Patents by Inventor Archita S. AGRAWAL

Archita S. AGRAWAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL KLOTHO INTERACTION SITE IN THE C-TERMINUS OF FGF23
    Publication number: 20230382966
    Abstract: Compositions comprising novel peptides and dimers that exhibit antagonist activity against FGF23 binding to Klotho are disclosed. Such peptides can be used to treat hypoparathyroidism and osteoporosis.
    Type: Application
    Filed: October 26, 2021
    Publication date: November 30, 2023
    Inventors: Richard D. DIMARCHI, Archita S. AGRAWAL
  • FGF21 C-terminal peptide optimization
    Patent number: 11351268
    Abstract: Disclosed herein are modified C-terminal fragments of FGF21 optimized for binding to Klotho ? or antagonizing FGF21 activity. FGF21 peptides modified to comprise modifications to the C-terminal amino acid sequence are disclosed that have enhanced activity at the FGF21 receptor. Additionally, conjugates formed between the optimized FGF21 peptide fragments and insulin like peptides or nuclear hormone receptor ligands are provided.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: June 7, 2022
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Richard D. DiMarchi, Alexei Kharitonenkov, Pengyun Li, Archita S. Agrawal
  • FGF21 C-TERMINAL PEPTIDE OPTIMIZATION
    Publication number: 20200360530
    Abstract: Disclosed herein are modified C-terminal fragments of FGF21 optimized for binding to Klotho ? or antagonizing FGF21 activity. FGF21 peptides modified to comprise modifications to the C-terminal amino acid sequence are disclosed that have enhanced activity at the FGF21 receptor. Additionally, conjugates formed between the optimized FGF21 peptide fragments and insulin like peptides or nuclear hormone receptor ligands are provided.
    Type: Application
    Filed: August 3, 2020
    Publication date: November 19, 2020
    Inventors: Richard D. DiMARCHI, Alexei KHARITONENKOV, Pengyun LI, Archita S. AGRAWAL
  • FGF21 C-TERMINAL PEPTIDE OPTIMIZATION
    Publication number: 20190142963
    Abstract: Disclosed herein are modified C-terminal fragments of FGF21 optimized for binding to Klotho ? or antagonizing FGF21 activity. FGF21 peptides modified to comprise modifications to the C-terminal amino acid sequence are disclosed that have enhanced activity at the FGF21 receptor. Additionally, conjugates formed between the optimized FGF21 peptide fragments and insulin like peptides or nuclear hormone receptor ligands are provided.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 16, 2019
    Inventors: Richard D. DIMARCHI, Alexei KHARITONENKOV, Pengyun LI, Archita S. AGRAWAL