Patents by Inventor Arash Grakoui

Arash Grakoui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for identifying and sorting antigen-specific B cells
    Patent number: 11739138
    Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. The present disclosure also relates to methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: August 29, 2023
    Assignees: Emory University, Rutgers, the State University of New Jersey
    Inventors: Arash Grakoui, Joseph Marcotrigiano
  • CAS9-nucleic acid complexes and uses related thereto
    Patent number: 11312945
    Abstract: This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: April 26, 2022
    Assignee: Emory University
    Inventors: David S. Weiss, Arash Grakoui, Timothy R. Sampson, Aryn Alaine Price
  • Compositions and Methods for Identifying and Sorting Antigen-Specific B Cells
    Publication number: 20220112272
    Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. The present disclosure also relates to methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.
    Type: Application
    Filed: December 21, 2021
    Publication date: April 14, 2022
    Inventors: Arash Grakoui, Joseph Marcotrigiano
  • Compositions and methods for identifying and sorting antigen-specific B cells
    Patent number: 11236153
    Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. Specifically, the disclosure provides a construct useful in expressing biotinylated antigen monomers, said construct comprising a viral protein of an ectodomain of Hepatitis C Virus (HCV) envelope glycoprotein E2 or Human Immunodeficiency Virus (HIV) gp140. Further disclosed are methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: February 1, 2022
    Assignees: Emory University, Rutgers, the State University of New Jersey
    Inventors: Arash Grakoui, Joseph Marcotrigiano
  • CAS9-NUCLEIC ACID COMPLEXES AND USES RELATED THERETO
    Publication number: 20200354700
    Abstract: This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein.
    Type: Application
    Filed: July 10, 2019
    Publication date: November 12, 2020
    Inventors: David S. Weiss, Arash Grakoui, Timothy R. Sampson, Aryn Alaine Price
  • Compositions and Methods for Identifying and Sorting Antigen-Specific B Cells
    Publication number: 20200181242
    Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. Specifically, the disclosure provides a construct useful in expressing biotinylated antigen monomers, said construct comprising a viral protein of an ectodomain of Hepatitis C Virus (HCV) envelope glycoprotein E2 or Human Immunodeficiency Virus (HIV) gp140. Further disclosed are methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.
    Type: Application
    Filed: September 22, 2017
    Publication date: June 11, 2020
    Inventors: Arash Grakoui, Joseph Marcotrigiano
  • Cas9-nucleic acid complexes and uses related thereto
    Patent number: 10544405
    Abstract: This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: January 28, 2020
    Assignee: Emory University
    Inventors: David S. Weiss, Arash Grakoui, Timothy R. Sampson, Aryn Alaine Price
  • HCV E2 construct compositions and methods
    Patent number: 9758794
    Abstract: Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: September 12, 2017
    Assignees: Rutgers, The State University of New Jersey, Emory University
    Inventors: Joseph Marcotrigiano, Jillian L. Whidby, Arash Grakoui
  • Hepatitis C virus particles, vaccines, compositions and methods related thereto
    Patent number: 9512184
    Abstract: This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and administered to a subject to illicit an immune response.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: December 6, 2016
    Assignee: Emory University
    Inventor: Arash Grakoui
  • HCV E2 CONSTRUCT COMPOSITIONS AND METHODS
    Publication number: 20150368668
    Abstract: Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
    Type: Application
    Filed: May 1, 2014
    Publication date: December 24, 2015
    Applicants: Rutgers, The State University of New Jersey, Emory University School of Medicine
    Inventors: Joseph Marcotrigiano, Jillian L. Whidby, Arash Grakoui
  • CAS9-NUCLEIC ACID COMPLEXES AND USES RELATED THERETO
    Publication number: 20150353905
    Abstract: This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein.
    Type: Application
    Filed: January 15, 2014
    Publication date: December 10, 2015
    Inventors: David S. Weiss, Arash Grakoui, Timothy R. Sampson, Aryn Alaine Price
  • HEPATITIS C VIRUS PARTICLES, VACCINES, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20140105931
    Abstract: This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and administered to a subject to illicit an immune response.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 17, 2014
    Applicant: EMORY UNIVERSITY
    Inventor: Arash Grakoui