Abstract: A system for analyzing and prescribing content changes to achieve target readability level evaluates a readability score for a file at least at a whole document level and a sentence level based on a designated readability index; identifies one or more sentences that contribute to the file having the whole document level readability score outside a desired readability score of the readability index; provides a visual indicator for each of the identified one or more sentences; and re-evaluating the readability score for the file at the whole document level upon at least one of the identified one or more sentences being changed.

Abstract: A system can determine a priority order of storage devices for installation of an operating system on targeted storage. The system can further communicate with a target server to determine a group of storage devices accessible by the target server. The system can further identify a storage device of the group of storage devices that has a highest priority for operating system installation. The system can further determine a unique identifier of the storage device. The system can further install the operating system on the storage device using the unique identifier.

Abstract: An apparatus comprises a processing device configured to select first and second versions of a web application, to obtain first and second sets of source code files used for generating front ends of the first and second versions of the web application, and to generate first and second sets of tree structures based at least in part on the first and second sets of source code files, respectively. The processing device is also configured to identify node differences between the first and second sets of tree structures and to generate, based at least in part on the identified node differences, information characterizing differences between web elements of the first and second versions of the web application. The processing device is further configured to initiate automated action based at least in part on the generated information characterizing differences between web elements of the first and second versions of the web application.

Abstract: The present disclosure provides orthogonal chimeric cytokine receptor/orthogonal cytokine pairs and compositions and methods for modified immune cells or precursors thereof (e.g., modified T cells) comprising an orthogonal chimeric cytokine receptor (e.g., an oIL2R-IL9R chimeric receptor) and a chimeric antigen receptor (CAR) or a T cell receptor (TCR). The present disclosure further provides an oncolytic adenoviral vector comprising a nucleic acid sequence encoding an orthogonal cytokine (e.g., oIL2), as well as methods of using the modified cells and the vector for treating cancer in a subject in need thereof.

Abstract: The present invention provides, among other things, methods of treating cystic fibrosis, comprising a step of administering to a subject in need of treatment a composition comprising an mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, wherein the mRNA encoding the CFTR protein comprises a polynucleotide sequence at least 80% identical to SEQ ID NO: 1, wherein the mRNA is at a concentration of at least 0.4 mg/mL, and wherein the step of administering comprises inhalation.

Abstract: The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly for mRNA synthesized in vitro. In some embodiments, the methods comprise chromatographic methods of quantifying capping efficiency and methylation status of the caps.

Abstract: The present invention provides, among other things, methods and compositions for cancer treatment. The methods and compositions disclosed herein are particularly effective in reducing the size/volume of a tumor and inhibiting tumor growth.

Abstract: The present disclosure relates to systems, devices, and methods for integrating enterprise assets with a web experience of enterprise users. The systems, devices, and methods may receive a query from an enterprise user and may provide the query to a search engine. The systems, devices, and methods may receive search results and may enrich the search results with one or more enterprise assets related to the search results. The systems, devices, and methods may present a search webpage with the search results and the one or more enterprise assets.

Abstract: Analysis of power supply noise in simulations of a design of a circuit can use per instance dynamic voltage drops (DVD) in timing analyses so that the simulated DVD values on a per victim cell basis can accurately guide the timing analysis on each victim instead of a global DVD for all victims during the timing analysis. In one embodiment, a method can: determine, during a power analysis simulation, a representation of an energy lost, during each switching window at each output of each victim cell, at one or more power supply rails of each of the victim cells in the set of victim cells due to aggressors in the design; and provide the representation of the energy lost separately for each victim cell to a timing analysis system. The representation can be a rectangle having a width defined by a switching window of a victim's output.

Abstract: A method includes transferring a first subset of the first LEDs from a first substrate to a first backplane to form first subpixels in pixel regions, transferring a first subset of the second LEDs to a second backplane and separating the first subset of the second LEDs from a second substrate to leave first vacancies on the second substrate, forming an additional electrically conductive material on a second subset of second LEDs located on the second substrate after transferring the first subset of the second LEDs to the second backplane, positioning the second substrate over the first backplane, such that the first subpixels are disposed in the first vacancies, and transferring the second subset of the second LEDs to a second subset of bonding structures on the first backplane to form second subpixels in the pixel regions, while a gap exists between the first subpixels and the second substrate.

Abstract: Methods and apparatus for addressing intents using machine learning (ML) are provided. A method of operation for a node implementing ML, wherein the node instructs actions in an environment in accordance with a policy generated by a ML agent, and wherein the ML agent models the environment, includes obtaining an intent, wherein the intent specifies one or more criteria to be satisfied by the environment. The method further includes determining an intent cluster from among a plurality of intent clusters to which the intent maps, the determination being based on the criteria specified by the intent, and setting initialisation parameters for a ML model to be used to model the intent, based on the determined intent cluster. The method also includes training the ML model using training data specific to the intent, and generating one or more suggested actions to be performed on the environment using the trained ML model.

Abstract: The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from an impure preparation; (b) subjecting the impure preparation comprising precipitated mRNA to a purification process involving membrane filtration such that the precipitated mRNA is captured by a membrane; and (c) eluting the captured precipitated mRNA from the membrane by re-solubilizing the mRNA, thereby resulting in a purified mRNA solution. In some embodiments, a purification process involving membrane filtration suitable for the present invention is tangential flow filtration.

Abstract: The invention relates to a method of quantifying capping efficiency in a sample from an in vitro transcription reaction mixture comprising a plurality of mRNA transcript, characterized by a step of contacting the mRNA transcripts with an oligonucleotide complementary to a sequence of nucleotides in the 5? untranslated region of the mRNA transcripts to form an mRNA:DNA hybrid between the oligonucleotide and the sequence of nucleotides of the mRNA transcripts in order to release the first five, six, or seven nucleotides of the mRNA transcripts using nuclease (e.g., RNAse H) digestion.

Abstract: An apparatus, computer-implemented method, and system to schedule ready threads on a processor circuitry. T The apparatus includes memory circuitry, machine-readable instructions, and processor circuitry to determine a quality of a first thread of a set of threads that are ready for scheduling on the processor circuitry. Based on the quality of the first thread, the apparatus finds a set of modules of the processor circuitry that are available for scheduling. The apparatus further selects a preferred module of the set of modules for the first thread. The apparatus then schedules the first thread to run on the preferred module.

Abstract: A method of cybersecurity performance analyzing for customer site(s) including assets in a networked system including different asset types, and a virtual security engine (VSE) server. The customer site is coupled to a Security Center (SC) including a SC server, and a cybersecurity hardening compliance engine (CHCE). The VSE server collects identification data and security configuration data from the asset types, and transfers the data to a SC database. Responsive to a user request to generate a cybersecurity hardening compliance report, the CHCE sends a query to the SC database to retrieve at least a portion of the data, uploads a cybersecurity benchmark including cybersecurity configuration rules (CCRs) for least a selected asset type, compares the data of the assets to the CCRs, and generates from results of the comparing a cybersecurity report including a quantitative measure of cybersecurity performance for the assets of the selected asset type.

Abstract: A method for performing a channel state information (CSI) prediction by a user equipment (UE) is provided. The method includes receiving a plurality of reference signals from a base station, obtaining a channel quality information (CQI) estimation for an interval based on the received plurality of reference signals, wherein obtaining the CQI estimation includes obtaining at least one of mean mutual information per bit (MMIB) or effective exponential signal to noise ratio mapping (EESM), predicting the CSI based on the CQI estimation, and reporting the predicted CSI to the base station.

Abstract: The instant disclosure provides a data structure store system and a method of managing data in the store. The method includes receiving, by a data structure store management system, a request for storing data from a client. In the created data structure, each data element includes a portion of the data. On receiving a read request for at least part of the data, the data structure store management system provides at least part of the data to a recipient device. The data elements are stored in persistent memory in the form of one or more non-volatile random access devices, wherein during a time interval between receiving the storing request and providing the at least part of the data by the data structure store management system to the recipient device, the data structure store management system provides no portion of the data for writing to a hard disk drive.

Abstract: Systems, apparatuses, and methods are provided herein for network incident management. A method for network incident management comprises aggregating network metrics associated with a monitored network in a historical network data database, identifying incidents based on the network metrics, generating a training data set based on the network metrics and the incidents, wherein the training data set comprises time series of network metrics as training input and incidents as labels, training an incident model using the training data set, receiving real-time network metrics from the network via the network interface, determining an incident prediction based on the incident model using the real-time network metrics as input, and causing a user interface device to provide an alert to a user based on the incident prediction.

Abstract: A performance monitoring system (PMS 102) displays a list of example URLs that matched a URL grouping rule used to group URLs. For a rule configured for a customer of the PMS, the example matched URLs are selected by the PMS from a candidate set of URLs identified from data associated with that customer. The PMS receives information identifying a Uniform Resource Locator (URL) grouping rule displayed in a graphical user interface (GUI). The PMS identified a list of candidate URLs occurring in the stored data. The PMS then identifies, from the list of candidate URLs, a set of matched URLs, the set of matched URLs including one or more URLs from the list of candidate URLs that matched the URL grouping rule. The PMS then causes at least one URL from the set of matched URLs to be displayed on the GUI.

Abstract: The present invention provides, among other things, methods of measuring homopolymeric nucleotide lengths in a nucleic acid, including mRNA. In some aspects, provided herein is a method of measuring poly A tail length in mRNA comprising binding of mRNA with a minor-groove binding dye, followed by ribonuclease digestion and capillary electrophoresis.