Patents by Inventor Arati K. Sharma
Arati K. Sharma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082252Abstract: Compositions and methods continue to be required for treatment of cancer. Compositions and methods according to aspects of the present invention relate to inhibition of a combination of kinases for treatment of cancer, specifically inhibition of both AKT and WEE1 kinases for treatment of cancer in a human subject. Synergistic effects of combination compositions and treatments including administration of an AKT inhibitor and a WEE1 inhibitor are unexpectedly found as described herein.Type: ApplicationFiled: November 22, 2023Publication date: March 14, 2024Inventors: Gavin R. Robertson, Raghavendragowda Gowda Chandagalu Doreswamy, Omer F. Kuzu, Arati K. Sharma, Gregory Kardos, Subbarao V. Madhunapantula, Mohammed A. Noory, Joseph J. Drabick
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Publication number: 20180325902Abstract: Compositions and methods continue to be required for treatment of cancer. Compositions and methods according to aspects of the present invention relate to inhibition of a combination of kinases for treatment of cancer, specifically inhibition of both AKT and WEE1 kinases for treatment of cancer in a human subject. Synergistic effects of combination compositions and treatments including administration of an AKT inhibitor and a WEE1 inhibitor are unexpectedly found as described herein.Type: ApplicationFiled: November 7, 2016Publication date: November 15, 2018Inventors: Gavin P. Robertson, Raghavendragowda Gowda Chandagalu Doreswamy, Omer F. Kuzu, Arati K. Sharma, Gregory Kardos, Subbarao V. Madhunapantula, Mohammed A. Noory, Joseph J. Drabick
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Patent number: 10010504Abstract: The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including celecoxib and plumbagin in combination; methods for treatment of a proliferative disease including administration of celecoxib and plumbagin in a subject in need thereof; and particularly methods for treatment of skin cancer including administration of celecoxib and plumbagin in a subject in need thereof.Type: GrantFiled: March 15, 2013Date of Patent: July 3, 2018Assignee: The Penn State Research FoundationInventors: Gavin P. Robertson, Chandagalu D. Raghavendra Gowda, Arati K. Sharma, Gregory Kardos, Sanjay Singh
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Publication number: 20160045437Abstract: The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including celecoxib and plumbagin in combination; methods for treatment of a proliferative disease including administration of celecoxib and plumbagin in a subject in need thereof; and particularly methods for treatment of skin cancer including administration of celecoxib and plumbagin in a subject in need thereof.Type: ApplicationFiled: March 15, 2013Publication date: February 18, 2016Inventors: Gavin P. Robertson, Chandagalu D. Raghavendra, Arati K. Sharma, Gregory Kardos, Sanjay Singh
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Publication number: 20150376124Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.Type: ApplicationFiled: June 30, 2015Publication date: December 31, 2015Inventors: Gavin P. Robertson, Arati K. Sharma, Arun K. Sharma, Shantu G. Amin, Dhimant H. Desai
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Patent number: 9126911Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.Type: GrantFiled: March 5, 2013Date of Patent: September 8, 2015Assignee: The Penn State Research FoundationInventors: Gavin P. Robertson, Arati K. Sharma, Arun K. Sharma, Shantu G. Amin, Dhimant H. Desai
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Patent number: 9126910Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.Type: GrantFiled: March 5, 2013Date of Patent: September 8, 2015Assignee: The Penn State Research FoundationInventors: Gavin P. Robertson, Arati K. Sharma, Arun K. Sharma, Shantu G. Amin, Dhimant H. Desai
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Patent number: 9096505Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.Type: GrantFiled: March 5, 2013Date of Patent: August 4, 2015Assignee: The Penn State Research FoundationInventors: Gavin P. Robertson, Arati K. Sharma, Arun K. Sharma, Shantu G. Amin, Dhimant H. Desai
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Publication number: 20140348901Abstract: The invention relates to combining targeted therapies with selected chemotherapeutics for the treatment of melanoma. The invention provides a method for inducing apoptosis in a melanoma tumor cell by reducing Akt3 activity, a method for inducing apoptosis in a melanoma tumor cell comprising contacting a melanoma tumor cell with an agent that reduces Akt3 activity to restore normal apoptotic sensitivity to a melanoma tumor cell, allowing a lower concentration of chemotherapeutic agents resulting in decreased toxicity to a patient. Also disclosed is a method for treating a melanoma comprising administering an agent that reduces Akt3 activity and an agent that reduces V599E B-Raf activity, thereby treating a melanoma tumor.Type: ApplicationFiled: April 25, 2014Publication date: November 27, 2014Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Gavin P. Robertson, Lakshman Segar, Mark Kester, Arati K. Sharma
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Publication number: 20130253052Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.Type: ApplicationFiled: March 5, 2013Publication date: September 26, 2013Applicant: The Penn State Research FoundationInventors: Gavin P. Robertson, Arati K. Sharma, Arun K. Sharma, Shantu G. Amin, Dhimant H. Desai
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Publication number: 20080306148Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.Type: ApplicationFiled: April 14, 2008Publication date: December 11, 2008Applicant: The Penn State Research FoundationInventors: Gavin P. Robertson, Arati K. Sharma, Arun K. Sharma, Shantu Amin, Dhimant Desai