Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: Systems and methods for processing sensor data and end-of-life detection are provided. In some embodiments, a method for determining the end-of-life of a continuous analyte sensor includes receiving a sensor signal from an analyte sensor. A plurality of risk factors associated with end-of-life symptoms of analyte sensors is evaluated. The risk factors include a downward drift in sensor sensitivity over time, an amount of non-symmetrical, non-stationary noise and a duration of noise. An end-of-life status of the analyte sensor is determined based at least in part on the evaluating. An output related to the end-of-life status of the analyte sensor is provided.

Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.

Abstract: Glucose level measurements and additional data regarding a user are obtained over time, such as from a wearable glucose monitoring device being worn by the user. This additional data identifies events or conditions that may affect glucose of the user, such as physical activity engaged in by the user. A glucose prediction system analyzes, for example, activity data of the user and determines when a bout of physical activity occurs. The glucose prediction system predicts what the glucose measurements of the user would have been had the physical activity not occurred, and takes various actions based on the predicted glucose measurements (e.g., provides feedback to the user indicating what their glucose would have been had they not engaged in the physical activity).

Abstract: Glucose level measurements of a user are obtained over time, such as from a wearable glucose monitoring device being worn by the user. These glucose level measurements can be produced substantially continuously, such that the device may be configured to produce the glucose level measurements at regular or irregular intervals of time, responsive to establishing a communicative coupling with a different device, and so forth. These glucose level measurements are analyzed to detect deviations from past glucose measurements, such as glucose measurements received earlier in the day or glucose measurements received at corresponding times of one or more preceding days. Indications of detected deviations are provided to the user or communicated elsewhere, such as to a healthcare professional.

Abstract: Glucose monitoring over phases and corresponding phased information display is described. A multi-phase glucose monitoring program that includes at least a first phase and a second phase is initiated. First glucose data of a user is obtained during the first phase of the multi-phase glucose monitoring program. The output of the first glucose data in a glucose monitoring user interface is prevented during the first phase of the multi-phase glucose monitoring program. Second glucose data of the user is then obtained during a second phase of the multi-phase glucose monitoring program. The second glucose data is output, in real-time, in the glucose monitoring user interface during the second phase of the multi-phase glucose monitoring program.

Abstract: Glucose level measurements or other data regarding a user are obtained over time, such as from a wearable glucose monitoring device being worn by the user. These glucose level measurements or other data are analyzed based on various rules to determine time periods during a day of, for example, good diabetes management by the user and provide feedback indicating such to the user. Good diabetes management is identified in various manners, such as by identifying improvements in glucose measurements for a given time period over one or more previous days, identifying a time period of the day during which glucose measurements were the best, identifying sustained positive patterns (e.g., good diabetes management for a same time period in each of multiple days), and so forth.

Abstract: Glucose measurements are received and features for corresponding time periods over a time window are generated, the features being values indicating whether the user has been engaging in beneficial diabetes management behaviors. Using the aggregated features patterns indicating that beneficial diabetes management behaviors are not being engaged in are identified. Potential behavior modification feedback is generated by including in the potential behavior modification feedback at least one behavior modification feedback, for each of the identified patterns, that a user could take to engage in beneficial diabetes management behavior. At least one of the potential behavior modification feedback is selected and displayed or otherwise presented to the user.

Abstract: Feedback regarding diabetes management by a user is generated, such as feedback identifying improvements in glucose measurements for a given time period over previous days, feedback identifying sustained positive patterns, feedback identifying deviations in glucose measurements between time periods, feedback identifying potential behavior modification that a user could take to engage in beneficial diabetes management behavior, feedback identifying what a user's glucose would have been had the particular events or conditions not occurred or not been present, and so forth. A feedback presentation system analyzes the identified feedback and selects feedback based on various rankings, rules and conditions for display to the user. The selected feedback is provided to the user at various times, such as regular reports (e.g., daily or weekly reports), in real time (e.g., notifying the user what his glucose level would have been had he not just taken a walk), and so forth.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transeutaneous measurement of glucose in a host.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.