Patents by Inventor Aparajita Hoskote Chourasia

Aparajita Hoskote Chourasia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PDE4 DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS
    Publication number: 20240124418
    Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.
    Type: Application
    Filed: December 13, 2021
    Publication date: April 18, 2024
    Inventors: Kyle W.H. Chan, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Frank Mercurio, Robert W. Sullivan, Aparajita Hoskote Chourasia, Patrick Papa
  • SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20240025863
    Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.
    Type: Application
    Filed: September 16, 2021
    Publication date: January 25, 2024
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Imelda Lam, Patrick Papa, Angela Schoolmeesters, Eduardo Torres
  • RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20230002371
    Abstract: Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.
    Type: Application
    Filed: September 14, 2020
    Publication date: January 5, 2023
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20220298172
    Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Application
    Filed: May 30, 2022
    Publication date: September 22, 2022
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Paul E. Erdman, Aparajita Hoskote Chourasia, Leah M. Fung, David Aaron Hecht, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • Aminoamide compounds
    Patent number: 11400084
    Abstract: Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed. In addition, methods of making such compounds and their uses for treating or ameliorating diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: August 2, 2022
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Frank Mercurio, Robert W. Sullivan
  • Substituted isoindolinones
    Patent number: 11352338
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: June 7, 2022
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • BIFUNCTIONAL COMPOUNDS
    Publication number: 20220153751
    Abstract: The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 19, 2022
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Frank Mercurio, Robert W. Sullivan, Joseph P. Vacca
  • FUSED THIOPHENE COMPOUNDS
    Publication number: 20220088025
    Abstract: The present disclosure provides compounds that modulate protein function, to restore protein homeostasis, and cell-cell adhesion. The disclosure provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, are provided.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Frank Mercurio, Robert W. Sullivan
  • Bifunctional compounds
    Patent number: 11236103
    Abstract: The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: February 1, 2022
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, David Aaron Hecht, Frank Mercurio, Robert Sullivan, Joseph P. Vacca
  • Fused thiophene compounds
    Patent number: 11191769
    Abstract: The present disclosure provides compounds that modulate protein function, to restore protein homeostasis, and cell-cell adhesion. The disclosure provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, are provided.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: December 7, 2021
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Frank Mercurio, Robert Sullivan
  • AMINOAMIDE COMPOUNDS
    Publication number: 20210145812
    Abstract: Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed. In addition, methods of making such compounds and their uses for treating or ameliorating diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 20, 2021
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Frank Mercurio, Robert W. Sullivan
  • Ether compounds and uses thereof
    Patent number: 10927104
    Abstract: The present invention provides compounds that modulate protein function, to restore protein homeostasis and/or cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions of these compounds are also provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions are also provided.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: February 23, 2021
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Frank Mercurio, Aparajita Hoskote Chourasia, Leah Fung, Robert Sullivan
  • Aminoamide compounds
    Patent number: 10905684
    Abstract: Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed. In addition, methods of making such compounds and their uses for treating or ameliorating diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: February 2, 2021
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Frank Mercurio, Robert Sullivan
  • PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20200369679
    Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 26, 2020
    Inventors: Kyle W.H. Chan, Paul E. Erdman, Aparajita Hoskote Chourasia, Leah Fung, David Aaron Hecht, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • Substituted isoindolinones
    Patent number: 10844039
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: November 24, 2020
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • SUBSTITUTED ISOINDOLINONES
    Publication number: 20200325114
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 15, 2020
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • ETHER COMPOUNDS AND USES THEREOF
    Publication number: 20200231582
    Abstract: The present invention provides compounds that modulate protein function, to restore protein homeostasis and/or cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions of these compounds are also provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions are also provided.
    Type: Application
    Filed: December 18, 2019
    Publication date: July 23, 2020
    Inventors: Kyle W.H. Chan, Frank Mercurio, Aparajita Hoskote Chourasia, Leah Fung, Robert Sullivan
  • SUBSTITUTED ISOINDOLINONES
    Publication number: 20200148663
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Application
    Filed: November 12, 2019
    Publication date: May 14, 2020
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • Thienopyrimidinone compounds
    Patent number: 10584133
    Abstract: The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis. The disclosure provides methods of modulating protein-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: March 10, 2020
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • BIFUNCTIONAL COMPOUNDS
    Publication number: 20200048277
    Abstract: The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.
    Type: Application
    Filed: July 25, 2019
    Publication date: February 13, 2020
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, David Aaron Hecht, Frank Mercurio, Robert Sullivan, Joseph P. Vacca