumes using a flexible probe head, increased data acquisition using multi-source illumination and multi-detector sensing, and tomographic reconstruction of sub-surface structures of a target object using ultrasonic tracking facilities.

Abstract: A method, apparatus, and system acquire data to create a 3D mesh representing a 3D object. The method, apparatus, and system acquire image data of the 3D object using two probes of an imaging system. The flexible probes conform to the shape of the 3D object, illuminate the object at a face of each probe head via optical fibers coupled to an illumination system, and receive at the surface of the 3D object, via optical fibers coupled to a detection system, light reflected from and/or transmitted through the 3D object. The reflectance and transillumination image data collected by the detection system are co-registered with the previously acquired 3D mesh using data from a tracking system monitoring the position of each probe, displayed in real-time, and optionally saved.

Abstract: The present application describes techniques to image biological tissue to determine biological information of an imaged tissue sample such as changes in hemoglobin concentrations, blood flow rate (pulse), and/or spatio-temporal features. Embodiments include illuminating the tissue sample with light in the near-infrared (NIR) spectrum, which is minimally absorbed but scattered through the tissue sample. By detecting the NIR light that is attenuated through, transmitted through, and/or reflected off the tissue to be imaged, the resulting NIR intensity signals may be further analyzed to provide this data. Embodiments include using multiple NIR light sources having varying wavelengths to obtain changes in the oxy- and deoxy-hemoglobin concentrations of the imaged tissue region. The tissue sample may be imaged over a time period, and the NIR images may be viewed statically or in real time after post-processing analyses have been performed.

Abstract: A method, apparatus, and system acquire data to create a 3D mesh representing a 3D object. The method, apparatus, and system acquire image data of the 3D object using an imaging probe that includes illumination and detection capability. A light source operates to illuminate the 3D object for reflection and/or trans-illumination imaging, and a detection assembly receives image reflection and/or trans-illumination image data. The reflectance and trans-illumination image data collected by the detection assembly are co-registered with a previously acquired 3D mesh using data from a tracking system monitoring the position of the probe, displayed in real-time, and optionally saved.

Abstract: A method, apparatus, and system display image data for a three-dimensional object in real-time, co-registering the image data acquired from a probe with the location on the three-dimensional object from which the image data was acquired, by tracking the position and orientation of the probe as the probe acquires the image data.

Abstract: A method, apparatus, and system acquire data to create a 3D mesh representing a 3D object. The method, apparatus, and system acquire image data of the 3D object using two probes of an imaging system. The flexible probes conform to the shape of the 3D object, illuminate the object at a face of each probe head via optical fibers coupled to an illumination system, and receive at the surface of the 3D object, via optical fibers coupled to a detection system, light reflected from and/or transmitted through the 3D object. The reflectance and transillumination image data collected by the detection system are co-registered with the previously acquired 3D mesh using data from a tracking system monitoring the position of each probe, displayed in real-time, and optionally saved.

Abstract: A method, apparatus, and system display image data for a three-dimensional object in real-time, co-registering the image data acquired from a probe with the location on the three-dimensional object from which the image data was acquired, by tracking the position and orientation of the probe as the probe acquires the image data.

Abstract: The claimed method and system uses a hand-held based optical process to image large tissue volumes using a flexible probe head, increased data acquisition using multi-source illumination and multi-detector sensing, and tomographic reconstruction of sub-surface structures of a target object using ultrasonic tracking facilities.