Patents by Inventor Araz Jakalian

Araz Jakalian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lactams as CBL-B inhibitors selective over C-CBL
    Patent number: 12187709
    Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: January 7, 2025
    Assignee: Genentech, Inc.
    Inventors: Malcolm Huestis, Michael John Lambrecht, Jun Liang, Man Un Ung, Xiaojing Wang, Jason Robert Zbieg, Bing-Yan Zhu, Lisa Marie Barton, Fabio Broccatelli, Georgette Marie Castanedo, Araz Jakalian, Robin Larouche-Gauthier, Arun Yadav
  • AMIDES AS CBL-B INHIBITORS
    Publication number: 20240300927
    Abstract: Various amide compounds that bind Cbl-B, including those that are selective for C-Cbl, and methods of making and using the same.
    Type: Application
    Filed: February 3, 2022
    Publication date: September 12, 2024
    Applicant: Genentech, Inc.
    Inventors: Jun Liang, Araz Jakalian, Michael John Lambrecht, Robin Larouche-Gauthier, Malcolm Huestis, Man Un Ung, Xiaojing Wang, Arun Yadav, Jason Robert Zbieg, Fabio Broccatelli
  • LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL
    Publication number: 20230212153
    Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.
    Type: Application
    Filed: November 4, 2022
    Publication date: July 6, 2023
    Applicant: Genentech, Inc.
    Inventors: Malcolm HUESTIS, Michael John LAMBRECHT, Jun LIANG, Man Un UNG, Xiaojing WANG, Jason Robert ZBIEG, Bing-Yan Zhu, Lisa Marie BARTON, Fabio BROCCATELLI, Georgette Marie CASTANEDO, Araz JAKALIAN, Robin LAROUCHE-GAUTHIER, Arun YADAV
  • LACTAMS AS CBL-B INHIBITORS
    Publication number: 20230079990
    Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same.
    Type: Application
    Filed: February 3, 2022
    Publication date: March 16, 2023
    Applicant: Genentech, Inc.
    Inventors: Jun LIANG, Araz JAKALIAN, Michael John LAMBRECHT, Robin LAROUCHE-GAUTHIER, Malcolm HUESTIS, Man Un UNG, Xiaojing WANG, Arun YADAV, Jason Robert ZBIEG, Fabio BROCCATELLI
  • Respiratory syncytial virus inhibitors
    Patent number: 9708332
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4 and n are defined herein, are useful as inhibitors of RSV.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: July 18, 2017
    Assignee: MEDIVIR AB
    Inventors: Claudio Sturino, Teddy Halmos, Anne Decor, Martin Duplessis, Patrick Deroy, Araz Jakalian, Louis Morency, Cyrille Kuhn, Chantal Grand-Maitre, Martin Tremblay, Christian Brochu
  • RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
    Publication number: 20160272646
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4 and n are defined herein, are useful as inhibitors of RSV.
    Type: Application
    Filed: October 29, 2013
    Publication date: September 22, 2016
    Inventors: Claudio STURINO, Teddy HALMOS, Anne DECOR, Martin DUPLESSIS, Patrick DEROY, Araz JAKALIAN, Louis MORENCY, Cyrille KUHN, Chantal GRAND-MAITRE, Martin TREMBLAY, Christian BROCHU
  • Inhibitors of human immunodeficiency virus replication
    Patent number: 8461180
    Abstract: Compounds of formula (I): wherein c, X, Y, R2, R4 and R5 are defined herein, are useful as inhibitors of HIV replication.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: June 11, 2013
    Assignee: Gilead Sciences, Inc.
    Inventors: Youla S. Tsantrizos, Murray D. Bailey, Punit-Kumar Bhardwaj, Christian Brochu, Paul J. Edwards, Lee Fader, Araz Jakalian, Stephen Kawai, Mathieu Parisien, Marc-Andre Poupart, Bruno Simoneau
  • VIRAL POLYMERASE INHIBITORS
    Publication number: 20120101091
    Abstract: The present application provides compounds of formula I wherein X, Y, R2, n, R5 and R6 are defined herein, useful as inhibitors of the hepatitis C virus NS5B polymerase The present application also provides pharmaceutical compositions containing said compounds, methods of using said compounds as pharmaceuticals alone or with other antiviral agent in the treatment of a hepatitis C viral infection in a mammal having or at risk of having the infection.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 26, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Pierre Beaulieu, Pierre Bonneau, René Coulombe, Pasquale Forgione, James Gillard, Araz Jakalian, Jean Rancourt
  • INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
    Publication number: 20110118249
    Abstract: Compounds of formula (I): wherein c, X, Y, R2, R4 and R5 are defined herein, are useful as inhibitors of HIV replication.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 19, 2011
    Applicant: BOEHRINGER INGLEHEIM INTERNATIONAL GMBH
    Inventors: Youla S. Tsantrizos, Murray D. Bailey, Punit-Kumar Bhardwaj, Christian Brochu, Paul J. Edwards, Lee Fader, Araz Jakalian, Stephen Kawai, Mathieu Parisien, Marc-Andre Poupart, Bruno Simoneau