Patents by Inventor Aravinda De Silva

Aravinda De Silva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR STABILIZED RECOMBINANT FLAVIVIRUS E PROTEIN DIMERS
    Publication number: 20220289796
    Abstract: The present invention provides compositions and methods of use comprising a stabilized recombinant E glycoprotein comprising a flavivirus E glycoprotein backbone, which comprises amino acid substitutions that stabilize the E glycoprotein in dimer conformation under physiological conditions.
    Type: Application
    Filed: August 6, 2020
    Publication date: September 15, 2022
    Inventors: Brian Kuhlman, Stephan T. Kudlacek, Aravinda De Silva, Alexander Payne, Thanh Phan, Stefan Metz
  • HIGHLY SPECIFIC ZIKA NEUTRALIZING HUMAN ANTIBODIES
    Publication number: 20210054055
    Abstract: Provided herein, in some embodiments, are compositions of Zika-specific antibodies and antigen-binding fragments thereof and methods of using said antibodies and antigen-binding fragments.
    Type: Application
    Filed: November 21, 2018
    Publication date: February 25, 2021
    Applicants: The University of Vermont and State Agricultural College, The University of North Carolina at Chapel Hill
    Inventors: Sean Diehl, Aravinda de Silva, Matthew Collins, Ben McElvany, Huy Tu
  • Methods and compositions for dengue virus vaccines
    Patent number: 10870682
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: December 22, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES
    Publication number: 20190225654
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: August 20, 2018
    Publication date: July 25, 2019
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • Methods and compositions for dengue virus vaccines
    Patent number: 10053493
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: August 21, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • Methods and Compositions for Dengue Virus Vaccines
    Publication number: 20160257719
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: June 26, 2014
    Publication date: September 8, 2016
    Inventors: William MESSER, Ralph BARIC, Aravinda DE SILVA, Boyd YOUNT
  • IXODES SCAPULARIS SALIVARY PROTEINS AND METHODS OF USE FOR MODULATION OF THE ALTERNATIVE COMPLEMENT PATHWAY
    Publication number: 20110014218
    Abstract: Ixodes Scapularis salivary proteins, including Ixodes Scapularis anti-complement protein (Isac) and Isac-like protein family (ILP family) proteins, biologically functional equivalents and fragments thereof, and nucleic acid molecules encoding the same are disclosed. ILP family proteins, gene products and polypeptide fragments bind to proteins with thrombospondin repeats. Thus, therapeutic methods involving modulating proteins with thrombospondin repeats using ILP family proteins and biologically active polypeptide fragments thereof are also disclosed. ILP family proteins, gene products and polypeptide fragments have biological activity in modulating the complement pathway through specific binding to properdin. Thus, therapeutic methods involving modulating the complement pathway using ILP family proteins and biologically active polypeptide fragments thereof are also disclosed.
    Type: Application
    Filed: January 26, 2009
    Publication date: January 20, 2011
    Inventors: Aravinda De Silva, Katharine Tyson, Erol Fikrig