Abstract: Methods, compositions, and devices for transdermally administering an active agent such as memantine are provided.

Abstract: Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and memantine base generated in situ by reaction of a memantine salt and an alkaline salt. Compositions and kits comprising the various components, e.g., drug reservoir and/or adhesive compositions are described. Methods relating to treatment of CNS disorders, e.g., Alzheimer's disease and/or dementia, using the aforementioned transdermal delivery devices and/or compositions are also described.

Abstract: Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.

Abstract: Methods, compositions, and devices for transdermally administering an active agent such as memantine are provided.

Abstract: Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.

Abstract: Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and memantine base generated in situ by reaction of a memantine salt and an alkaline salt. Compositions and kits comprising the various components, e.g., drug reservoir and/or adhesive compositions are described. Methods relating to treatment of CNS disorders, e.g., Alzheimer's disease and/or dementia, using the aforementioned transdermal delivery devices and/or compositions are also described.

Abstract: Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.

Abstract: Compositions, devices and methods for improving the aesthetic appearance of skin are described. In one embodiment, the compositions, devices and methods reduce fine lines and/or wrinkles, and in other embodiment, the compositions, devices and methods improve skin tone by reducing regions of hyperpigmentation. The cosmetic compositions and devices described are formulated for topical application for extended wear, and comprise one or more agents to achieve the desired beneficial effect. The composition is preferably an adhesive composition that is secured to the skin for an extended time for sustained release of the one or more beneficial agents.

Abstract: Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity.

Abstract: Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity.

Abstract: This invention relates to the use of hydrophilic, biocompatible adhesives in drug delivery systems, wound dressings, bioelectrodes, and other systems in which hydrophilic, biocompatible adhesives are desirable. In particular, the invention relates to water-swellable, water-insoluble polymers that in combination render a composition adhesive upon contact with moisture, wherein a first water-swellable, water-insoluble polymer is cationic, a second water-swellable, water-insoluble polymer is anionic, and the polymers are ionically associated with each other to form a polymer matrix.

Abstract: A new tooth whitening composition provides sustained release of high levels of whitening agent and is moisture-activated without significant swelling. A preferred system for applying the composition to the teeth is flexible, self-adhesive, and well-tolerated by users. In certain embodiments the tooth whitening composition comprises a mixture of tooth whitening agents, with a first whitening agent selected so as to release peroxide gradually upon contact with moisture and produce an alkaline pH, and a second whitening agent selected so as to release peroxide rapidly upon contact with moisture.