Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.

Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.

Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.

Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.

Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.

Abstract: Techniques are disclosed for optimizing performance of positioning measurements. In an aspect, a wireless mobile device receives a positioning measurements request indicating a plurality of cells of a cellular network to be measured by the wireless mobile device, and, for each cell of the plurality of cells having an entry in a memory of the wireless mobile device: based on an indicator indicating that previous positioning measurements for the cell are valid, retrieves the previous positioning measurements for the cell from the memory of the wireless mobile device and sends the previous positioning measurements for the cell to the location server, and, based on the indicator indicating that the previous positioning measurements for the cell are not valid, performs new positioning measurements for the cell and sends the new positioning measurements for the cell to the location server.

Abstract: Disclosed embodiments pertain to PCI planning and selection. A base station may select a PCI value from available PCI values, where the selected PCI value may be associated with a PRS frequency that is different from PRS frequencies of neighboring base stations. For example, a base station may obtain neighbor Physical layer Cell Identity (PCI) values for neighboring cells of the base station, where each neighbor PCI value may correspond to a distinct neighbor cell of the base station. The base station may receive one or more available PCI values, and, determine, based on the available PCI values and the neighbor PCI values, whether the available PCI values comprise one or more available non-colliding PCI values. A non-colliding available PCI value may then be selected as the PCI value for the cell served by the base station when the available PCI values comprise one or more available non-colliding PCI values.

Abstract: Methods and apparatuses are disclosed for recording a custom gesture command. In an aspect, at least one camera of a user device captures the custom gesture command, wherein the custom gesture command comprises a physical gesture performed by a user of the user device, a user interface of the user device receives user selection of one or more operations of the user device, and the user device maps the custom gesture command to the one or more operations of the user device.

Abstract: A user wearing headphones (e.g., to listen to music, to engage in a voice call, etc.) may speak while receiving an audio signal through the headphones, which may cause the user to produce Lombard speech. Because the Lombard effect is generally involuntary, the user may be unaware that he or she is producing Lombard speech. The Lombard speech may inconvenience proximate individuals and/or embarrass the user (e.g., in an office, in an airport, etc.). An apparatus may be configured to receive, through a microphone communicatively coupled to the apparatus, an audio signal. The apparatus may be configured to determine whether the audio signal indicates speech by a user. The apparatus may be further configured to alert the user based on the determination that the audio signal indicates Lombard speech by the user.

Abstract: Methods and apparatuses are disclosed for recording a custom gesture command. In an aspect, at least one camera of a user device captures the custom gesture command, wherein the custom gesture command comprises a physical gesture performed by a user of the user device, a user interface of the user device receives user selection of one or more operations of the user device, and the user device maps the custom gesture command to the one or more operations of the user device.

Abstract: A user wearing headphones (e.g., to listen to music, to engage in a voice call, etc.) may speak while receiving an audio signal through the headphones, which may cause the user to produce Lombard speech. Because the Lombard effect is generally involuntary, the user may be unaware that he or she is producing Lombard speech. The Lombard speech may inconvenience proximate individuals and/or embarrass the user (e.g., in an office, in an airport, etc.). An apparatus may be configured to receive, through a microphone communicatively coupled to the apparatus, an audio signal. The apparatus may be configured to determine whether the audio signal indicates speech by a user. The apparatus may be further configured to alert the user based on the determination that the audio signal indicates Lombard speech by the user.

Abstract: A user equipment (UE) may include a plurality of modems available to transmit data using different radio access technologies (RATs). For example, a UE may include a WiFi modem that allows the UE to connect to a wireless local area network (WLAN). The UE may further include a cellular modem that allows the UE to connect to a cellular network, such as a third generation (3G) network, fourth generation (4G) network, Long Term Evolution (LTE) network, LTE-Advanced (LTE-A) network, fifth generation (5G) network, and the like. The UE may select a RAT for transmission of data based on the data, an application associated with the data, or the like. The UE may then cause the data to be transmitted over the selected RAT, such as by providing the data to a transmission control protocol (TCP) stack associated with a modem for the selected RAT.

Abstract: A circuit and method for referenceless CDR with improved efficiency and jitter tolerance by using an additional loop for frequency detection. Such an improved circuit includes a frequency detector for identifying whether an initial recovered clock signal is faster or slower than the actual bit rate of the received data stream. The frequency detector provides a jitter tolerance of +/?0.5 UI and uses significantly fewer components that other conventional frequency detectors. Having fewer components, significantly less power is also consumed. In an embodiment, the FD uses only four flip-flops, two AND gates, and one delay circuit. Having fewer components also uses less die space in integrated circuits. Having high jitter tolerance and fewer components is an improvement over conventional referenceless CDR circuits.

Abstract: A circuit and method for referenceless CDR with improved efficiency and jitter tolerance by using an additional loop for frequency detection. Such an improved circuit includes a frequency detector for identifying whether an initial recovered clock signal is faster or slower than the actual bit rate of the received data stream. The frequency detector provides a jitter tolerance of +/?0.5 UI and uses significantly fewer components that other conventional frequency detectors. Having fewer components, significantly less power is also consumed. In an embodiment, the FD uses only four flip-flops, two AND gates, and one delay circuit. Having fewer components also uses less die space in integrated circuits. Having high jitter tolerance and fewer components is an improvement over conventional referenceless CDR circuits.

Abstract: An embodiment of a crystal oscillator circuit includes leakage-current compensation, transconductance enhancement, or both leakage-current compensation and transconductance enhancement. Such an oscillator circuit may draw a reduced operating current relative to a conventional oscillator circuit, and thus may be suitable for battery or other low-power applications.

Abstract: An apparatus for measuring time interval between two edges of a clock signal and includes an edge generator, a first multi-tap delay module, a second multi-tap delay module, and a multi-element phase detector. The edge generator produces a first edge at a first output node and a second selected edge at a second output node. First multi-tap delay module provides a first incremental delay at each tap to the first edge. Second multi-tap delay module provides a second incremental delay at each tap to the second selected edge. Each element of the multi-element phase detector has first and second input terminals. The first input terminal is coupled to a selected tap of the first multi-tap delay module and the second input terminal is coupled to a corresponding tap of the second multi-tap delay module. The output terminals of the multi-element phase detector provide the value of the time interval.