Patents by Inventor Apostolos G. Doukas
Apostolos G. Doukas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115292Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: ApplicationFiled: October 10, 2023Publication date: April 11, 2024Inventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Publication number: 20240016835Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.Type: ApplicationFiled: June 30, 2023Publication date: January 18, 2024Applicant: The General Hospital CorporationInventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Patent number: 11832845Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: GrantFiled: July 6, 2020Date of Patent: December 5, 2023Assignee: The General Hospital CorporationInventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Patent number: 11730758Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.Type: GrantFiled: May 18, 2020Date of Patent: August 22, 2023Assignee: The General Hospital CorporationInventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Publication number: 20220347209Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.Type: ApplicationFiled: May 18, 2020Publication date: November 3, 2022Applicant: The General Hospital CorporationInventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Publication number: 20200384017Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.Type: ApplicationFiled: May 18, 2020Publication date: December 10, 2020Applicant: The General Hospital CorporationInventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Publication number: 20200360039Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: ApplicationFiled: July 6, 2020Publication date: November 19, 2020Inventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Patent number: 10736654Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: GrantFiled: January 16, 2018Date of Patent: August 11, 2020Assignee: The General Hospital CorporationInventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Publication number: 20180353538Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.Type: ApplicationFiled: January 3, 2018Publication date: December 13, 2018Applicant: The General Hospital CorporationInventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas, Gerard van Hamel Platerink
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Publication number: 20180140316Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: ApplicationFiled: January 16, 2018Publication date: May 24, 2018Inventors: Richard Rox ANDERSON, William A. FARINELLI, Walfre FRANCO, Joshua TAM, Fernanda H. SAKAMOTO, Apostolos G. DOUKAS, Martin PURSCHKE, Min YAO
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Patent number: 9895162Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: GrantFiled: May 14, 2015Date of Patent: February 20, 2018Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Publication number: 20180028659Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.Type: ApplicationFiled: March 15, 2017Publication date: February 1, 2018Applicant: The General Hospital CorporationInventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Publication number: 20160310527Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.Type: ApplicationFiled: November 24, 2015Publication date: October 27, 2016Inventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas, Gerard van Hamel Platerink
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Publication number: 20150238214Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: ApplicationFiled: May 14, 2015Publication date: August 27, 2015Applicant: The General Hospital CorporationInventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Publication number: 20150238776Abstract: A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue. Subsequent application of a treatment radiation can activate the photosensitizer to damage or destroy target sites while the non-target tissue remains substantially unaffected.Type: ApplicationFiled: May 8, 2015Publication date: August 27, 2015Inventors: Fernanda Hidemi Sakamoto, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Patent number: 9108045Abstract: A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue. Subsequent application of a treatment radiation can activate the photosensitizer to damage or destroy target sites while the non-target tissue remains substantially unaffected.Type: GrantFiled: December 24, 2009Date of Patent: August 18, 2015Assignee: The General Hospital CorporationInventors: Fernanda Hidemi Sakamoto, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Patent number: 9060803Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: GrantFiled: May 6, 2011Date of Patent: June 23, 2015Assignee: The General Hospital CorporationInventors: Richard A. Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Publication number: 20110313429Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.Type: ApplicationFiled: May 6, 2011Publication date: December 22, 2011Applicant: The General Hospital CorporationInventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
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Publication number: 20100174223Abstract: A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue. Subsequent application of a treatment radiation can activate the photosensitizer to damage or destroy target sites while the non-target tissue remains substantially unaffected.Type: ApplicationFiled: December 24, 2009Publication date: July 8, 2010Applicant: The General Hospital Corporation d/b/a Massachusetts General HospitalInventors: Fernanda Hidemi Sakamoto, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
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Publication number: 20090259167Abstract: The invention provides methods and compositions for treating a tissue disorder in a subject by parenterally administering a solution of aminolevulinic acid (ALA) or a derivative thereof that is not greater than 1.0 percent by weight into a local subcutaneous or dermal region of the subject; and administering high fluence light to said bodily area to produce a phototoxic species in said local region, thereby treating a tissue disorder in the subject.Type: ApplicationFiled: March 23, 2009Publication date: October 15, 2009Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Fernanda H. Sakamoto, R. R. Anderson, Zeina Tannous, William A. Farinelli, Apostolos G. Doukas