Abstract: The present disclosure provides methods and systems for predicting future disease states of a subject. An exemplary method comprises: (a) obtaining an image from an imaging device, wherein the image indicates a disease associated with the subject; (b) generating an annotation mask for a current disease state; (c) processing the image data and the annotation mask to generate a temporal sequence of images with corresponding predicted disease states; and (d) outputting the temporal sequence of images and disease analytics within a graphical user interface (GUI).