Abstract: A method and system are provided for acquiring the probability of slope failure and destabilization caused by an earthquake. For example, the method includes performing azimuth division in an area around a site at which a slope is located as a center, pre-setting a seismic acceleration threshold value that varies within a certain range, and calculating an exceeding probability that the seismic acceleration of the slope site generated by an earthquake in each azimuth domain is greater than or equal to the seismic acceleration threshold value, to establish an exceeding probability curve of site seismic acceleration corresponding to each azimuth domain. The method and system achieve estimation of the probability of slope destabilization caused by an earthquake by comprehensively considering the uncertainty of the seismic action and the uncertainty of slope failure and destabilization.