Patents by Inventor Aparajita Madhavan

Aparajita Madhavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRE1 activating compounds for use in therapy
    Patent number: 11426402
    Abstract: Disclosed herein are compounds, their pharmaceutical salts, and pharmaceutical compositions that selectively activate the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1s) signaling pathway of the unfolded protein response (UPR), but that do not target the IRE1 kinase domain. The compounds are useful in treating diseases or conditions characterized by imbalances in proteostasis within the endoplasmic reticulum (ER) or secretory pathway, including those not associated with ER stress or activation of UPR.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: August 30, 2022
    Assignee: The Scripps Research Institute
    Inventors: R. Luke Wiseman, Jeffery W. Kelly, Julia M. D. Grandjean, Christina B. Cooley, Lars Plate, Enrique Saez, Aparajita Madhavan, Bernard Kok
  • IRE1 ACTIVATING COMPOUNDS FOR USE IN THERAPY
    Publication number: 20210008064
    Abstract: Disclosed herein are compounds, their pharmaceutical salts, and pharmaceutical compositions that selectively activate the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1s) signaling pathway of the unfolded protein response (UPR), but that do not target the IRE1 kinase domain.
    Type: Application
    Filed: May 26, 2020
    Publication date: January 14, 2021
    Inventors: R. Luke Wiseman, Jeffery W. Kelly, Julia M.D. Grandjean, Christina B, Cooley, Lars Plate, Enrique Saez, Aparajita Madhavan, Bernard Kok