Patents by Inventor Anxhela KOLE

Anxhela KOLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PURIFICATION OF CHIMERIC FVIII MOLECULES
    Publication number: 20210261607
    Abstract: The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.
    Type: Application
    Filed: January 22, 2021
    Publication date: August 26, 2021
    Inventors: Lily ZHU, Anxhela KOLE, John KULMAN, Marisol ACOSTA
  • Purification of chimeric FVIII molecules
    Patent number: 10947269
    Abstract: The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: March 16, 2021
    Assignee: Bioverativ Therapeutics Inc.
    Inventors: Lily Zhu, Anxhela Kole, John Kulman, Marisol Acosta
  • PURIFICATION OF CHIMERIC FVIII MOLECULES
    Publication number: 20160185817
    Abstract: The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.
    Type: Application
    Filed: August 8, 2014
    Publication date: June 30, 2016
    Applicant: Biogen MA Inc.
    Inventors: Lily ZHU, Anxhela KOLE, John KULMAN, Marisol ACOSTA