Patents by Inventor April Pawluk

April Pawluk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CRISPR COMPOUNDS AND METHODS OF USE
    Publication number: 20230167426
    Abstract: The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.
    Type: Application
    Filed: October 3, 2022
    Publication date: June 1, 2023
    Inventors: Erik Sontheimer, Alan Davidson, Karen Maxwell, April Pawluk, Yan Zhang, Jooyoung Lee, Nadia Amrani
  • Anti-CRISPR compounds and methods of use
    Patent number: 11530394
    Abstract: The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: December 20, 2022
    Assignees: UNIVERSITY OF MASSACHUSETTS, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Erik J. Sontheimer, Alan Davidson, Karen Maxwell, April Pawluk, Yan Zhang, Jooyoung Lee, Nadia Amrani