Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: A method of enhancing the quality of a skin scar by topical application of an agent for improving scar quality is characterised in that said agent is pre-emptively applied to a potential surgical cutaneous site in advance of surgery, including surgery involving use of lasers. The topical agent may be a polyphenol, such as (?)-epigallocatechin-3-gallate (EGCG). Use of such a topical agent in advance of surgery leads to significant beneficial effects on dermal scarring by reducing mast cells, angiogenesis, skin thickness and simultaneously increasing elastin content. The topical agent may be applied directly or incorporated in a dressing, such as in a dermal patch comprising an adhesive silicone sheet, and can be worn both in the lead up to surgery and post-operatively.

Abstract: Concentrating devices, systems, and methods include those for separating fluids to be sensed (e.g., analytes, such as volatile organic compounds (VOCs) and/or other chemical substances) from other fluid (e.g., a carrier gas, air, etc.) of a fluid mixture received from a target area of a subject's anatomy (e.g., a subject's skin, a wound on a subject, etc.). In some cases, the concentration system may include a housing and a rotor positioned in a compartment of the housing. The housing may receive a fluid mixture in the compartment and rotation of the rotor relative to the housing may separate fluid to be sensed in the fluid mixture from other fluid of the fluid mixture.

Abstract: Collection devices, systems, and methods include those for collecting volatile organic compounds (VOCs) and/or other chemical substances from a target area of a subject’s anatomy (e.g., a subject’s skin, a wound on a subject, etc.). In some cases, the collector may have a collection component including an adsorbent material. The collector may be used with a pump. The pump may be configured to draw a fluid flow containing one or more chemical substances from a target area on a subject’s anatomy through the collection component. The collection component may be configured to collect at least some of the chemical substances from the fluid flow as the flow passes through the collection component.

Abstract: Detection devices, systems, and methods include those for detecting analytes (e.g., volatile organic compounds (VOCs) and/or other chemical substances) from a target area of a subject's anatomy (e.g., a subject's skin, a wound on a subject, etc.). In some cases, a detector may have a detecting component that includes an analyte sensitive material applied to a substrate. The detector may be used with a pump. The detector may include a hydrophobic, gas permeable material configured to limit liquid reaching the analyte sensitive material, while allowing analytes in gaseous fluid to reach the analyte sensitive material.

Abstract: An implant material having an implant surface comprising a plurality of tissue-contacting members arranged in a regular or irregular two-dimensional array, each tissue-contacting member having a convex curved tissue-contacting surface. Methods of preparing and using such implant materials.

Abstract: An implant material having an implant surface comprising a plurality of tissue-contacting members arranged in a regular or irregular two-dimensional array, each tissue-contacting member having a convex curved tissue-contacting surface. Methods of preparing and using such implant materials.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatihility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: An implant material having an implant surface comprising a plurality of tissue-contacting members arranged in a regular or irregular two-dimensional array, each tissue-contacting member having a convex curved tissue-contacting surface. Methods of preparing and using such implant materials.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: A method of promoting reinnervation of a damaged nerve in a patient comprising electrically stimulating the skin of the patient at a different location from the site of damage to the nerve.

Abstract: The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.

Abstract: A hand-held, surgical instrument to manipulate a patient's tissues having a grip, a first blade, a second blade, a blade actuator, at least one blade rib, a light, and a power source. The first blade and the second blade each extend from the base end of the grip. The second blade is divided longitudinally into a left segment and a right segment, which are each pivotable about a common axis. Movement of the blade actuator causes the segments of the second blade to pivot about the common axis. The light illuminates the patient's tissues proximate the blades. The device may include suction ports on the underside of the first blade to provide aspiration. The blade rib may include multiple longitudinal blade ribs extending along the length of the first blade, the second blade, or both. The blade rib may also include multiple transverse blade ribs extending along the width of the first blade, the second blade, or both.

Abstract: A unique four function surgical instrument that performs aspiration, irrigation, dilation and cauterization with an innovative trigger mechanism. An embodiment is “gun-like” in configuration having a housing with a depending handle and a protruding trigger, a forward extending pair of forceps-like arms that terminate in dilation/cauterization tips and a common conduit between the forceps-like arms. The unique trigger mechanism utilizes a pinch valve concept where the trigger button has an elongated portion that has two slide surfaces with offset a recesses that act like tracks on which pinch sliders follow and the pinch sliders act like valve stems that squeeze close and allow to open silicone tubing. The end result, being a single poll, two stage actuator such that a half a pump of the trigger delivers irrigation or aspiration and a full pump delivers the other.

Abstract: A unique four function surgical instrument that performs aspiration, irrigation, dilation and cauterization with an innovative trigger mechanism. An embodiment is “gun-like” in configuration having a housing with a depending handle and a protruding trigger, a forward extending pair of forceps-like arms that terminate in dilation/cauterization tips and a common conduit between the forceps-like arms. The unique trigger mechanism utilizes a pinch valve concept where the trigger button has an elongated portion that has two slide surfaces with offset a recesses that act like tracks on which pinch sliders follow and the pinch sliders act like valve stems that squeeze close and allow to open silicone tubing. The end result, being a single poll, two stage actuator such that a half a pump of the trigger delivers irrigation or aspiration and a full pump delivers the other.