Patents by Inventor Arash Grakoul

Arash Grakoul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCV E2 CONSTRUCT COMPOSITIONS AND METHODS
    Publication number: 20110091495
    Abstract: A construct comprising the ectodomain of the Hepatitis C Virus (HCV) E2 sequence and a mammalian expression system therefor is disclosed. The construct comprises a CMV promoter, prolactin signal sequence, the ectodomain of HCV E2 sequence truncated at aa 664, a thrombin cleavage site and a human Fc domain. The method also relates to an expression system for the construct, which is stably expressed in human embryonic kidney cells 293T. Continuous protein expression in a bioreactor allows for 4 mg of purified protein per liter of cell supernatant.
    Type: Application
    Filed: April 22, 2009
    Publication date: April 21, 2011
    Inventors: Joseph Marcotrigiano, Jillian L. Whidby, Arash Grakoul