Abstract: Systems and methods for serious illness identification and stratification are provided. In one embodiment, a method includes calculating functional scores in a plurality of categories based on healthcare data for an individual, calculating a total serious illness score for the individual based on the functional scores, measuring a serious illness score change for the individual based on the total serious illness score and historical serious illness scores for the individual, updating a clinical queue of a plurality of clinical queues to include the individual based on the serious illness score change and the total serious illness score, wherein each clinical queue comprises a list of individuals prioritized for healthcare intervention, and transmitting the updated clinical queue to a client device associated with a clinician. In this way, healthcare data may be leveraged to characterize the health status of an individual over time, and to prioritize serious illness care accordingly.