Patents by Inventor Aranapakam Mudumbai Venkatesan

Aranapakam Mudumbai Venkatesan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (2-ARYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)MORPHOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20100003250
    Abstract: The invention relates to 2-aryl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: July 2, 2009
    Publication date: January 7, 2010
    Applicant: Wyeth
    Inventors: Zecheng Chen, Aranapakam Mudumbai Venkatesan, Arie Zask, Jeroen Cunera Verheijen, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Kevin Joseph Curran
  • 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090311217
    Abstract: The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 17, 2009
    Applicant: Wyeth
    Inventors: Matthew Gregory Bursavich, Nan Zhang, Semiramis Ayral-Kaloustian, James Thomas Anderson, Thai Hiep Nguyen, Sabrina Lombardi, David Malwitz, Natasja Brooijmans, Derek Cecil Cole, Adam Matthew Gilbert, Pawel Wojciech Nowak, Kaapjoo Park, Sasmita Das, Hwei-Ru Tsou, Aranapakam Mudumbai Venkatesan, Mercy Adufa Otteng, Gary Harold Birnberg, Gloria Jean MacEwan
  • TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS
    Publication number: 20090304692
    Abstract: Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
    Type: Application
    Filed: May 22, 2009
    Publication date: December 10, 2009
    Applicant: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Zecheng Chen, Christoph Martin Dehnhardt, Osvaldo dos Santos, Efren Guillermo Delos Santos, Arie Zask, Jeroen Cunera Verheijen, Joshua Aaron Kaplan, David James Richard, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Ariamala Gopalsamy, Kevin Joseph Curran, Mengxiao Shi
  • TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS
    Publication number: 20090291079
    Abstract: Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
    Type: Application
    Filed: May 22, 2009
    Publication date: November 26, 2009
    Applicant: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Zecheng Chen, Christoph Martin Dehnhardt, Osvaldo dos Santos, Efren Guillermo Delos Santos, Arie Zask, Jeroen Cunera Verheijen, Joshua Aaron Kaplan, David James Richard, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Ariamala Gopalsamy, Kevin Joseph Curran, Mengxiao Shi
  • 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS
    Publication number: 20090227575
    Abstract: A 7H-pyrrolo[2,3-h]quinazoline compound of the formula I wherein Ar, R1, R2, R7, R8, R9, R10, R11, R12, and n are as defined in the specification, and methods for making same.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 10, 2009
    Applicant: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Zecheng Chen, Osvaldo Dos Santos, Natasja Brooijmans, Ariamala Gopalsamy
  • 1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090192176
    Abstract: The invention relates to 1H-pyrazolo[3,4-d]pyrimidine, purine, 7H-purin-8(9H)-one, 3H-[1,2,3]triazolo[4,5-d]pyrimidine, and thieno[3,2-d]pyrimidine compounds, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: January 29, 2009
    Publication date: July 30, 2009
    Applicant: Wyeth
    Inventors: Arie Zask, Christoph Martin Dehnhardt, Joshua Aaron Kaplan, Efren Guillermo Delos Santos, Aranapakam Mudumbai Venkatesan, Jeroen Cunera Verheijen
  • [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090192147
    Abstract: The invention relates to [a]-fused indole compounds of the Formula II, or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein. The invention also relates to compositions comprising the compounds of Formula II, and methods for making and using the compounds.
    Type: Application
    Filed: January 30, 2009
    Publication date: July 30, 2009
    Applicant: Wyeth
    Inventors: Semiramis Ayral-Kaloustian, Nan Zhang, Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Thai Hiep Nguyen, James Thomas Anderson
  • 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090181963
    Abstract: The invention relates to 3H-[1,2,3]triazolo[4,5-d]pyrimidine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: January 15, 2009
    Publication date: July 16, 2009
    Applicant: Wyeth
    Inventors: Christoph Martin Dehnhardt, Aranapakam Mudumbai Venkatesan, Efren Guillermo Delos Santos, Zecheng Chen, Osvaldo Dos Santos, Natasja Brooijmans, Arie Zask, Jeroen Cunera Verheijen, Semiramis Ayral-Kaloustian
  • PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS
    Publication number: 20090149458
    Abstract: A pyrrolo[3,2-d]pyrimidine compound, such as a compound of the formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: November 24, 2008
    Publication date: June 11, 2009
    Applicant: Wyeth
    Inventors: Zecheng CHEN, Aranapakam Mudumbai VENKATESAN, Semiramis Ayral-Kaloustian, Tarek Subayl Mansour, Christoph Martin Dehnhardt, Arie Zask, Jeroen Cunera Verheijen
  • BENZOFURANYL- AND BENZOTHIENYL- PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE
    Publication number: 20090054454
    Abstract: Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.
    Type: Application
    Filed: August 21, 2007
    Publication date: February 26, 2009
    Inventors: Aranapakam Mudumbai Venkatesan, Osvaldo Dos Santos, Magda Asselin, George Theodore Grosu, Deborah A. Evrard, Richard Eric Mewshaw, Kristin Meagher
  • Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
    Publication number: 20090018332
    Abstract: The invention relates to processes for the preparation of the bicyclic oxazine carboxaldehyde Compound 1: The invention also relates to the use of Compound 1 in the preparation of ?-lactamase inhibitors.
    Type: Application
    Filed: June 24, 2008
    Publication date: January 15, 2009
    Applicant: Wyeth
    Inventors: Kenneth Alfred Martin Kremer, Lalitha Krishnan, Aranapakam Mudumbai Venkatesan, Mellard Norman Jennings, Joseph Zeldis, Takao Abe, Tarek Suhayl Mansour, Henry Lee Strong
  • Tricyclic 6-Alkylidene-Penems as Beta-Lactamase Inhibitors
    Publication number: 20080318921
    Abstract: The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
    Type: Application
    Filed: August 7, 2008
    Publication date: December 25, 2008
    Applicant: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Ado Mihira, Atul Agarwal, Hideki Ushirogochi, Yansong Gu, Satoshi Tamai, Fuk-Wah Sum
  • Bicyclic 6-Alkylidene-Penems as Beta-Lactamase Inhibitors
    Publication number: 20080312203
    Abstract: The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is O, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
    Type: Application
    Filed: August 21, 2008
    Publication date: December 18, 2008
    Applicant: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Itsuki Yamamura, Tsuyoshi Takasaki, Atul Agarwal, Osvaldo Dos Santos, Fuk-Wah Sum, Yang-I Lin
  • IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS
    Publication number: 20080233127
    Abstract: The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
    Type: Application
    Filed: March 7, 2008
    Publication date: September 25, 2008
    Applicant: Wyeth
    Inventors: Matthew Gregory Bursavich, Aranapakam Mudumbai Venkatesan, Pawel Wojciech Nowak, Sabrina Lombardi, Adam Matthew Gilbert, Christoph Martin Denhardt, Osvaldo Dos Santos, Efren Guillermo Delos Santos, Natasja Brooijmans, Semiramis Ayral-Kaloustian, Zecheng Chen, Jeroen Cunera Verheijen, Joshua Kaplan, Arie Zask
  • Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
    Patent number: 7276603
    Abstract: Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Osvaldo Dos Santos, Magda Asselin, George Theodore Grosu, Deborah A. Evrard, Richard Eric Mewshaw, Kristin Meagher
  • Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
    Patent number: 7235569
    Abstract: 3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: June 26, 2007
    Assignee: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Osvaldo Dos Santos, Yansong Gu
  • 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid derivatives as ?-lactamase inhibitors
    Patent number: 7229983
    Abstract: The present invention relates to novel, low molecular weight broad spectrum compounds in particular to a class of 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid or their derivatives which have ?-lactamase inhibitory and antibacterial properties. The compounds are therefore useful in the treatment of antibacterial infections in humans or animals, either alone or in combination with other antibiotics.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: June 12, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Tarek Suhayl Mansour, Aranapakam Mudumbai Venkatesan
  • Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression
    Patent number: 7148235
    Abstract: A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing this compound and methods for treating disorders of the serotonin-affected neurological systems utilizing such a compound or composition.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: December 12, 2006
    Assignee: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Jamie M. Davis, Yansong Gu
  • Bicyclic 6-alkylidene-penems as ?-lactamase inhibitors
    Patent number: 7112582
    Abstract: The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is S.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: September 26, 2006
    Assignee: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Itsuki Yamamura, Tsuyoshi Takasaki, Atul Agarwal, Osvaldo dos Santos, Fuk-Wah Sum, Yang-I Lin
  • Tricyclic 6-alkylidene-penems as ?-lactamase inhibitors
    Patent number: 7018997
    Abstract: The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is S.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: March 28, 2006
    Assignee: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Ado Mihira, Atul Agarwal, Hideki Ushirogochi, Yansong Gu, Satoshi Tamai, Fuk-Wah Sum