Abstract: Techniques for compressing neural signals are disclosed herein. The neural signal compression techniques can include lossless compression, lossy compression, binned spike compression, and spike-band power compression. Lossless compression can compress neural signals using a difference predictor to encode compressed neural signals via binary and unary coding. Lossy compression can compress neural signals using quantized wavelet transforms to generate an encoded bit-stream of compressed neural signals. Binned spike and spike-band power compression can leverage the sparse nature of neural signals to threshold the neural signals for generating an appended bit-stream of compressed neural signals.