Abstract: The present invention relates to a long-acting conjugate of an interleukin-2 analog with altered binding affinity for interleukin-2 receptors.

Abstract: Provided is a composition for the treatment of osteoarthritis using iPSC-derived mitochondria. Therefore, it was confirmed that the iPSC-derived mitochondria of the present disclosure increased the transplant ability into chondrocytes, suppressed the expression of the MMP series, which were cartilage metabolic factors, and suppressed the death of chondrocytes. In addition, it was confirmed that the iPSC-derived mitochondria suppressed damage to joint tissue in an osteoarthritis animal model, reduced immune cells, and increased immune osteoarthritis-causing regulatory cells. In addition, it was confirmed that the expression of UCP2 in iPSC-derived mitochondria was significantly increased compared to mitochondria isolated from other origin cells, and that UCP2 was closely related to the treatment effect of osteoarthritis caused by mitochondrial transplantation. In addition, it was confirmed that iPSC-derived mitochondria overexpressing UCP2 improves osteoarthritis as a cartilage regeneration effect.

Abstract: A liver-targeted drug and therapeutic use thereof for diseases requiring drug action in the liver are disclosed. Additionally, a method in which a substance having activity on glucagon is used so as to induce delivery of the drug to the liver tissue or an increase in distribution of the drug in the liver tissue after in vivo administration.

Abstract: The present invention relates to a pharmaceutical composition comprising a novel compound as an active ingredient for prevention or treatment of transplant rejection. The novel compound SD911 of the present invention was identified to repress the migration of immune cells, increase the engraftment and viability of a grafted tissue, and regulate immune cells. In addition, it was found in a kidney transplantation model that the compound restrained human PBMC from suppressing the engraftment and damaging renal tissues and downregulated the expression of the inflammatory cytokine IL-17, with the consequent effective prevention and treatment of transplant rejection.

Abstract: The present invention relates to a long-acting conjugate of an interleukin-2 analog with altered binding affinity for interleukin-2 receptors.

Abstract: New therapeutic uses of a triple agonist and/or a long-acting conjugate thereof are disclosed. The triple agonist and/or a long-acting conjugate thereof acts on all of glucagon receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucose-dependent insulinotropic polypeptide (GIP) receptor, and is useful in treating neurodegenerative diseases. Thus, patients’ options can be broadened by expanding the category of drugs applicable to applicable to neurodegenerative diseases, and can increase convenience for patients by significantly increasing blood half-life.

Abstract: Provided is a use of a triple glucagon/GLP-1/GIP receptor agonist or a long-acting conjugate thereof for treatment of hyperlipidemia.

Abstract: A composition containing a glucagon derivative and a GLP-1 and GIP receptor dual agonist, and uses thereof are disclosed. The glucagon derivative comprises an amino acid sequence of the formula 1: X1-X2-QGTF-X7-SD-X10-S-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-F-X23-X24-WL-X27-X28-X29-X30 (Formula 1). The composition is useful in preventing or treating metabolic syndrome.

Abstract: Provided are a composition and a complex formulation, each including insulin or a long-acting conjugate thereof and glucagon or a long-acting conjugate thereof.

Abstract: A display device includes a lower display panel, an upper display panel facing the lower display panel, a metal oxide layer surrounding outermost surfaces of the upper display panel and the lower display panel, and a barrier layer surrounding the metal oxide layer. The barrier layer includes a self-assembled monolayer.

Abstract: A display device includes a lower display panel, an upper display panel facing the lower display panel, a metal oxide layer surrounding outermost surfaces of the upper display panel and the lower display panel, and a barrier layer surrounding the metal oxide layer. The barrier layer includes a self-assembled monolayer.

Abstract: A liquid crystal display comprises: a substrate having a plurality of pixel regions; first electrode formed on the substrate in each of the pixel regions and including a plurality of separated branch electrodes; a cover layer forming a cavity with the substrate, the cover layer including side walls formed on the substrate to partition the plurality of pixel regions and a roof formed on the side walls; a second electrode formed on a bottom surface of the cover layer; a capping layer formed in the cavity to cover the first electrode on the substrate and to cover the second electrode on the bottom surface of the roof; an alignment layer formed on the capping layer; and a liquid crystal layer formed through injection of liquid crystal molecules into the cavity.

Abstract: A display device includes a lower display panel, an upper display panel facing the lower display panel, a metal oxide layer surrounding outermost surfaces of the upper display panel and the lower display panel, and a barrier layer surrounding the metal oxide layer. The barrier layer includes a self-assembled monolayer.

Abstract: A display device and a method of manufacturing the display device are provided. Moisture may be prevented from penetrating into the display device. The display device includes a substrate including a pixel area. A thin film transistor is formed on the substrate. A pixel electrode is connected to the thin film transistor and formed in the pixel area. A roof layer is formed on the pixel electrode. The roof layer is separated from the pixel electrode via a microcavity. A liquid crystal layer fills the microcavity. A liquid crystal injection hole is formed in the roof layer and exposes a portion of the microcavity. An encapsulation layer is formed on the roof layer. The encapsulation layer covers the liquid crystal injection hole and seals the microcavity for the pixel area. The encapsulation layer includes a multilayer structure.

Abstract: A display device includes: an insulation substrate including a plurality of pixel areas; a thin film transistor provided on the insulation substrate; a pixel electrode connected to the thin film transistor; a liquid crystal layer filling a microcavity; a common electrode provided on the liquid crystal layer and separated from the pixel electrode by the microcavity; a roof layer provided on the common electrode; an injection hole formed on the common electrode and the roof layer to expose part of the microcavity; an overcoat formed on the roof layer to cover the injection hole and seal the microcavity; and a passivation layer provided on the overcoat, wherein the passivation layer includes an inorganic layers.

Abstract: A display device and a method of manufacturing the display device are provided. Moisture may be prevented from penetrating into the display device. The display device includes a substrate including a pixel area. A thin film transistor is formed on the substrate. A pixel electrode is connected to the thin film transistor and formed in the pixel area. A roof layer is formed on the pixel electrode. The roof layer is separated from the pixel electrode via a microcavity. A liquid crystal layer fills the microcavity. A liquid crystal injection hole is formed in the roof layer and exposes a portion of the microcavity. An encapsulation layer is formed on the roof layer. The encapsulation layer covers the liquid crystal injection hole and seals the microcavity for the pixel area. The encapsulation layer includes a multilayer structure.

Abstract: A liquid crystal display comprises: a substrate having a plurality of pixel regions; first electrode formed on the substrate in each of the pixel regions and including a plurality of separated branch electrodes; a cover layer forming a cavity with the substrate, the cover layer including side walls formed on the substrate to partition the plurality of pixel regions and a roof formed on the side walls; a second electrode formed on a bottom surface of the cover layer; a capping layer formed in the cavity to cover the first electrode on the substrate and to cover the second electrode on the bottom surface of the roof; an alignment layer formed on the capping layer; and a liquid crystal layer formed through injection of liquid crystal molecules into the cavity.

Abstract: A liquid crystal display includes a substrate, a thin film transistor disposed on the substrate, a pixel electrode disposed on the thin film transistor, a roof layer facing the pixel electrode, and at least one partition wall disposed along an edge of the substrate, in which a plurality of microcavities is formed between the pixel electrode and the roof layer, and the plurality of microcavities includes a liquid crystal material.

Abstract: A display device and a method of manufacturing the display device are provided. Moisture may be prevented from penetrating into the display device. The display device includes a substrate including a pixel area. A thin film transistor is formed on the substrate. A pixel electrode is connected to the thin film transistor and formed in the pixel area. A roof layer is formed on the pixel electrode. The roof layer is separated from the pixel electrode via a microcavity. A liquid crystal layer fills the microcavity. A liquid crystal injection hole is formed in the roof layer and exposes a portion of the microcavity. An encapsulation layer is formed on the roof layer. The encapsulation layer covers the liquid crystal injection hole and seals the microcavity for the pixel area. The encapsulation layer includes a multilayer structure.

Abstract: A liquid crystal dropping method and a liquid crystal display manufacturing method using the same are disclosed. The method for dropping a liquid crystal includes dropping a liquid crystal along a plurality of liquid crystal dropping routes on a display panel where a plurality of pixels are arranged in a matrix form, wherein a relative position of a first liquid crystal dropping route passing a first pixel among the plurality of pixels with respect to the first pixel, and a relative position of a second liquid crystal dropping route passing a second pixel among the plurality of pixels with respect to the second pixel, are substantially equivalent to each other.